Motif ID: Irf5_Irf6

Z-value: 0.821

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6



Activity profile for motif Irf5_Irf6.

activity profile for motif Irf5_Irf6


Sorted Z-values histogram for motif Irf5_Irf6

Sorted Z-values for motif Irf5_Irf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 64 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_142395661 6.333 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
 Pdlim5



PDZ and LIM domain 5



chr7_-_141010759 5.756 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr2_-_69586021 5.195 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
 Lrp2


low density lipoprotein receptor-related protein 2


chr17_+_23679363 4.045 ENSMUST00000024699.2
 Cldn6
claudin 6
chr11_+_88999376 3.568 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
 Trim25


tripartite motif-containing 25


chr9_+_45042425 3.181 ENSMUST00000034600.4
 Mpzl2
myelin protein zero-like 2
chr7_+_128523576 3.042 ENSMUST00000033136.7
 Bag3
BCL2-associated athanogene 3
chr1_-_163313661 2.849 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr19_+_55741810 2.645 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr9_-_14381242 2.047 ENSMUST00000167549.1
 Endod1
endonuclease domain containing 1
chr4_-_40239779 1.795 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_39118211 1.506 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr11_+_69966896 1.499 ENSMUST00000151515.1
 Cldn7
claudin 7
chr4_-_40239700 1.364 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr5_+_92809372 1.231 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr15_+_9436028 1.159 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr16_-_5255923 1.116 ENSMUST00000139584.1
ENSMUST00000064635.5
 Fam86

family with sequence similarity 86

chr6_+_57580992 1.111 ENSMUST00000031817.8
 Herc6
hect domain and RLD 6
chr9_+_57072024 1.048 ENSMUST00000169879.1
 Sin3a
transcriptional regulator, SIN3A (yeast)
chrX_+_77511002 1.025 ENSMUST00000088217.5
 Tbl1x
transducin (beta)-like 1 X-linked

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.2 6.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 5.2 GO:0045056 transcytosis(GO:0045056)
0.0 4.0 GO:0045216 cell-cell junction organization(GO:0045216)
0.8 3.2 GO:0009597 detection of virus(GO:0009597)
0.1 3.0 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.2 2.8 GO:0048664 neuron fate determination(GO:0048664)
0.0 2.7 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.3 2.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 1.7 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 1.5 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 1.2 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.3 1.0 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 1.0 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.1 1.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.0 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 1.0 GO:0043627 response to estrogen(GO:0043627)
0.2 0.8 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 0.8 GO:0046654 'de novo' IMP biosynthetic process(GO:0006189) tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.8 GO:0051642 centrosome localization(GO:0051642)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 GO:0030018 Z disc(GO:0030018)
0.0 6.6 GO:0045177 apical part of cell(GO:0045177)
0.3 6.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 5.2 GO:0031526 brush border membrane(GO:0031526)
0.0 3.2 GO:0032587 ruffle membrane(GO:0032587)
0.3 2.6 GO:0071664 beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664)
0.1 1.0 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.0 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.0 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.0 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.1 0.6 GO:0042825 TAP complex(GO:0042825)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.3 GO:0005771 multivesicular body(GO:0005771)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 GO:0042805 actinin binding(GO:0042805)
1.0 5.2 GO:0030492 hemoglobin binding(GO:0030492)
0.3 3.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 3.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 3.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.5 3.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 2.8 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 2.0 GO:0004519 endonuclease activity(GO:0004519)
0.0 1.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.1 GO:0030332 cyclin binding(GO:0030332)
0.0 1.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.3 0.8 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637)
0.0 0.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 0.6 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.1 0.6 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.1 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)