Motif ID: Hoxa7_Hoxc8

Z-value: 0.654

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8



Activity profile for motif Hoxa7_Hoxc8.

activity profile for motif Hoxa7_Hoxc8


Sorted Z-values histogram for motif Hoxa7_Hoxc8

Sorted Z-values for motif Hoxa7_Hoxc8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Showing 1 to 20 of 85 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710409 8.844 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 8.507 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_62766153 5.971 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 3.767 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 3.437 ENSMUST00000087313.3
 Dcx
doublecortin
chr15_-_37458523 2.143 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr14_-_100149764 2.088 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr8_+_94152607 1.969 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr8_+_45885479 1.962 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr6_-_137169710 1.748 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr19_-_50678642 1.672 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr3_-_66296807 1.655 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1
chr18_-_10706688 1.598 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
 Abhd3


abhydrolase domain containing 3


chr6_+_63255971 1.594 ENSMUST00000159561.1
ENSMUST00000095852.3
 Grid2

glutamate receptor, ionotropic, delta 2

chr4_+_102589687 1.528 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr1_-_127840290 1.497 ENSMUST00000061512.2
 Map3k19
mitogen-activated protein kinase kinase kinase 19
chr10_+_23894688 1.350 ENSMUST00000041416.7
 Vnn1
vanin 1
chr2_+_69897255 1.231 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr1_+_72284367 1.150 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr2_+_83724397 1.097 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
 Itgav


integrin alpha V



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 17.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.4 7.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 2.3 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.6 2.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 2.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.7 2.0 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 1.9 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 1.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 1.6 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.1 1.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.4 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.4 1.1 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.1 1.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.9 GO:0019532 oxalate transport(GO:0019532)
0.0 0.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.7 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.1 0.7 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.7 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.7 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 17.4 GO:0043205 fibril(GO:0043205)
0.0 7.2 GO:0005874 microtubule(GO:0005874)
0.0 2.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.0 GO:0030018 Z disc(GO:0030018)
0.0 1.6 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 1.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)
0.4 1.1 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.1 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.7 GO:0097433 dense body(GO:0097433)
0.1 0.7 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.7 GO:0042581 specific granule(GO:0042581)
0.0 0.7 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.5 GO:0034464 BBSome(GO:0034464)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:0070688 MLL5-L complex(GO:0070688)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 17.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3 7.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 6.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 2.4 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.1 2.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.5 1.6 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 1.6 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 1.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.3 1.4 GO:0034235 GPI anchor binding(GO:0034235)
0.2 1.1 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.7 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.7 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.7 GO:0045296 cadherin binding(GO:0045296)
0.1 0.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)