Motif ID: Irx6_Irx2_Irx3

Z-value: 0.939

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx3mm10_v2_chr8_-_91801948_918020670.484.6e-03Click!
Irx6mm10_v2_chr8_+_92674289_926742890.383.0e-02Click!
Irx2mm10_v2_chr13_+_72628831_72628971-0.222.1e-01Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 12.038 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr10_+_26229707 6.014 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr10_-_29699379 4.061 ENSMUST00000092620.4
 Gm10275
predicted pseudogene 10275
chr11_-_76399107 3.485 ENSMUST00000021204.3
 Nxn
nucleoredoxin
chr7_-_103843154 2.808 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr16_+_17146937 2.801 ENSMUST00000115706.1
ENSMUST00000069064.4
 Ydjc

YdjC homolog (bacterial)

chr7_+_140763739 2.677 ENSMUST00000026552.7
 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr2_-_98667264 2.235 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr17_-_57839233 2.144 ENSMUST00000095218.3
 Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chr5_-_117389029 2.107 ENSMUST00000111953.1
ENSMUST00000086461.6
 Rfc5

replication factor C (activator 1) 5

chr9_+_64173364 1.990 ENSMUST00000034966.7
 Rpl4
ribosomal protein L4
chr11_-_26591729 1.867 ENSMUST00000109504.1
 Vrk2
vaccinia related kinase 2
chr2_-_169587745 1.807 ENSMUST00000109160.2
 Gm11011
predicted gene 11011
chr7_+_67647405 1.710 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr3_-_57651667 1.705 ENSMUST00000160959.1
 Commd2
COMM domain containing 2
chr2_-_67433181 1.702 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr19_+_20601958 1.627 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr5_-_129623655 1.601 ENSMUST00000076842.5
 Gm6139
predicted gene 6139
chr3_-_150073620 1.527 ENSMUST00000057740.5
 Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr17_+_46496753 1.492 ENSMUST00000046497.6
 Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 12.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 3.2 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.6 2.8 GO:0015671 oxygen transport(GO:0015671)
0.2 2.6 GO:0017144 drug metabolic process(GO:0017144)
0.1 2.2 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.3 2.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 2.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 1.9 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 1.9 GO:0007052 mitotic spindle organization(GO:0007052)
0.2 1.7 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.4 1.6 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 1.5 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.2 1.5 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 1.5 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 1.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.3 GO:0051297 centrosome organization(GO:0051297)
0.0 1.2 GO:2001022 positive regulation of response to DNA damage stimulus(GO:2001022)
0.1 1.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 1.1 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 1.1 GO:0007051 spindle organization(GO:0007051)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 12.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 6.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.8 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.3 2.4 GO:0005833 hemoglobin complex(GO:0005833)
0.4 2.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 2.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.0 GO:0031672 A band(GO:0031672)
0.2 1.9 GO:0005687 U4 snRNP(GO:0005687)
0.0 1.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.5 GO:0005819 spindle(GO:0005819)
0.2 1.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 1.2 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.1 GO:0000922 spindle pole(GO:0000922)
0.0 1.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.3 1.0 GO:0000801 central element(GO:0000801)
0.1 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.3 0.8 GO:0043512 inhibin A complex(GO:0043512)
0.1 0.8 GO:1990023 mitotic spindle midzone(GO:1990023)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 4.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.9 3.5 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 2.8 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.3 2.7 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.1 2.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.6 2.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 2.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 2.0 GO:0008097 5S rRNA binding(GO:0008097)
0.3 1.6 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 1.5 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.1 1.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 1.1 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 1.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 0.9 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)