Motif ID: Hoxb8_Pdx1

Z-value: 0.816

Transcription factors associated with Hoxb8_Pdx1:

Gene SymbolEntrez IDGene Name
Hoxb8 ENSMUSG00000056648.4 Hoxb8
Pdx1 ENSMUSG00000029644.6 Pdx1



Activity profile for motif Hoxb8_Pdx1.

activity profile for motif Hoxb8_Pdx1


Sorted Z-values histogram for motif Hoxb8_Pdx1

Sorted Z-values for motif Hoxb8_Pdx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb8_Pdx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_143933204 4.246 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr19_+_4711153 3.715 ENSMUST00000008991.6
 Sptbn2
spectrin beta, non-erythrocytic 2
chr16_-_23890805 3.592 ENSMUST00000004480.3
 Sst
somatostatin
chr15_+_21111452 2.888 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr1_-_126830632 2.757 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chrX_-_143933089 2.710 ENSMUST00000087313.3
 Dcx
doublecortin
chr1_-_56972437 2.442 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr9_+_40269202 2.339 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr9_+_40269273 2.289 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr7_+_44384098 2.188 ENSMUST00000118962.1
ENSMUST00000118831.1
 Syt3

synaptotagmin III

chr17_+_39846958 2.141 ENSMUST00000182010.1
 Gm26924
predicted gene, 26924
chr4_+_33924632 1.957 ENSMUST00000057188.6
 Cnr1
cannabinoid receptor 1 (brain)
chr8_+_83666827 1.950 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr8_+_34807287 1.924 ENSMUST00000033930.4
 Dusp4
dual specificity phosphatase 4
chr1_-_56969864 1.724 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_176807124 1.706 ENSMUST00000057037.7
 Cep170
centrosomal protein 170
chr1_-_33907721 1.685 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr9_+_99243421 1.584 ENSMUST00000093795.3
 Cep70
centrosomal protein 70
chr1_-_56971762 1.486 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chrX_+_134295225 1.458 ENSMUST00000037687.7
 Tmem35
transmembrane protein 35

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.0 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 4.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 4.6 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 3.7 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 2.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 2.6 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 2.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.8 2.5 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 2.5 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 2.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 2.1 GO:0030279 negative regulation of ossification(GO:0030279)
0.5 2.0 GO:0031622 positive regulation of fever generation(GO:0031622)
0.2 2.0 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.4 1.7 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.5 GO:0006491 N-glycan processing(GO:0006491)
0.2 1.4 GO:0032790 ribosome disassembly(GO:0032790)
0.2 1.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 1.2 GO:0060346 bone trabecula formation(GO:0060346)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.7 GO:0030425 dendrite(GO:0030425)
0.3 4.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.6 3.7 GO:0008091 spectrin(GO:0008091)
0.0 2.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 2.5 GO:0044295 axonal growth cone(GO:0044295)
0.2 2.4 GO:0045298 tubulin complex(GO:0045298)
0.0 2.2 GO:0070382 exocytic vesicle(GO:0070382)
0.1 2.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.0 GO:0030426 growth cone(GO:0030426)
0.1 1.9 GO:0043034 costamere(GO:0043034)
0.0 1.8 GO:0043679 axon terminus(GO:0043679)
0.1 1.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.7 GO:0005814 centriole(GO:0005814)
0.0 1.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.1 GO:0005869 dynactin complex(GO:0005869)
0.3 0.8 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.7 4.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 3.6 GO:0005179 hormone activity(GO:0005179)
0.1 2.8 GO:0071813 lipoprotein particle binding(GO:0071813) protein-lipid complex binding(GO:0071814)
0.1 2.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.9 2.6 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 2.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.5 2.0 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.3 2.0 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 2.0 GO:0008144 drug binding(GO:0008144)
0.1 1.9 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.4 1.8 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.6 1.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 1.4 GO:0008201 heparin binding(GO:0008201)
0.4 1.3 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.2 GO:0005496 steroid binding(GO:0005496)