Motif ID: Irf4

Z-value: 0.744


Transcription factors associated with Irf4:

Gene SymbolEntrez IDGene Name
Irf4 ENSMUSG00000021356.3 Irf4



Activity profile for motif Irf4.

activity profile for motif Irf4


Sorted Z-values histogram for motif Irf4

Sorted Z-values for motif Irf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_90537242 4.216 ENSMUST00000098911.3
S100a16
S100 calcium binding protein A16
chr3_+_90537306 4.111 ENSMUST00000107335.1
S100a16
S100 calcium binding protein A16
chr1_-_163313661 3.550 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr3_-_142395661 2.540 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
Pdlim5



PDZ and LIM domain 5



chr6_-_87335758 2.442 ENSMUST00000042025.9
Antxr1
anthrax toxin receptor 1
chr10_+_128706251 2.305 ENSMUST00000054125.8
Pmel
premelanosome protein
chr6_-_97060407 1.992 ENSMUST00000089295.4
Fam19a4
family with sequence similarity 19, member A4
chr6_-_39118211 1.898 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr19_-_24225015 1.873 ENSMUST00000099558.4
Tjp2
tight junction protein 2
chr6_+_82041623 1.869 ENSMUST00000042974.8
Eva1a
eva-1 homolog A (C. elegans)
chr19_-_58454580 1.859 ENSMUST00000129100.1
ENSMUST00000123957.1
Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr1_+_66468364 1.813 ENSMUST00000061620.9
Unc80
unc-80 homolog (C. elegans)
chr4_-_89311021 1.813 ENSMUST00000097981.4
Cdkn2b
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr10_+_94575257 1.794 ENSMUST00000121471.1
Tmcc3
transmembrane and coiled coil domains 3
chr1_+_61638819 1.768 ENSMUST00000138768.1
ENSMUST00000075374.3
Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr19_-_58455161 1.756 ENSMUST00000135730.1
ENSMUST00000152507.1
Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr14_-_66124482 1.724 ENSMUST00000070515.1
Ephx2
epoxide hydrolase 2, cytoplasmic
chr9_+_85842852 1.719 ENSMUST00000098500.3
Tpbg
trophoblast glycoprotein
chr11_-_77894096 1.716 ENSMUST00000017597.4
Pipox
pipecolic acid oxidase
chr19_-_58455398 1.624 ENSMUST00000026076.7
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 GO:0051592 response to calcium ion(GO:0051592)
0.3 3.6 GO:0048664 neuron fate determination(GO:0048664)
0.3 2.7 GO:0042447 hormone catabolic process(GO:0042447)
0.8 2.4 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.3 2.3 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.2 2.3 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.1 2.3 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.1 2.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 2.0 GO:0031670 cellular response to nutrient(GO:0031670)
0.5 1.9 GO:1903011 negative regulation of bone development(GO:1903011)
0.6 1.7 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.6 1.7 GO:0006553 lysine metabolic process(GO:0006553)
0.0 1.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 1.6 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.3 1.4 GO:0003430 tolerance induction to self antigen(GO:0002513) growth plate cartilage chondrocyte growth(GO:0003430)
0.2 1.4 GO:0033504 floor plate development(GO:0033504)
0.0 1.4 GO:0009411 response to UV(GO:0009411)
0.3 1.3 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.2 1.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.4 GO:0005730 nucleolus(GO:0005730)
0.0 5.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.7 GO:0005811 lipid particle(GO:0005811)
0.2 2.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.5 2.3 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 2.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.0 GO:0005901 caveola(GO:0005901)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.9 GO:0005921 gap junction(GO:0005921)
0.2 1.3 GO:0042825 TAP complex(GO:0042825)
0.0 1.3 GO:0097546 ciliary base(GO:0097546)
0.2 1.2 GO:1990357 terminal web(GO:1990357)
0.1 1.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.9 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.2 0.7 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.2 0.6 GO:0018444 translation release factor complex(GO:0018444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 5.2 GO:0005178 integrin binding(GO:0005178)
0.1 2.9 GO:0071837 HMG box domain binding(GO:0071837)
0.4 2.7 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 2.7 GO:0005518 collagen binding(GO:0005518)
0.1 2.5 GO:0042805 actinin binding(GO:0042805)
0.0 2.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.9 GO:0030674 protein binding, bridging(GO:0030674)
0.1 1.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 1.7 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.3 1.7 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.4 1.6 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3 1.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 1.3 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.1 1.2 GO:0039706 co-receptor binding(GO:0039706)
0.1 1.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)