Motif ID: Irf3

Z-value: 0.659


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.202.7e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_142560052 2.116 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr3_+_142560108 2.014 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr3_+_81932601 1.838 ENSMUST00000029649.2
 Ctso
cathepsin O
chr3_+_142530329 1.827 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr7_-_104315455 1.805 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr3_+_142560351 1.786 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr6_-_39118211 1.535 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr13_+_74639866 1.318 ENSMUST00000169114.1
 Erap1
endoplasmic reticulum aminopeptidase 1
chr2_+_122147680 1.281 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr19_+_36409719 1.237 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr11_-_48871408 1.186 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr7_-_100514800 1.135 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr16_+_35938470 1.089 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr8_-_71537402 1.075 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr13_-_23710714 1.072 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr15_+_32920723 1.026 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr2_-_105399286 0.931 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr2_-_51934644 0.901 ENSMUST00000165313.1
 Rbm43
RNA binding motif protein 43
chrX_+_68678541 0.883 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr4_-_40239779 0.828 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr4_-_40239700 0.824 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chrX_+_68678712 0.796 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
 Fmr1



fragile X mental retardation syndrome 1



chr11_+_109362771 0.790 ENSMUST00000020930.7
ENSMUST00000106702.3
 Gna13

guanine nucleotide binding protein, alpha 13

chr7_-_102565425 0.723 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chrX_+_68678624 0.715 ENSMUST00000114656.1
 Fmr1
fragile X mental retardation syndrome 1
chr11_-_48871344 0.702 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr16_+_35938972 0.692 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr2_-_62646146 0.689 ENSMUST00000112459.3
ENSMUST00000028259.5
 Ifih1

interferon induced with helicase C domain 1

chr1_+_61638819 0.608 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr5_+_123252087 0.606 ENSMUST00000121964.1
 Wdr66
WD repeat domain 66
chr16_+_23609895 0.576 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr17_+_34187545 0.547 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_173276144 0.515 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr14_-_65833963 0.508 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr2_-_51934943 0.497 ENSMUST00000102767.1
ENSMUST00000102768.1
 Rbm43

RNA binding motif protein 43

chr11_+_72301613 0.434 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr14_+_14012491 0.433 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr17_+_34187789 0.428 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_75178911 0.423 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr2_+_152962485 0.395 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr17_+_75178797 0.389 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr6_-_23839137 0.354 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
 Cadps2







Ca2+-dependent activator protein for secretion 2







chr2_-_126933229 0.313 ENSMUST00000028844.4
 Sppl2a
signal peptide peptidase like 2A
chr16_-_10785525 0.306 ENSMUST00000038099.4
 Socs1
suppressor of cytokine signaling 1
chr18_-_32559914 0.291 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr11_+_119393060 0.288 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr6_-_54972603 0.250 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr10_-_81496329 0.245 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr16_-_35871544 0.244 ENSMUST00000042665.8
 Parp14
poly (ADP-ribose) polymerase family, member 14
chr10_-_81496313 0.234 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr11_+_58199556 0.224 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr5_+_114896936 0.209 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr7_-_116198487 0.200 ENSMUST00000181981.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr8_-_80739497 0.189 ENSMUST00000043359.8
 Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr19_-_44146433 0.165 ENSMUST00000079033.4
 Bloc1s2
biogenesis of lysosome-related organelles complex-1, subunit 2
chr17_+_57358682 0.132 ENSMUST00000086763.5
ENSMUST00000004850.7
 Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr19_+_43752996 0.129 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chr9_+_20868628 0.102 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr15_-_39112642 0.076 ENSMUST00000022908.8
 Slc25a32
solute carrier family 25, member 32
chr6_-_125231772 0.073 ENSMUST00000043422.7
 Tapbpl
TAP binding protein-like
chr12_+_70974621 0.072 ENSMUST00000160027.1
ENSMUST00000160864.1
 Psma3

proteasome (prosome, macropain) subunit, alpha type 3

chr2_-_145935014 0.070 ENSMUST00000001818.4
 Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr17_+_21008921 0.060 ENSMUST00000088811.5
 Zfp160
zinc finger protein 160
chr1_+_37890477 0.054 ENSMUST00000027256.5
 Mrpl30
mitochondrial ribosomal protein L30
chr16_-_19706365 0.054 ENSMUST00000081880.5
 Lamp3
lysosomal-associated membrane protein 3
chr10_+_83543941 0.030 ENSMUST00000038388.5
 A230046K03Rik
RIKEN cDNA A230046K03 gene
chr1_-_85109449 0.025 ENSMUST00000161724.1
 A530032D15Rik
RIKEN cDNA A530032D15Rik gene
chr11_-_116027961 0.020 ENSMUST00000106454.1
 H3f3b
H3 histone, family 3B
chr4_+_44012638 0.007 ENSMUST00000107847.3
ENSMUST00000170241.1
 Clta

clathrin, light polypeptide (Lca)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.5 7.7 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.5 2.4 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.4 1.7 GO:0009597 detection of virus(GO:0009597)
0.3 2.1 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.2 1.0 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.2 0.7 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.2 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 1.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.7 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.8 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 0.1 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.1 0.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.3 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.0 0.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.8 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.3 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.2 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.5 GO:0031648 protein destabilization(GO:0031648)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.7 7.7 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.3 0.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 2.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 0.2 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 1.0 GO:0042825 TAP complex(GO:0042825)
0.1 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.3 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.4 GO:0030914 STAGA complex(GO:0030914)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.1 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.1 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.9 GO:0005770 late endosome(GO:0005770)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 0.8 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.2 1.0 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.2 0.8 GO:0050436 microfibril binding(GO:0050436)
0.2 3.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 1.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.1 GO:0039706 co-receptor binding(GO:0039706)
0.1 1.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 5.7 GO:0003924 GTPase activity(GO:0003924)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.5 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.9 GO:0005525 GTP binding(GO:0005525)