Motif ID: Hsf2

Z-value: 2.302


Transcription factors associated with Hsf2:

Gene SymbolEntrez IDGene Name
Hsf2 ENSMUSG00000019878.7 Hsf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf2mm10_v2_chr10_+_57486354_57486414-0.741.0e-06Click!


Activity profile for motif Hsf2.

activity profile for motif Hsf2


Sorted Z-values histogram for motif Hsf2

Sorted Z-values for motif Hsf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48667508 14.891 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr17_-_70851189 12.035 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr2_+_120463566 10.706 ENSMUST00000028749.7
ENSMUST00000110721.1
 Capn3

calpain 3

chr14_+_19751257 10.194 ENSMUST00000022340.3
 Nid2
nidogen 2
chr17_-_25797032 9.859 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr17_-_70849644 9.683 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr12_-_56536895 9.253 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr10_-_92164666 9.233 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr11_+_120949053 8.045 ENSMUST00000154187.1
ENSMUST00000100130.3
ENSMUST00000129473.1
ENSMUST00000168579.1
 Slc16a3



solute carrier family 16 (monocarboxylic acid transporters), member 3



chr9_+_65141154 7.993 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr13_+_98354234 7.873 ENSMUST00000105098.3
 Foxd1
forkhead box D1
chr1_-_72874877 7.766 ENSMUST00000027377.8
 Igfbp5
insulin-like growth factor binding protein 5
chr7_-_4752972 7.209 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chrX_-_75843063 6.849 ENSMUST00000114057.1
 Pls3
plastin 3 (T-isoform)
chr11_-_11970540 6.813 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr17_-_58991343 6.729 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr12_-_10900296 6.669 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr5_-_24730635 6.643 ENSMUST00000068693.5
 Wdr86
WD repeat domain 86
chr6_-_119467210 6.643 ENSMUST00000118120.1
 Wnt5b
wingless-related MMTV integration site 5B
chr1_+_12692430 6.578 ENSMUST00000180062.1
ENSMUST00000177608.1
 Sulf1

sulfatase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 280 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 26.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.7 14.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.8 14.3 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.5 13.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 13.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.8 11.2 GO:0030238 male sex determination(GO:0030238)
3.6 10.7 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 9.9 GO:0007160 cell-matrix adhesion(GO:0007160)
3.1 9.3 GO:0021759 globus pallidus development(GO:0021759)
0.1 9.2 GO:0007601 visual perception(GO:0007601)
1.8 9.1 GO:2000981 negative regulation of mechanoreceptor differentiation(GO:0045632) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.2 8.7 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 8.7 GO:0050772 positive regulation of axonogenesis(GO:0050772)
1.7 8.5 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
1.7 8.3 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 8.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
2.6 7.9 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.4 7.9 GO:0045793 positive regulation of cell size(GO:0045793)
1.1 7.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.4 7.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 33.1 GO:0005739 mitochondrion(GO:0005739)
0.0 16.7 GO:0009986 cell surface(GO:0009986)
0.3 16.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 15.6 GO:0005604 basement membrane(GO:0005604)
0.2 12.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 9.1 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
2.9 8.6 GO:0097512 cardiac myofibril(GO:0097512)
0.1 8.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 8.1 GO:0005667 transcription factor complex(GO:0005667)
1.9 7.8 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1 7.7 GO:0016459 myosin complex(GO:0016459)
0.2 7.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.6 7.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 6.6 GO:0005802 trans-Golgi network(GO:0005802)
0.1 6.4 GO:0031985 Golgi cisterna(GO:0031985)
0.8 6.3 GO:0005818 aster(GO:0005818)
0.6 6.2 GO:0031080 nuclear pore outer ring(GO:0031080)
1.0 5.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.7 5.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.9 5.6 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 26.6 GO:0070410 co-SMAD binding(GO:0070410)
0.1 18.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 16.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 12.2 GO:0051015 actin filament binding(GO:0051015)
0.5 11.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 11.6 GO:0071837 HMG box domain binding(GO:0071837)
1.3 10.7 GO:0031432 titin binding(GO:0031432)
3.5 10.6 GO:0005118 sevenless binding(GO:0005118)
0.8 10.6 GO:0008301 DNA binding, bending(GO:0008301)
0.3 10.1 GO:0005112 Notch binding(GO:0005112)
0.8 9.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 9.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 9.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 9.0 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.2 8.6 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.1 8.4 GO:0008237 metallopeptidase activity(GO:0008237)
1.2 8.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 8.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.6 8.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.5 8.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)