Motif ID: Hsf4

Z-value: 0.873


Transcription factors associated with Hsf4:

Gene SymbolEntrez IDGene Name
Hsf4 ENSMUSG00000033249.4 Hsf4



Activity profile for motif Hsf4.

activity profile for motif Hsf4


Sorted Z-values histogram for motif Hsf4

Sorted Z-values for motif Hsf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_194938821 2.349 ENSMUST00000016638.2
ENSMUST00000110815.2
 Cd34

CD34 antigen

chr12_+_75308308 1.902 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chrX_+_71663665 1.642 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50
chr7_-_19310035 1.497 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr19_-_5802640 1.359 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr12_-_110696332 1.309 ENSMUST00000094361.4
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr11_-_90002881 1.229 ENSMUST00000020864.8
 Pctp
phosphatidylcholine transfer protein
chr15_+_75704280 1.218 ENSMUST00000121137.1
ENSMUST00000023244.5
 Rhpn1

rhophilin, Rho GTPase binding protein 1

chr7_-_120982260 1.201 ENSMUST00000033169.8
 Cdr2
cerebellar degeneration-related 2
chr1_-_79858627 1.120 ENSMUST00000027467.4
 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr2_+_121456963 1.118 ENSMUST00000126764.1
 Hypk
huntingtin interacting protein K
chr17_+_47593444 1.101 ENSMUST00000182209.1
 Ccnd3
cyclin D3
chr6_-_128438673 1.058 ENSMUST00000032508.4
 Fkbp4
FK506 binding protein 4
chrX_-_106255367 1.044 ENSMUST00000091282.4
 Fnd3c2
fibronectin type III domain containing 3C2
chr18_-_10706688 1.031 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
 Abhd3


abhydrolase domain containing 3


chr14_-_48667508 1.020 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr17_-_50094277 1.015 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr12_-_110696289 1.007 ENSMUST00000021698.6
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr17_+_35439155 0.999 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr3_-_107943390 0.973 ENSMUST00000106681.1
 Gstm6
glutathione S-transferase, mu 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.7 4.1 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.5 2.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.8 2.3 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 1.9 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.2 1.7 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.1 1.6 GO:0070986 left/right axis specification(GO:0070986)
0.1 1.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 1.5 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 1.5 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 1.4 GO:0035063 nuclear speck organization(GO:0035063)
0.0 1.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.2 GO:0015914 phospholipid transport(GO:0015914)
0.4 1.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.2 1.1 GO:1905049 negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.1 1.1 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 1.1 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.3 1.0 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 1.0 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 1.0 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.1 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.3 4.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 3.1 GO:0046930 pore complex(GO:0046930)
0.0 1.9 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0005604 basement membrane(GO:0005604)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 1.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.3 GO:0015030 Cajal body(GO:0015030)
0.1 1.1 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.9 GO:0031201 SNARE complex(GO:0031201)
0.0 0.9 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.3 0.8 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.8 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.8 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.1 GO:0030911 TPR domain binding(GO:0030911)
0.3 4.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.3 2.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 1.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.5 1.5 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 1.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.5 1.4 GO:0005118 sevenless binding(GO:0005118)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.2 1.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 1.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.3 1.0 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.3 1.0 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 1.0 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.0 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.3 0.9 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.2 0.9 GO:0004046 aminoacylase activity(GO:0004046)