Motif ID: Hoxd8

Z-value: 0.524


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Showing 1 to 20 of 74 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_80165013 2.807 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6

myosin VI

chr1_+_9547948 2.519 ENSMUST00000144177.1
Adhfe1
alcohol dehydrogenase, iron containing, 1
chr3_+_76075583 2.215 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr10_+_97482350 1.728 ENSMUST00000163448.2
Dcn
decorin
chr9_+_80165079 1.715 ENSMUST00000184480.1
Myo6
myosin VI
chr2_+_83724397 1.680 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr13_-_85127514 1.281 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr5_-_62766153 1.241 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_+_49608030 1.147 ENSMUST00000021822.5
Ogn
osteoglycin
chr1_-_127840290 1.099 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr3_+_127633134 1.081 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr1_+_178798438 1.066 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr3_-_116712644 1.046 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr7_+_110772604 0.976 ENSMUST00000005829.6
Ampd3
adenosine monophosphate deaminase 3
chr10_-_25200110 0.974 ENSMUST00000100012.2
Akap7
A kinase (PRKA) anchor protein 7
chr17_+_74489492 0.863 ENSMUST00000024873.6
Yipf4
Yip1 domain family, member 4
chr8_+_40354303 0.791 ENSMUST00000136835.1
Micu3
mitochondrial calcium uptake family, member 3
chr12_-_84617326 0.788 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr3_-_96197580 0.632 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chr15_-_35155750 0.627 ENSMUST00000067033.7
ENSMUST00000018476.7
Stk3

serine/threonine kinase 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.5 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 2.6 GO:0006818 hydrogen transport(GO:0006818)
0.6 1.7 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.2 1.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.4 1.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 1.0 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 1.0 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 1.0 GO:0032264 IMP salvage(GO:0032264)
0.1 0.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 0.6 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.6 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 0.5 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
0.1 0.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 0.4 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.4 GO:0046415 urate metabolic process(GO:0046415)
0.1 0.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 0.3 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.2 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.6 1.7 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.1 1.7 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.2 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0003774 motor activity(GO:0003774)
0.0 2.5 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.3 1.7 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.0 1.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.7 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.1 GO:0070888 E-box binding(GO:0070888)
0.0 1.1 GO:0008083 growth factor activity(GO:0008083)
0.1 1.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.0 GO:0016208 AMP binding(GO:0016208)
0.0 1.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.2 0.6 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.6 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 0.5 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.4 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.4 GO:0052650 retinal binding(GO:0016918) NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.3 GO:0048406 nerve growth factor binding(GO:0048406)