Motif ID: Isl1

Z-value: 0.284


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_116309699-0.354.5e-02Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 112 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_37824580 0.806 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr1_+_12718496 0.541 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr2_+_120476911 0.494 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
 Capn3



calpain 3



chr7_+_45017953 0.487 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr12_-_73047179 0.409 ENSMUST00000050029.7
 Six1
sine oculis-related homeobox 1
chr19_+_55741810 0.406 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr15_-_50889691 0.392 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chrX_+_96455359 0.294 ENSMUST00000033553.7
 Heph
hephaestin
chr18_-_47333311 0.293 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr14_-_12345847 0.277 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr15_-_93519499 0.269 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr19_+_55742242 0.264 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr9_-_112187898 0.253 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr7_-_25250720 0.237 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chrX_+_56779437 0.236 ENSMUST00000114773.3
 Fhl1
four and a half LIM domains 1
chr4_+_154960915 0.235 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr9_+_53771499 0.234 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr10_-_13388753 0.228 ENSMUST00000105546.1
 Phactr2
phosphatase and actin regulator 2
chr4_+_94739276 0.228 ENSMUST00000073939.6
ENSMUST00000102798.1
 Tek

endothelial-specific receptor tyrosine kinase

chr8_-_61902669 0.228 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 0.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.2 0.5 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.5 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.4 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1 0.3 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.0 0.3 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.3 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.2 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.2 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 0.2 GO:0010668 ectodermal cell differentiation(GO:0010668)

Gene overrepresentation in cellular_component category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.0 GO:0019815 B cell receptor complex(GO:0019815)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.5 GO:0031432 titin binding(GO:0031432)
0.1 0.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.2 GO:0019808 polyamine binding(GO:0019808)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.2 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.0 GO:0015217 ADP transmembrane transporter activity(GO:0015217) coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)