Motif ID: Hoxb7

Z-value: 4.221


Transcription factors associated with Hoxb7:

Gene SymbolEntrez IDGene Name
Hoxb7 ENSMUSG00000038721.8 Hoxb7



Activity profile for motif Hoxb7.

activity profile for motif Hoxb7


Sorted Z-values histogram for motif Hoxb7

Sorted Z-values for motif Hoxb7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_55681257 54.532 ENSMUST00000044767.8
 Neurod6
neurogenic differentiation 6
chr1_+_19103022 43.365 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr13_+_83504032 40.044 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr8_-_84773381 38.937 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr8_+_54954728 38.837 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr1_+_177445660 37.837 ENSMUST00000077225.6
 Zbtb18
zinc finger and BTB domain containing 18
chr3_+_18054258 37.733 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr16_+_7069825 36.398 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr12_+_29528382 32.359 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr11_+_77930800 32.168 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr17_+_3397189 31.389 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr5_+_117841839 30.395 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr2_+_61804453 29.736 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr3_+_55461758 29.341 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr1_+_177444653 28.670 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr2_+_71528657 28.478 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr1_-_56969827 28.002 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr19_+_26605106 27.865 ENSMUST00000025862.7
ENSMUST00000176030.1
 Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr4_+_13751297 27.626 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_-_56969864 27.212 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 389 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 144.3 GO:0006376 mRNA splice site selection(GO:0006376)
3.3 110.2 GO:0060074 synapse maturation(GO:0060074)
6.5 103.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
7.4 66.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
5.5 60.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.7 59.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.8 57.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.7 53.5 GO:0001578 microtubule bundle formation(GO:0001578)
8.7 52.0 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
10.0 49.8 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
1.4 49.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
5.4 48.4 GO:0071420 cellular response to histamine(GO:0071420)
3.2 48.3 GO:0021860 pyramidal neuron development(GO:0021860)
16.0 48.1 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.8 47.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
2.8 47.0 GO:0086018 SA node cell action potential(GO:0086015) SA node cell to atrial cardiac muscle cell signalling(GO:0086018) SA node cell to atrial cardiac muscle cell communication(GO:0086070)
5.8 46.7 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
3.5 45.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
7.1 42.5 GO:0072318 clathrin coat disassembly(GO:0072318)
0.5 41.9 GO:0031532 actin cytoskeleton reorganization(GO:0031532)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 161.1 GO:0060076 excitatory synapse(GO:0060076)
0.7 157.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 82.1 GO:0005768 endosome(GO:0005768)
0.8 80.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 68.9 GO:0016021 integral component of membrane(GO:0016021)
1.3 67.9 GO:0045171 intercellular bridge(GO:0045171)
3.5 66.8 GO:0071564 npBAF complex(GO:0071564)
1.5 62.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
3.9 62.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
2.9 58.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 58.5 GO:0045202 synapse(GO:0045202)
1.7 54.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
5.7 51.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
2.4 50.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
2.7 49.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
3.2 48.0 GO:0031045 dense core granule(GO:0031045)
0.2 42.5 GO:0016604 nuclear body(GO:0016604)
1.1 38.7 GO:0042734 presynaptic membrane(GO:0042734)
0.3 38.3 GO:0016607 nuclear speck(GO:0016607)
3.4 37.6 GO:0043083 synaptic cleft(GO:0043083)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 238 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 88.1 GO:0005057 receptor signaling protein activity(GO:0005057)
2.9 85.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.5 80.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 78.8 GO:0044822 poly(A) RNA binding(GO:0044822)
0.7 75.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
3.0 69.7 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
2.0 58.4 GO:0001786 phosphatidylserine binding(GO:0001786)
3.4 57.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
6.9 55.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.7 51.3 GO:0070412 R-SMAD binding(GO:0070412)
0.2 50.3 GO:0008017 microtubule binding(GO:0008017)
2.7 49.1 GO:0004890 GABA-A receptor activity(GO:0004890)
1.0 48.0 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
1.9 45.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.7 45.5 GO:0005262 calcium channel activity(GO:0005262)
0.4 44.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
7.2 43.5 GO:0070699 type II activin receptor binding(GO:0070699)
3.9 43.2 GO:0038191 neuropilin binding(GO:0038191)
1.4 40.4 GO:0017091 AU-rich element binding(GO:0017091)
9.6 38.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)