Motif ID: Hoxd12

Z-value: 0.688


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710409 4.558 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_-_84064772 4.535 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr1_+_159737510 4.235 ENSMUST00000111669.3
Tnr
tenascin R
chr15_-_8710734 4.035 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_62766153 3.448 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_144893127 3.283 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 3.080 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr16_+_42907563 2.661 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr15_+_81936911 2.408 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr4_+_144893077 2.337 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr15_+_81936753 2.157 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr1_-_56969864 2.082 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr3_+_9403049 2.041 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
C030034L19Rik


RIKEN cDNA C030034L19 gene


chr17_-_91092715 1.988 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr1_-_56969827 1.948 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr5_-_62765618 1.878 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_+_3397189 1.744 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr13_-_101692624 1.727 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr18_-_35215008 1.662 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr1_-_69108039 1.485 ENSMUST00000121473.1
Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr3_+_122419772 1.462 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr11_+_29463735 1.407 ENSMUST00000155854.1
Ccdc88a
coiled coil domain containing 88A
chr1_+_19103022 1.394 ENSMUST00000037294.7
Tfap2d
transcription factor AP-2, delta
chr2_+_73271925 1.366 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr3_+_76074270 1.357 ENSMUST00000038364.8
Fstl5
follistatin-like 5
chrX_-_143933089 1.279 ENSMUST00000087313.3
Dcx
doublecortin
chr1_-_165934900 1.245 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr5_+_107497762 1.231 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr11_-_109472611 1.199 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr3_-_126998408 1.197 ENSMUST00000182764.1
ENSMUST00000044443.8
Ank2

ankyrin 2, brain

chr14_-_36919513 1.173 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr4_-_82505707 1.114 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib

nuclear factor I/B

chr14_-_36919314 1.083 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr5_+_107497718 0.955 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr9_-_13245741 0.886 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr4_-_82505749 0.860 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib

nuclear factor I/B

chr5_-_73256555 0.840 ENSMUST00000101127.5
ENSMUST00000171179.1
Fryl
Fryl
furry homolog-like (Drosophila)
furry homolog-like (Drosophila)
chr4_-_82850721 0.839 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr4_-_154636831 0.836 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chrX_-_143933204 0.825 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr3_+_66985680 0.801 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr11_-_109473220 0.792 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr19_-_45812291 0.760 ENSMUST00000086993.4
Kcnip2
Kv channel-interacting protein 2
chr4_+_31964081 0.725 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
Map3k7



mitogen-activated protein kinase kinase kinase 7



chr3_+_108591279 0.723 ENSMUST00000051145.8
ENSMUST00000139626.1
Wdr47

WD repeat domain 47

chr5_+_19907502 0.721 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_-_30655859 0.657 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr5_-_24030649 0.645 ENSMUST00000030849.6
Fam126a
family with sequence similarity 126, member A
chr4_-_88033328 0.632 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr12_+_55836365 0.621 ENSMUST00000059250.6
Brms1l
breast cancer metastasis-suppressor 1-like
chr2_+_116900152 0.613 ENSMUST00000126467.1
ENSMUST00000128305.1
ENSMUST00000155323.1
D330050G23Rik


RIKEN cDNA D330050G23 gene


chr14_+_66868850 0.610 ENSMUST00000100453.1
Gm5464
predicted gene 5464
chr16_-_50432340 0.608 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
Bbx




bobby sox homolog (Drosophila)




chr13_+_80883403 0.600 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr13_-_97747399 0.598 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_-_141931523 0.593 ENSMUST00000106232.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr2_-_45117349 0.565 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr15_+_25773985 0.553 ENSMUST00000125667.1
Myo10
myosin X
chr16_+_11405648 0.550 ENSMUST00000096273.2
Snx29
sorting nexin 29
chr1_-_152625212 0.513 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr2_-_180824596 0.441 ENSMUST00000148700.1
Gm14340
predicted gene 14340
chr4_+_136284658 0.420 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr9_-_77347816 0.412 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr4_+_136284708 0.400 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr5_-_74531619 0.393 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2



Sec1 family domain containing 2



chr5_-_5265224 0.375 ENSMUST00000115450.1
Cdk14
cyclin-dependent kinase 14
chrX_-_75578188 0.367 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr19_+_60755947 0.342 ENSMUST00000088237.4
Nanos1
nanos homolog 1 (Drosophila)
chr18_-_3281712 0.338 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
Crem



cAMP responsive element modulator



chr10_+_69787431 0.332 ENSMUST00000183240.1
Ank3
ankyrin 3, epithelial
chr3_+_66985647 0.321 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr2_+_71786923 0.314 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6

integrin alpha 6

chr4_-_11981265 0.306 ENSMUST00000098260.2
Gm10604
predicted gene 10604
chr2_-_66410064 0.294 ENSMUST00000112366.1
Scn1a
sodium channel, voltage-gated, type I, alpha
chr10_+_90071095 0.282 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_+_65930117 0.268 ENSMUST00000176109.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr16_-_89508313 0.266 ENSMUST00000056118.2
Krtap7-1
keratin associated protein 7-1
chr3_+_66985947 0.261 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr18_-_37020679 0.258 ENSMUST00000097612.2
Gm10545
predicted gene 10545
chr1_+_81077274 0.255 ENSMUST00000068275.5
ENSMUST00000113494.2
Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr1_-_175688353 0.251 ENSMUST00000104984.1
Chml
choroideremia-like
chr8_-_47352348 0.244 ENSMUST00000110367.2
Stox2
storkhead box 2
chr2_-_114013619 0.240 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr3_+_41024369 0.239 ENSMUST00000099121.3
Larp1b
La ribonucleoprotein domain family, member 1B
chr6_+_125215551 0.232 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
Vamp1


vesicle-associated membrane protein 1


chr19_-_6987621 0.214 ENSMUST00000130048.1
ENSMUST00000025914.6
Vegfb

vascular endothelial growth factor B

chr3_+_103575231 0.212 ENSMUST00000121834.1
Syt6
synaptotagmin VI
chr3_+_103575275 0.195 ENSMUST00000090697.4
Syt6
synaptotagmin VI
chr1_+_153874335 0.175 ENSMUST00000055314.3
Gm5531
predicted gene 5531
chr16_-_35769356 0.166 ENSMUST00000023554.8
Dirc2
disrupted in renal carcinoma 2 (human)
chr10_+_26822560 0.156 ENSMUST00000135866.1
Arhgap18
Rho GTPase activating protein 18
chr5_-_24842579 0.155 ENSMUST00000030787.8
Rheb
Ras homolog enriched in brain
chr13_-_97747373 0.154 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr9_-_77347787 0.136 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr10_-_13324160 0.105 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chrX_+_106920618 0.098 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr3_+_66985700 0.088 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr11_-_118355496 0.087 ENSMUST00000017610.3
Timp2
tissue inhibitor of metalloproteinase 2
chr7_+_4922251 0.087 ENSMUST00000047309.5
Nat14
N-acetyltransferase 14
chr4_+_148000722 0.085 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr1_+_81077204 0.073 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr2_-_36104060 0.068 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr17_-_35897073 0.065 ENSMUST00000150056.1
ENSMUST00000156817.1
ENSMUST00000146451.1
ENSMUST00000148482.1
2310061I04Rik



RIKEN cDNA 2310061I04 gene



chr14_+_32085804 0.055 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
Oxnad1


oxidoreductase NAD-binding domain containing 1


chr10_+_116177351 0.037 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chr8_+_69902178 0.034 ENSMUST00000050373.5
Tssk6
testis-specific serine kinase 6
chr16_+_65520503 0.030 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
Pou1f1


POU domain, class 1, transcription factor 1


chr1_+_59256906 0.026 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15

cyclin-dependent kinase 15

chr4_-_133968611 0.013 ENSMUST00000102552.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr7_-_37772868 0.002 ENSMUST00000176205.1
Zfp536
zinc finger protein 536

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.4 4.2 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.8 8.7 GO:0042572 retinol metabolic process(GO:0042572)
0.5 2.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 2.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3 1.5 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.2 3.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 0.6 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.2 0.7 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 1.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 0.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.7 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.1 0.4 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 1.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 2.1 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 2.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.6 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.8 GO:0090527 actin filament reorganization(GO:0090527)
0.1 2.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.2 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 0.2 GO:0061043 regulation of vascular wound healing(GO:0061043)
0.1 1.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 0.6 GO:0007379 segment specification(GO:0007379)
0.1 1.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 1.4 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 1.5 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 2.3 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.2 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.3 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.2 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.3 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 1.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0072534 perineuronal net(GO:0072534)
0.5 8.6 GO:0043205 fibril(GO:0043205)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 2.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 1.2 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0070820 tertiary granule(GO:0070820)
0.0 4.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 2.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.6 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
1.2 8.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 1.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.4 1.8 GO:0038132 neuregulin binding(GO:0038132)
0.3 4.2 GO:0046625 sphingolipid binding(GO:0046625)
0.2 0.7 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.2 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 2.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 2.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 5.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.4 GO:0043422 protein kinase B binding(GO:0043422)
0.1 1.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.6 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.6 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.3 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)