Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 3.473


Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770458_537705090.308.6e-02Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.271.2e-01Click!
Irf9mm10_v2_chr14_+_55604550_55604579-0.202.6e-01Click!
Irf2mm10_v2_chr8_+_46739745_46739791-0.134.6e-01Click!
Irf7mm10_v2_chr7_-_141266415_141266481-0.125.1e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 39.142 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr9_+_3034599 38.445 ENSMUST00000178641.1
Gm17535
predicted gene, 17535
chr9_+_3023547 36.371 ENSMUST00000099046.3
Gm10718
predicted gene 10718
chr9_+_3027439 35.518 ENSMUST00000177875.1
ENSMUST00000179982.1
Gm10717

predicted gene 10717

chr9_+_3004457 35.388 ENSMUST00000178348.1
Gm11168
predicted gene 11168
chr9_+_3015654 35.295 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr9_+_3017408 33.869 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr14_-_19418930 32.363 ENSMUST00000177817.1
Gm21738
predicted gene, 21738
chr9_+_3000922 32.310 ENSMUST00000151376.2
Gm10722
predicted gene 10722
chr2_-_98667264 32.089 ENSMUST00000099683.1
Gm10800
predicted gene 10800
chr9_+_3037111 31.861 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr9_+_3036877 30.544 ENSMUST00000155807.2
Gm10715
predicted gene 10715
chr9_+_3005125 30.524 ENSMUST00000179881.1
Gm11168
predicted gene 11168
chr9_+_3018753 29.500 ENSMUST00000179272.1
Gm10719
predicted gene 10719
chr9_+_3025417 28.116 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr2_+_98662227 15.408 ENSMUST00000099684.3
Gm10801
predicted gene 10801
chrX_-_134161928 13.521 ENSMUST00000033611.4
Xkrx
X Kell blood group precursor related X linked
chr2_+_122147680 12.070 ENSMUST00000102476.4
B2m
beta-2 microglobulin
chr2_-_105399286 11.351 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr7_-_102565425 9.127 ENSMUST00000106913.1
ENSMUST00000033264.4
Trim21

tripartite motif-containing 21


Gene overrepresentation in biological_process category:

Showing 1 to 20 of 321 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 15.8 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.6 11.8 GO:0042832 defense response to protozoan(GO:0042832)
0.9 10.3 GO:0044458 motile cilium assembly(GO:0044458)
1.8 9.1 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
1.1 8.5 GO:0048625 myoblast fate commitment(GO:0048625)
1.0 7.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.2 6.8 GO:0071346 cellular response to interferon-gamma(GO:0071346)
0.1 5.9 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.7 5.8 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
1.4 5.7 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.4 5.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
1.9 5.6 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.3 5.6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.7 5.5 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 5.5 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.1 5.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 5.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.7 4.7 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.8 4.6 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.3 4.6 GO:0097066 response to thyroid hormone(GO:0097066)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 164.0 GO:0005575 cellular_component(GO:0005575)
2.0 25.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.9 10.9 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 10.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 10.6 GO:0005667 transcription factor complex(GO:0005667)
0.1 10.0 GO:0036126 sperm flagellum(GO:0036126)
1.1 9.6 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 9.6 GO:0005604 basement membrane(GO:0005604)
0.9 8.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.7 5.9 GO:0030478 actin cap(GO:0030478)
1.9 5.7 GO:0070557 PCNA-p21 complex(GO:0070557)
1.4 5.6 GO:0097454 Schwann cell microvillus(GO:0097454)
0.9 5.5 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 5.3 GO:0030496 midbody(GO:0030496)
0.1 4.2 GO:0031519 PcG protein complex(GO:0031519)
0.3 4.1 GO:0043196 varicosity(GO:0043196)
0.2 4.1 GO:0030914 STAGA complex(GO:0030914)
0.4 4.0 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.2 3.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.5 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.9 12.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 11.0 GO:0003924 GTPase activity(GO:0003924)
0.4 10.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
1.9 9.5 GO:0032027 myosin light chain binding(GO:0032027)
0.4 8.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 7.9 GO:0001948 glycoprotein binding(GO:0001948)
0.2 6.6 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)
0.2 6.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 6.2 GO:0004386 helicase activity(GO:0004386)
2.0 6.1 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.0 6.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 6.0 GO:0003779 actin binding(GO:0003779)
0.2 5.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.5 5.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 5.3 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
1.2 5.0 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3 4.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 4.8 GO:0005525 GTP binding(GO:0005525)
0.4 4.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)