Motif ID: Hoxb1

Z-value: 0.612


Transcription factors associated with Hoxb1:

Gene SymbolEntrez IDGene Name
Hoxb1 ENSMUSG00000018973.2 Hoxb1



Activity profile for motif Hoxb1.

activity profile for motif Hoxb1


Sorted Z-values histogram for motif Hoxb1

Sorted Z-values for motif Hoxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_73391160 3.932 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr1_-_119053339 2.217 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr7_-_97417730 1.912 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr19_-_41743665 1.584 ENSMUST00000025993.3
 Slit1
slit homolog 1 (Drosophila)
chr2_+_124610278 1.553 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr3_+_127633134 1.553 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr2_+_124610573 1.544 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chrX_+_166344692 1.342 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chrX_+_110814390 1.188 ENSMUST00000078229.3
 Pou3f4
POU domain, class 3, transcription factor 4
chr1_+_127306706 1.181 ENSMUST00000171405.1
 Mgat5
mannoside acetylglucosaminyltransferase 5
chr3_-_88762244 1.156 ENSMUST00000183267.1
 Syt11
synaptotagmin XI
chr15_+_74516196 1.156 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr1_-_119053619 1.049 ENSMUST00000062483.8
 Gli2
GLI-Kruppel family member GLI2
chr1_+_178798438 0.992 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr7_-_78577771 0.916 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr5_+_19907774 0.815 ENSMUST00000115267.2
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_+_4266323 0.764 ENSMUST00000045730.5
 Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr9_+_50752758 0.678 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr10_+_127677064 0.661 ENSMUST00000118612.1
ENSMUST00000048099.4
 Tmem194

transmembrane protein 194

chr12_+_38780284 0.652 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr1_-_135688094 0.641 ENSMUST00000112103.1
 Nav1
neuron navigator 1
chr1_-_45503282 0.618 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr14_-_69503220 0.603 ENSMUST00000180059.2
 Gm21464
predicted gene, 21464
chr4_+_118428078 0.568 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
 Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr10_+_38965515 0.552 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr8_-_117673682 0.544 ENSMUST00000173522.1
ENSMUST00000174450.1
 Sdr42e1

short chain dehydrogenase/reductase family 42E, member 1

chr18_+_65873478 0.529 ENSMUST00000025395.8
ENSMUST00000173530.1
 Grp

gastrin releasing peptide

chr4_+_103114712 0.519 ENSMUST00000143417.1
 Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr12_-_15816762 0.501 ENSMUST00000020922.7
 Trib2
tribbles homolog 2 (Drosophila)
chr10_-_88605017 0.493 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr18_-_56562187 0.462 ENSMUST00000171844.2
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr5_+_19907502 0.456 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_-_157412576 0.409 ENSMUST00000078308.6
ENSMUST00000139470.1
 Rasal2

RAS protein activator like 2

chr10_-_127666673 0.401 ENSMUST00000026469.2
 Nab2
Ngfi-A binding protein 2
chr18_-_56562215 0.356 ENSMUST00000170309.1
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr4_-_103114555 0.352 ENSMUST00000106868.3
 Wdr78
WD repeat domain 78
chr4_-_103114238 0.348 ENSMUST00000036451.8
ENSMUST00000036557.8
 Wdr78

WD repeat domain 78

chr14_-_69284982 0.280 ENSMUST00000183882.1
ENSMUST00000037064.4
 Slc25a37

solute carrier family 25, member 37

chr10_-_63421739 0.279 ENSMUST00000054760.4
 Gm7075
predicted gene 7075
chr10_-_127666598 0.278 ENSMUST00000099157.3
 Nab2
Ngfi-A binding protein 2
chr4_-_91399984 0.248 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr3_+_41564880 0.226 ENSMUST00000168086.1
 Phf17
PHD finger protein 17
chr9_+_65890237 0.224 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr18_-_56562261 0.184 ENSMUST00000066208.6
ENSMUST00000172734.1
 Aldh7a1

aldehyde dehydrogenase family 7, member A1

chr9_-_91365778 0.176 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr4_+_43669610 0.171 ENSMUST00000107866.1
 Tmem8b
transmembrane protein 8B
chr2_+_119972699 0.157 ENSMUST00000066058.7
 Mapkbp1
mitogen-activated protein kinase binding protein 1
chr10_-_92162753 0.146 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr2_-_91070283 0.136 ENSMUST00000111436.2
ENSMUST00000073575.5
 Slc39a13

solute carrier family 39 (metal ion transporter), member 13

chr11_+_85353156 0.133 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
 Bcas3





breast carcinoma amplified sequence 3





chr6_-_136875794 0.127 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr9_-_13245741 0.125 ENSMUST00000110582.2
 Jrkl
jerky homolog-like (mouse)
chr9_-_91365756 0.122 ENSMUST00000034927.6
 Zic1
zinc finger protein of the cerebellum 1
chr17_+_29490812 0.095 ENSMUST00000024811.6
 Pim1
proviral integration site 1
chr11_-_83298873 0.091 ENSMUST00000175741.1
ENSMUST00000176518.1
 Pex12

peroxisomal biogenesis factor 12

chr4_+_103114385 0.085 ENSMUST00000106858.1
 Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr8_+_25808474 0.072 ENSMUST00000033979.4
 Star
steroidogenic acute regulatory protein
chr3_-_58525867 0.068 ENSMUST00000029385.7
 Serp1
stress-associated endoplasmic reticulum protein 1
chr15_+_89253035 0.063 ENSMUST00000088788.3
 Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr10_+_67185730 0.055 ENSMUST00000173689.1
 Jmjd1c
jumonji domain containing 1C
chr11_+_75486813 0.050 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
 Prpf8


pre-mRNA processing factor 8


chr2_-_91070180 0.043 ENSMUST00000153367.1
ENSMUST00000079976.3
 Slc39a13

solute carrier family 39 (metal ion transporter), member 13

chr10_+_81628540 0.029 ENSMUST00000123896.1
 Ankrd24
ankyrin repeat domain 24
chrX_+_143518671 0.024 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr17_+_34647187 0.016 ENSMUST00000173984.1
 Atf6b
activating transcription factor 6 beta
chr9_-_108083330 0.002 ENSMUST00000159372.1
ENSMUST00000160249.1
 Rnf123

ring finger protein 123


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0060032 notochord regression(GO:0060032)
0.5 0.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.4 3.9 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.4 1.2 GO:1905154 negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154)
0.3 1.0 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 1.6 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 1.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.2 1.3 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.1 0.8 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 1.2 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.1 3.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 0.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.7 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 1.9 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.1 0.6 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.6 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.5 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.7 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 1.6 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.1 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 1.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 3.3 GO:0097542 ciliary tip(GO:0097542)
0.2 0.7 GO:0097512 cardiac myofibril(GO:0097512)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.6 GO:0005605 basal lamina(GO:0005605)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.9 GO:1990459 transferrin receptor binding(GO:1990459)
0.3 1.0 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.2 1.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 1.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.2 0.9 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 1.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 3.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.6 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.5 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0030620 U2 snRNA binding(GO:0030620)