Motif ID: Irx5

Z-value: 0.368


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.335.9e-02Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 66 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_55598917 1.164 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr5_+_139543889 1.109 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_79908428 0.793 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr7_-_114927726 0.728 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chr10_+_97565436 0.638 ENSMUST00000038160.4
 Lum
lumican
chr2_-_79908389 0.601 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr9_-_78378725 0.514 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr16_+_30065333 0.471 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr2_-_85035487 0.412 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr6_+_50110837 0.392 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr3_+_95124476 0.357 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr5_+_48242549 0.334 ENSMUST00000172493.1
 Slit2
slit homolog 2 (Drosophila)
chr12_-_108893197 0.322 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr10_+_11609256 0.297 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr10_-_99759658 0.295 ENSMUST00000056085.4
 Csl
citrate synthase like
chr5_-_88675190 0.290 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr17_+_50698525 0.270 ENSMUST00000061681.7
 Gm7334
predicted gene 7334
chr10_+_3872667 0.257 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr1_+_165301863 0.238 ENSMUST00000178700.1
 Gpr161
G protein-coupled receptor 161
chr2_+_25180737 0.230 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 0.6 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 0.5 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.5 GO:0007566 embryo implantation(GO:0007566)
0.1 0.4 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.3 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.2 GO:0010986 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) positive regulation of lipoprotein particle clearance(GO:0010986)
0.0 0.2 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 0.2 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.2 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.2 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.0 GO:0044298 cell body membrane(GO:0044298)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.3 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)