Motif ID: Hoxd9

Z-value: 0.734


Transcription factors associated with Hoxd9:

Gene SymbolEntrez IDGene Name
Hoxd9 ENSMUSG00000043342.8 Hoxd9



Activity profile for motif Hoxd9.

activity profile for motif Hoxd9


Sorted Z-values histogram for motif Hoxd9

Sorted Z-values for motif Hoxd9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_78206408 4.350 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr6_-_36811361 3.433 ENSMUST00000101534.1
Ptn
pleiotrophin
chr15_-_37459327 3.356 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chrX_+_82948861 3.242 ENSMUST00000114000.1
Dmd
dystrophin, muscular dystrophy
chr5_-_62766153 3.163 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_-_105271039 3.161 ENSMUST00000069686.6
Rnf180
ring finger protein 180
chr12_+_38783503 3.035 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr13_-_41273977 2.943 ENSMUST00000163881.1
Gm17364
predicted gene, 17364
chr3_-_116129615 2.835 ENSMUST00000029574.8
Vcam1
vascular cell adhesion molecule 1
chr4_+_136143497 2.754 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr11_+_29373618 2.722 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a

coiled coil domain containing 88A

chr11_-_109472611 2.608 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr2_-_84425258 2.537 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chr19_+_23723279 2.311 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr2_-_63184253 2.245 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr3_-_66296807 2.087 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr5_-_77408034 1.950 ENSMUST00000163898.1
ENSMUST00000046746.6
Igfbp7

insulin-like growth factor binding protein 7

chr1_+_167598450 1.950 ENSMUST00000111386.1
ENSMUST00000111384.1
Rxrg

retinoid X receptor gamma

chr11_+_110968016 1.929 ENSMUST00000106636.1
ENSMUST00000180023.1
Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr1_-_175491130 1.912 ENSMUST00000027812.5
Rgs7
regulator of G protein signaling 7
chrX_+_85048309 1.784 ENSMUST00000113991.1
ENSMUST00000113992.2
Dmd

dystrophin, muscular dystrophy

chr5_-_62765618 1.770 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_84723003 1.716 ENSMUST00000098571.4
G430095P16Rik
RIKEN cDNA G430095P16 gene
chr5_+_63812447 1.703 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr14_-_100149764 1.663 ENSMUST00000097079.4
Klf12
Kruppel-like factor 12
chr15_-_65014904 1.533 ENSMUST00000110100.2
Gm21961
predicted gene, 21961
chr14_-_36919314 1.389 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr6_+_145934113 1.299 ENSMUST00000032383.7
Sspn
sarcospan
chr7_+_127800604 1.288 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr2_+_67748212 1.177 ENSMUST00000180887.1
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr3_+_35754121 1.172 ENSMUST00000108186.1
ENSMUST00000029257.8
Atp11b

ATPase, class VI, type 11B

chr19_-_29753600 1.157 ENSMUST00000175764.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr2_-_63184170 1.107 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr7_+_66365905 1.093 ENSMUST00000107486.1
Gm10974
predicted gene 10974
chr1_+_167598384 1.092 ENSMUST00000015987.3
Rxrg
retinoid X receptor gamma
chr5_-_69590783 1.062 ENSMUST00000173927.1
Gnpda2
glucosamine-6-phosphate deaminase 2
chr2_-_175131864 1.051 ENSMUST00000108929.2
Gm14399
predicted gene 14399
chr8_+_66386292 0.994 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr13_-_74376566 0.986 ENSMUST00000091481.2
Zfp72
zinc finger protein 72
chr6_+_48537560 0.960 ENSMUST00000040361.5
Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr8_+_71887264 0.941 ENSMUST00000034259.7
Zfp709
zinc finger protein 709
chr10_+_115569986 0.928 ENSMUST00000173620.1
A930009A15Rik
RIKEN cDNA A930009A15 gene
chr14_-_118923070 0.911 ENSMUST00000047208.5
Dzip1
DAZ interacting protein 1
chr10_+_75037066 0.910 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chrM_+_11734 0.898 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr3_-_88772578 0.870 ENSMUST00000090945.4
Syt11
synaptotagmin XI
chr9_-_39604124 0.865 ENSMUST00000042485.4
ENSMUST00000141370.1
AW551984

expressed sequence AW551984

chr7_+_120851183 0.843 ENSMUST00000106487.1
ENSMUST00000143322.1
ENSMUST00000106488.1
Eef2k


eukaryotic elongation factor-2 kinase


chr12_+_102128718 0.832 ENSMUST00000159329.1
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr7_-_103827922 0.752 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr7_-_16286744 0.749 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
Ccdc9


coiled-coil domain containing 9


chr7_-_34313531 0.738 ENSMUST00000108074.1
4931406P16Rik
RIKEN cDNA 4931406P16 gene
chr17_-_78684262 0.728 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr2_+_91526756 0.716 ENSMUST00000111338.3
Ckap5
cytoskeleton associated protein 5
chr9_-_21989427 0.675 ENSMUST00000045726.6
Rgl3
ral guanine nucleotide dissociation stimulator-like 3
chr14_-_75754475 0.663 ENSMUST00000049168.7
Cog3
component of oligomeric golgi complex 3
chr1_+_180111339 0.644 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr19_+_46689902 0.643 ENSMUST00000074912.7
2010012O05Rik
RIKEN cDNA 2010012O05 gene
chr2_-_45117349 0.638 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr3_+_53845086 0.638 ENSMUST00000108014.1
Gm10985
predicted gene 10985
chr17_-_45474839 0.593 ENSMUST00000024731.8
Spats1
spermatogenesis associated, serine-rich 1
chrX_-_49797700 0.561 ENSMUST00000033442.7
ENSMUST00000114891.1
Igsf1

immunoglobulin superfamily, member 1

chr19_+_56548254 0.551 ENSMUST00000071423.5
Nhlrc2
NHL repeat containing 2
chr2_+_11172080 0.534 ENSMUST00000114853.1
Prkcq
protein kinase C, theta
chr16_-_50330987 0.507 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr3_+_114030532 0.481 ENSMUST00000123619.1
ENSMUST00000092155.5
Col11a1

collagen, type XI, alpha 1

chr1_+_183388981 0.478 ENSMUST00000097043.5
Taf1a
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
chr19_-_56548122 0.476 ENSMUST00000026063.5
ENSMUST00000182276.1
Dclre1a

DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)

chr10_-_63421739 0.467 ENSMUST00000054760.4
Gm7075
predicted gene 7075
chr2_-_116064721 0.460 ENSMUST00000110906.2
Meis2
Meis homeobox 2
chr18_+_32067729 0.451 ENSMUST00000025243.3
Iws1
IWS1 homolog (S. cerevisiae)
chr19_-_56548013 0.440 ENSMUST00000182059.1
Dclre1a
DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)
chr3_+_32436376 0.434 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr18_+_37355271 0.431 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr7_+_30565410 0.399 ENSMUST00000043850.7
Igflr1
IGF-like family receptor 1
chr7_-_29906524 0.378 ENSMUST00000159920.1
ENSMUST00000162592.1
Zfp27

zinc finger protein 27

chr16_-_65562686 0.370 ENSMUST00000004965.6
Chmp2b
charged multivesicular body protein 2B
chr1_+_180330470 0.357 ENSMUST00000070181.6
Itpkb
inositol 1,4,5-trisphosphate 3-kinase B
chr12_+_77238093 0.345 ENSMUST00000177595.1
ENSMUST00000171770.2
Fut8

fucosyltransferase 8

chr18_+_37400845 0.337 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr16_+_20696175 0.307 ENSMUST00000128273.1
Fam131a
family with sequence similarity 131, member A
chr1_-_140183404 0.289 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr2_+_30952955 0.286 ENSMUST00000028199.5
Tor1b
torsin family 1, member B
chrX_-_134111852 0.276 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chrX_-_111697069 0.249 ENSMUST00000113422.2
ENSMUST00000038472.5
Hdx

highly divergent homeobox

chr13_+_58281183 0.227 ENSMUST00000180882.1
ENSMUST00000180452.1
Gm26555

predicted gene, 26555

chr5_-_92348871 0.220 ENSMUST00000038816.6
ENSMUST00000118006.1
Cxcl10

chemokine (C-X-C motif) ligand 10

chr16_+_44943737 0.187 ENSMUST00000114622.3
ENSMUST00000166731.1
Cd200r3

CD200 receptor 3

chr1_-_139377041 0.184 ENSMUST00000059825.5
Crb1
crumbs homolog 1 (Drosophila)
chr8_-_54724474 0.159 ENSMUST00000175915.1
Wdr17
WD repeat domain 17
chrX_-_10216918 0.148 ENSMUST00000072393.2
ENSMUST00000044598.6
ENSMUST00000073392.4
ENSMUST00000115533.1
ENSMUST00000115532.1
Rpgr




retinitis pigmentosa GTPase regulator




chr13_-_66852017 0.132 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr1_-_24612700 0.087 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr15_+_39006272 0.086 ENSMUST00000179165.1
ENSMUST00000022906.7
Fzd6

frizzled homolog 6 (Drosophila)

chr7_+_121707189 0.083 ENSMUST00000065310.2
1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr2_+_65620829 0.065 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0008065 establishment of blood-nerve barrier(GO:0008065) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.1 3.4 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.6 2.5 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.6 4.3 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.3 0.9 GO:1905154 negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154)
0.3 3.2 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.3 2.8 GO:0061032 visceral serous pericardium development(GO:0061032)
0.2 0.5 GO:2000569 T-helper 2 cell activation(GO:0035712) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.2 1.1 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.1 0.4 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.7 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 1.0 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1 2.6 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 1.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.9 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.1 0.3 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.1 0.9 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.2 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 2.7 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.1 0.6 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 2.8 GO:0071398 cellular response to fatty acid(GO:0071398)
0.1 3.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.4 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.1 2.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 1.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.5 GO:0035989 tendon development(GO:0035989)
0.1 0.3 GO:0045113 integrin biosynthetic process(GO:0045112) regulation of integrin biosynthetic process(GO:0045113)
0.1 0.5 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 0.8 GO:0097186 amelogenesis(GO:0097186)
0.1 1.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0035880 cell proliferation in midbrain(GO:0033278) nail development(GO:0035878) embryonic nail plate morphogenesis(GO:0035880)
0.0 3.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 1.0 GO:0010107 potassium ion import(GO:0010107)
0.0 1.0 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.7 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.4 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.6 GO:0007097 nuclear migration(GO:0007097)
0.0 0.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.9 GO:0050810 regulation of steroid biosynthetic process(GO:0050810)
0.0 3.4 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 0.8 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.1 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.9 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 1.9 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 0.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 1.9 GO:0044292 dendrite terminus(GO:0044292)
0.1 2.8 GO:0002102 podosome(GO:0002102)
0.1 0.5 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 1.0 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.3 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.1 0.9 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 4.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.2 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.7 4.3 GO:0015265 urea channel activity(GO:0015265)
0.7 2.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.6 2.5 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.3 3.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 5.0 GO:0017166 dystroglycan binding(GO:0002162) vinculin binding(GO:0017166)
0.3 0.8 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.2 4.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.2 1.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 1.1 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.2 0.8 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 0.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 2.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.2 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 2.7 GO:0043422 protein kinase B binding(GO:0043422)
0.1 3.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 4.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.9 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.3 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 1.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 3.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 2.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.6 GO:0034711 inhibin binding(GO:0034711)
0.1 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 0.4 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 1.0 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.9 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)