Motif ID: Hoxd11_Cdx1_Hoxc11

Z-value: 0.708

Transcription factors associated with Hoxd11_Cdx1_Hoxc11:

Gene SymbolEntrez IDGene Name
Cdx1 ENSMUSG00000024619.8 Cdx1
Hoxc11 ENSMUSG00000001656.3 Hoxc11
Hoxd11 ENSMUSG00000042499.12 Hoxd11



Activity profile for motif Hoxd11_Cdx1_Hoxc11.

activity profile for motif Hoxd11_Cdx1_Hoxc11


Sorted Z-values histogram for motif Hoxd11_Cdx1_Hoxc11

Sorted Z-values for motif Hoxd11_Cdx1_Hoxc11



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_84064772 6.606 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr1_+_159737510 6.495 ENSMUST00000111669.3
 Tnr
tenascin R
chr17_-_91092715 6.316 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr5_-_62766153 5.885 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_144893127 4.909 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr15_+_81936753 4.852 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr15_+_81936911 4.785 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr4_+_144892813 3.182 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr5_-_62765618 2.999 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_-_64046925 2.945 ENSMUST00000107377.3
 Tnc
tenascin C
chr3_+_62419668 2.941 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr8_+_57455898 2.777 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr13_-_101692624 2.683 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr17_+_3397189 2.559 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr4_+_144893077 2.377 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_76074270 2.324 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr8_-_105943382 2.229 ENSMUST00000038896.7
 Lcat
lecithin cholesterol acyltransferase
chr18_+_69593361 2.224 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr11_-_79504078 1.992 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr4_+_136143497 1.798 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 10.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 8.7 GO:0006397 mRNA processing(GO:0006397)
1.4 7.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
2.2 6.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.7 2.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 2.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.3 2.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.4 2.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.2 2.2 GO:0042118 endothelial cell activation(GO:0042118)
0.1 2.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.3 2.1 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.1 2.0 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 1.8 GO:0071398 cellular response to fatty acid(GO:0071398)
0.0 1.8 GO:0045814 negative regulation of gene expression, epigenetic(GO:0045814)
0.3 1.4 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.2 1.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 1.4 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.1 1.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 1.4 GO:0046677 response to antibiotic(GO:0046677)
0.0 1.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.1 GO:0042734 presynaptic membrane(GO:0042734)
2.2 6.5 GO:0072534 perineuronal net(GO:0072534)
0.1 3.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 2.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.8 GO:0016607 nuclear speck(GO:0016607)
0.1 2.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.7 GO:0000786 nucleosome(GO:0000786)
0.1 2.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.2 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.7 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.6 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.6 GO:0051233 spindle midzone(GO:0051233)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 10.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 8.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.6 7.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.4 6.5 GO:0046625 sphingolipid binding(GO:0046625)
0.0 4.5 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 4.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 2.9 GO:0045545 syndecan binding(GO:0045545)
0.7 2.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.6 2.2 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.6 2.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 2.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 1.8 GO:0005504 fatty acid binding(GO:0005504)
0.3 1.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 1.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.1 GO:0032183 SUMO binding(GO:0032183)
0.1 1.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.0 GO:0031690 adrenergic receptor binding(GO:0031690)