Motif ID: Hoxa7_Hoxc8

Z-value: 0.654

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8






Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710409 8.844 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 8.507 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_62766153 5.971 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 3.767 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chrX_-_143933089 3.437 ENSMUST00000087313.3
Dcx
doublecortin
chr15_-_37458523 2.143 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr14_-_100149764 2.088 ENSMUST00000097079.4
Klf12
Kruppel-like factor 12
chr8_+_94152607 1.969 ENSMUST00000034211.8
Mt3
metallothionein 3
chr8_+_45885479 1.962 ENSMUST00000034053.5
Pdlim3
PDZ and LIM domain 3
chr6_-_137169710 1.748 ENSMUST00000117919.1
Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr19_-_50678642 1.672 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chr3_-_66296807 1.655 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr18_-_10706688 1.598 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
Abhd3


abhydrolase domain containing 3


chr6_+_63255971 1.594 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr4_+_102589687 1.528 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr1_-_127840290 1.497 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr10_+_23894688 1.350 ENSMUST00000041416.7
Vnn1
vanin 1
chr2_+_69897255 1.231 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr1_+_72284367 1.150 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr2_+_83724397 1.097 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr2_+_69897220 1.002 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr9_-_55919605 0.987 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr10_+_97482350 0.962 ENSMUST00000163448.2
Dcn
decorin
chr4_-_14621805 0.889 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr6_+_145934113 0.868 ENSMUST00000032383.7
Sspn
sarcospan
chr5_+_66968416 0.841 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr10_-_20725023 0.834 ENSMUST00000020165.7
Pde7b
phosphodiesterase 7B
chr5_-_62765618 0.823 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_37518341 0.796 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr3_+_55461758 0.795 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr7_+_35802593 0.756 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr14_+_54431597 0.740 ENSMUST00000089688.4
Mmp14
matrix metallopeptidase 14 (membrane-inserted)
chr11_+_29373618 0.717 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a

coiled coil domain containing 88A

chr14_+_80000292 0.713 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr9_-_103228420 0.711 ENSMUST00000126359.1
Trf
transferrin
chr7_+_51621830 0.687 ENSMUST00000032710.5
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr14_-_36919314 0.647 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr5_+_66968559 0.636 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr2_-_79456750 0.612 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chr4_-_82850721 0.611 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr2_+_116067213 0.605 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr16_-_50330987 0.582 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr15_-_67113909 0.580 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_-_134955908 0.569 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
Ppp1r12b


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr1_-_134955847 0.542 ENSMUST00000168381.1
Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr9_+_113812547 0.533 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr19_-_53944621 0.518 ENSMUST00000135402.2
Bbip1
BBSome interacting protein 1
chr2_-_45117349 0.508 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr17_+_88440711 0.505 ENSMUST00000112238.2
ENSMUST00000155640.1
Foxn2

forkhead box N2

chr18_+_4920509 0.494 ENSMUST00000126977.1
Svil
supervillin
chr2_+_23069210 0.478 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr12_-_87775755 0.476 ENSMUST00000164517.2
Gm21319
predicted gene, 21319
chr13_+_42681513 0.472 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr3_+_121291725 0.445 ENSMUST00000039442.7
Alg14
asparagine-linked glycosylation 14
chr6_-_118479237 0.423 ENSMUST00000161170.1
Zfp9
zinc finger protein 9
chr10_+_115569986 0.413 ENSMUST00000173620.1
A930009A15Rik
RIKEN cDNA A930009A15 gene
chr17_-_29007925 0.410 ENSMUST00000009138.5
ENSMUST00000119274.1
Stk38

serine/threonine kinase 38

chr19_+_5474681 0.388 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr13_+_83732438 0.378 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr1_+_82316452 0.375 ENSMUST00000027322.7
Rhbdd1
rhomboid domain containing 1
chr17_-_45659312 0.373 ENSMUST00000120717.1
Capn11
calpain 11
chr10_-_117148474 0.360 ENSMUST00000020381.3
Frs2
fibroblast growth factor receptor substrate 2
chr18_+_32067729 0.317 ENSMUST00000025243.3
Iws1
IWS1 homolog (S. cerevisiae)
chr10_+_75037066 0.286 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr9_+_110052016 0.250 ENSMUST00000164930.1
ENSMUST00000163979.1
Map4

microtubule-associated protein 4

chr19_-_32196393 0.248 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr4_-_14621494 0.246 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr2_-_116067391 0.245 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr15_+_25773985 0.238 ENSMUST00000125667.1
Myo10
myosin X
chr14_-_108914237 0.217 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1
chr4_+_108719649 0.195 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chrX_+_16619698 0.192 ENSMUST00000026013.5
Maoa
monoamine oxidase A
chr11_+_102285161 0.191 ENSMUST00000156326.1
Tmub2
transmembrane and ubiquitin-like domain containing 2
chr13_+_24801657 0.130 ENSMUST00000019276.4
BC005537
cDNA sequence BC005537
chrM_+_14138 0.128 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chrX_-_101086020 0.114 ENSMUST00000113710.1
Slc7a3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
chr12_-_84617326 0.079 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chrM_-_14060 0.074 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr2_-_177267036 0.073 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr7_+_126950687 0.057 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr7_-_46667375 0.035 ENSMUST00000107669.2
Tph1
tryptophan hydroxylase 1
chr13_+_24802020 0.031 ENSMUST00000155575.1
BC005537
cDNA sequence BC005537
chr1_-_126738167 0.023 ENSMUST00000160693.1
Nckap5
NCK-associated protein 5
chr3_-_59220150 0.019 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr18_-_3281036 0.006 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
Crem


cAMP responsive element modulator



Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 17.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.7 2.0 GO:0097212 lysosomal membrane organization(GO:0097212)
0.6 2.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.4 7.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.4 1.1 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.2 0.5 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.2 0.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 1.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.9 GO:0019532 oxalate transport(GO:0019532)
0.1 0.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 1.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.4 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 0.7 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.1 0.5 GO:0030242 pexophagy(GO:0030242)
0.1 0.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.7 GO:0035988 chondrocyte proliferation(GO:0035988)
0.1 0.3 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 0.3 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 1.6 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.4 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.7 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.7 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.1 GO:0015819 lysine transport(GO:0015819)
0.0 2.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.1 GO:0033762 response to glucagon(GO:0033762)
0.0 0.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 2.3 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 1.9 GO:0031032 actomyosin structure organization(GO:0031032)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 17.4 GO:0043205 fibril(GO:0043205)
0.4 1.1 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.2 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.7 GO:0097433 dense body(GO:0097433)
0.1 0.7 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.7 GO:0042581 specific granule(GO:0042581)
0.0 0.5 GO:0034464 BBSome(GO:0034464)
0.0 0.4 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.7 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.6 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 2.0 GO:0030018 Z disc(GO:0030018)
0.0 2.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 7.2 GO:0005874 microtubule(GO:0005874)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 17.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.5 1.6 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.3 7.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 1.4 GO:0034235 GPI anchor binding(GO:0034235)
0.2 1.1 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.1 6.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.7 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 1.6 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 2.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 2.4 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 0.2 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.7 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.1 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.7 GO:0045296 cadherin binding(GO:0045296)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 1.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.0 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)