Motif ID: Hoxb6

Z-value: 0.312


Transcription factors associated with Hoxb6:

Gene SymbolEntrez IDGene Name
Hoxb6 ENSMUSG00000000690.4 Hoxb6



Activity profile for motif Hoxb6.

activity profile for motif Hoxb6


Sorted Z-values histogram for motif Hoxb6

Sorted Z-values for motif Hoxb6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_119238794 1.332 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr10_-_58675631 1.331 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chrX_-_143933204 1.014 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr8_+_13435459 0.919 ENSMUST00000167071.1
ENSMUST00000167505.1
 Tmem255b

transmembrane protein 255B

chr10_-_64090265 0.912 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr1_-_22805994 0.750 ENSMUST00000097808.4
 Rims1
regulating synaptic membrane exocytosis 1
chr19_-_40402267 0.733 ENSMUST00000099467.3
ENSMUST00000099466.3
ENSMUST00000165212.1
ENSMUST00000165469.1
 Sorbs1



sorbin and SH3 domain containing 1



chr13_-_85127514 0.667 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr7_+_113207465 0.600 ENSMUST00000047321.7
 Arntl
aryl hydrocarbon receptor nuclear translocator-like
chrX_-_143933089 0.576 ENSMUST00000087313.3
 Dcx
doublecortin
chr3_-_94412883 0.534 ENSMUST00000181305.1
 1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr4_-_138326234 0.499 ENSMUST00000105817.3
ENSMUST00000030536.6
 Pink1

PTEN induced putative kinase 1

chr3_-_116712644 0.483 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr3_+_68572245 0.456 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr9_-_70141484 0.442 ENSMUST00000034749.8
 Fam81a
family with sequence similarity 81, member A
chr19_+_25406661 0.392 ENSMUST00000146647.1
 Kank1
KN motif and ankyrin repeat domains 1
chr8_-_77610597 0.387 ENSMUST00000034030.8
 Tmem184c
transmembrane protein 184C
chr8_-_77610668 0.382 ENSMUST00000141202.1
ENSMUST00000152168.1
 Tmem184c

transmembrane protein 184C

chr19_-_6925367 0.370 ENSMUST00000057716.4
 Tex40
testis expressed 40
chr11_-_69795930 0.364 ENSMUST00000045971.8
 Chrnb1
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
chr8_-_105471481 0.330 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr3_+_94413244 0.245 ENSMUST00000166032.1
ENSMUST00000045245.5
 Tdrkh

tudor and KH domain containing protein

chr9_+_92309362 0.233 ENSMUST00000098477.1
ENSMUST00000150594.1
 1700057G04Rik

RIKEN cDNA 1700057G04 gene

chr13_+_58281183 0.211 ENSMUST00000180882.1
ENSMUST00000180452.1
 Gm26555

predicted gene, 26555

chr3_+_66985680 0.211 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr19_+_26748268 0.207 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
 Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chr5_+_88583527 0.196 ENSMUST00000031229.6
 Rufy3
RUN and FYVE domain containing 3
chr6_+_49319274 0.179 ENSMUST00000055559.7
ENSMUST00000114491.1
 Ccdc126

coiled-coil domain containing 126

chr11_-_74724670 0.176 ENSMUST00000021091.8
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr2_-_125859139 0.167 ENSMUST00000110463.1
ENSMUST00000028635.5
 Cops2

COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)

chr15_-_43869993 0.121 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr13_-_21810190 0.099 ENSMUST00000110469.1
ENSMUST00000091749.2
 Hist1h2bq

histone cluster 1, H2bq

chr3_+_66985647 0.098 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr1_-_36273425 0.092 ENSMUST00000056946.6
 Neurl3
neuralized homolog 3 homolog (Drosophila)
chr11_-_72215592 0.084 ENSMUST00000021157.8
 Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr14_+_118137101 0.058 ENSMUST00000022728.2
 Gpr180
G protein-coupled receptor 180
chr2_+_164769892 0.030 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr8_-_54724474 0.022 ENSMUST00000175915.1
 Wdr17
WD repeat domain 17
chr13_+_93304066 0.019 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr3_-_119783262 0.004 ENSMUST00000029780.7
 Ptbp2
polypyrimidine tract binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.2 0.8 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.2 0.5 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.1 1.3 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 0.4 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.5 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 1.6 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.9 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0 1.3 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.4 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.2 GO:0051661 maintenance of centrosome location(GO:0051661) regulation of microtubule motor activity(GO:2000574)
0.0 0.7 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 0.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.5 GO:0001553 luteinization(GO:0001553)
0.0 0.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.6 GO:0033391 chromatoid body(GO:0033391)
0.1 1.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 2.1 GO:0010857 calcium-dependent protein kinase activity(GO:0010857)
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.4 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.2 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.5 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)