Motif ID: Hoxb2_Dlx2

Z-value: 0.743

Transcription factors associated with Hoxb2_Dlx2:

Gene SymbolEntrez IDGene Name
Dlx2 ENSMUSG00000023391.7 Dlx2
Hoxb2 ENSMUSG00000075588.5 Hoxb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx2mm10_v2_chr2_-_71546745_715467580.431.3e-02Click!


Activity profile for motif Hoxb2_Dlx2.

activity profile for motif Hoxb2_Dlx2


Sorted Z-values histogram for motif Hoxb2_Dlx2

Sorted Z-values for motif Hoxb2_Dlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb2_Dlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 6.977 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr13_-_53473074 4.421 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr3_+_122419772 4.324 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr5_-_62765618 3.718 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_124779686 3.279 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr6_-_23248264 2.930 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_-_62766153 2.866 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_-_102905740 2.853 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr10_-_45470201 2.789 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr2_+_152754156 2.776 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr18_+_23415400 2.732 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr12_+_38780284 2.730 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr15_+_25773985 2.722 ENSMUST00000125667.1
 Myo10
myosin X
chr1_-_190170671 2.703 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr13_-_102906046 2.700 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr4_+_136143497 2.654 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr15_-_37458523 2.531 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr3_+_159839729 2.378 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr3_-_154328634 2.374 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr2_+_109917639 2.282 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 9.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 6.8 GO:0007638 mechanosensory behavior(GO:0007638)
1.4 5.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.5 4.4 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.2 4.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
1.3 4.0 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 4.0 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 3.5 GO:0008360 regulation of cell shape(GO:0008360)
0.2 3.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.8 3.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 3.2 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.4 3.0 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.5 2.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 2.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.8 2.5 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.1 2.5 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.4 2.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 2.4 GO:0031017 exocrine pancreas development(GO:0031017)
0.8 2.3 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 2.2 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.7 4.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 3.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 3.6 GO:0016459 myosin complex(GO:0016459)
0.0 3.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 3.2 GO:0043205 fibril(GO:0043205)
0.3 2.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 2.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.3 GO:0030426 growth cone(GO:0030426)
0.4 2.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 1.8 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.6 GO:0030315 T-tubule(GO:0030315)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.1 1.3 GO:0005915 zonula adherens(GO:0005915)
0.1 1.3 GO:0005581 collagen trimer(GO:0005581)
0.3 1.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 1.0 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 11.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 6.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 6.4 GO:0030165 PDZ domain binding(GO:0030165)
1.1 5.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 4.0 GO:0050693 LBD domain binding(GO:0050693)
0.2 3.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.5 GO:0030507 spectrin binding(GO:0030507)
0.6 3.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 3.2 GO:0000287 magnesium ion binding(GO:0000287)
0.4 3.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 2.7 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 2.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 2.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 2.0 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 1.9 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 1.9 GO:0039706 co-receptor binding(GO:0039706)
0.1 1.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.8 GO:0043522 leucine zipper domain binding(GO:0043522)