Motif ID: Hsf1

Z-value: 0.684


Transcription factors associated with Hsf1:

Gene SymbolEntrez IDGene Name
Hsf1 ENSMUSG00000022556.9 Hsf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf1mm10_v2_chr15_+_76477404_764774610.106.0e-01Click!


Activity profile for motif Hsf1.

activity profile for motif Hsf1


Sorted Z-values histogram for motif Hsf1

Sorted Z-values for motif Hsf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 109 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48667508 6.339 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr6_-_128438673 4.040 ENSMUST00000032508.4
 Fkbp4
FK506 binding protein 4
chr9_+_40801235 3.961 ENSMUST00000117870.1
ENSMUST00000117557.1
 Hspa8

heat shock protein 8

chr5_-_149636164 3.808 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chr19_-_7039987 3.415 ENSMUST00000025918.7
 Stip1
stress-induced phosphoprotein 1
chr7_-_99353104 2.792 ENSMUST00000169437.1
ENSMUST00000094154.4
 Serpinh1

serine (or cysteine) peptidase inhibitor, clade H, member 1

chrX_+_71663665 2.639 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50
chr2_+_120463566 2.475 ENSMUST00000028749.7
ENSMUST00000110721.1
 Capn3

calpain 3

chr5_-_149636331 2.382 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
 Hsph1



heat shock 105kDa/110kDa protein 1



chr12_+_117843873 2.137 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr15_-_31601506 2.116 ENSMUST00000161266.1
 Cct5
chaperonin containing Tcp1, subunit 5 (epsilon)
chr17_-_45572495 2.059 ENSMUST00000130406.1
 Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr7_-_70366735 1.977 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr6_+_128438757 1.931 ENSMUST00000144745.1
 Gm10069
predicted gene 10069
chr11_-_116843449 1.780 ENSMUST00000047616.3
 Jmjd6
jumonji domain containing 6
chr11_+_22990519 1.714 ENSMUST00000173867.1
ENSMUST00000020562.4
 Cct4

chaperonin containing Tcp1, subunit 4 (delta)

chr11_+_49609263 1.612 ENSMUST00000020617.2
 Flt4
FMS-like tyrosine kinase 4
chr5_+_129787390 1.536 ENSMUST00000031402.8
 Cct6a
chaperonin containing Tcp1, subunit 6a (zeta)
chr15_-_31601786 1.465 ENSMUST00000022842.8
 Cct5
chaperonin containing Tcp1, subunit 5 (epsilon)
chr17_+_47593444 1.441 ENSMUST00000182209.1
 Ccnd3
cyclin D3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.2 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
1.6 6.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.5 6.2 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
1.3 4.0 GO:1903054 lysosomal membrane organization(GO:0097212) negative regulation of extracellular matrix organization(GO:1903054) positive regulation of protein folding(GO:1903334)
0.2 4.0 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.6 3.8 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.5 2.8 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.8 2.5 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.7 2.1 GO:0097278 complement-dependent cytotoxicity(GO:0097278)
0.4 2.0 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.5 1.9 GO:0030576 Cajal body organization(GO:0030576)
0.1 1.9 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.3 1.8 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.2 1.8 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.1 1.6 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.5 1.5 GO:0002842 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.2 1.4 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 1.4 GO:0045116 protein neddylation(GO:0045116)
0.1 1.3 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.3 1.2 GO:0060032 notochord regression(GO:0060032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.8 5.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 4.3 GO:0030426 growth cone(GO:0030426)
1.0 4.0 GO:0043202 lysosomal lumen(GO:0043202)
0.1 4.0 GO:0044295 axonal growth cone(GO:0044295)
0.0 2.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.5 GO:0030315 T-tubule(GO:0030315)
0.1 1.9 GO:0015030 Cajal body(GO:0015030)
0.0 1.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.8 GO:0044452 nucleolar part(GO:0044452)
0.3 1.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.2 GO:0097542 ciliary tip(GO:0097542)
0.0 1.1 GO:0031985 Golgi cisterna(GO:0031985)
0.5 1.0 GO:0097512 cardiac myofibril(GO:0097512)
0.3 1.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.9 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 0.8 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 0.7 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 6.2 GO:0043014 alpha-tubulin binding(GO:0043014)
1.0 5.9 GO:0002135 CTP binding(GO:0002135)
1.3 4.0 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.8 4.0 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 3.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 3.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.9 2.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.3 2.5 GO:0031432 titin binding(GO:0031432)
0.2 2.0 GO:0001972 retinoic acid binding(GO:0001972)
0.6 1.9 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.0 1.9 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.6 1.8 GO:0032564 dATP binding(GO:0032564)
0.4 1.8 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.2 1.6 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.4 1.5 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.2 1.5 GO:0043559 insulin binding(GO:0043559)
0.2 1.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 1.4 GO:0019788 NEDD8 transferase activity(GO:0019788)