Motif ID: Isl1

Z-value: 0.284


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_116309699-0.354.5e-02Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_37824580 0.806 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr1_+_12718496 0.541 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr2_+_120476911 0.494 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr7_+_45017953 0.487 ENSMUST00000044111.7
Rras
Harvey rat sarcoma oncogene, subgroup R
chr12_-_73047179 0.409 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr19_+_55741810 0.406 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr15_-_50889691 0.392 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chrX_+_96455359 0.294 ENSMUST00000033553.7
Heph
hephaestin
chr18_-_47333311 0.293 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr14_-_12345847 0.277 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr15_-_93519499 0.269 ENSMUST00000109255.2
Prickle1
prickle homolog 1 (Drosophila)
chr19_+_55742242 0.264 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr9_-_112187898 0.253 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr7_-_25250720 0.237 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chrX_+_56779437 0.236 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr4_+_154960915 0.235 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr9_+_53771499 0.234 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr10_-_13388753 0.228 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chr4_+_94739276 0.228 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr8_-_61902669 0.228 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr4_-_42661893 0.225 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr10_-_35711891 0.223 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr19_+_55742056 0.220 ENSMUST00000111659.2
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr4_-_42168603 0.219 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr19_+_55741884 0.205 ENSMUST00000111658.3
ENSMUST00000111654.1
Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chr2_-_72986716 0.204 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr13_+_63282142 0.202 ENSMUST00000159152.1
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr4_+_41903610 0.200 ENSMUST00000098128.3
Gm21541
predicted gene, 21541
chrX_+_169879596 0.198 ENSMUST00000112105.1
ENSMUST00000078947.5
Mid1

midline 1

chr12_+_69963452 0.197 ENSMUST00000110560.1
Gm3086
predicted gene 3086
chr4_+_3940747 0.191 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr8_-_71511762 0.189 ENSMUST00000048452.4
Plvap
plasmalemma vesicle associated protein
chr1_-_183147461 0.189 ENSMUST00000171366.1
Disp1
dispatched homolog 1 (Drosophila)
chr15_+_44196135 0.177 ENSMUST00000038856.6
ENSMUST00000110289.3
Trhr

thyrotropin releasing hormone receptor

chr16_-_22161450 0.172 ENSMUST00000115379.1
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chrX_+_99975570 0.169 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr2_+_109917639 0.166 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr19_+_24875679 0.166 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr1_-_89933290 0.165 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr2_-_127788854 0.160 ENSMUST00000028857.7
ENSMUST00000110357.1
Nphp1

nephronophthisis 1 (juvenile) homolog (human)

chr4_-_14621669 0.159 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr13_-_103764502 0.158 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr15_+_62037986 0.146 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
Pvt1




plasmacytoma variant translocation 1




chr10_-_128176568 0.142 ENSMUST00000092033.2
Rbms2
RNA binding motif, single stranded interacting protein 2
chr4_-_120951664 0.138 ENSMUST00000106280.1
Zfp69
zinc finger protein 69
chr8_+_25720054 0.134 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr6_-_24956106 0.131 ENSMUST00000127247.2
Tmem229a
transmembrane protein 229A
chr14_-_118052235 0.128 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr14_-_96519067 0.128 ENSMUST00000022666.7
Klhl1
kelch-like 1
chr9_-_37147257 0.127 ENSMUST00000039674.5
ENSMUST00000080754.5
Pknox2

Pbx/knotted 1 homeobox 2

chr19_+_3986564 0.126 ENSMUST00000054030.7
Acy3
aspartoacylase (aminoacylase) 3
chr4_-_14621805 0.122 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr3_-_104818539 0.122 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Mov10



Moloney leukemia virus 10



chrX_+_106920618 0.114 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr6_-_144209448 0.112 ENSMUST00000077160.5
Sox5
SRY-box containing gene 5
chr6_-_13871477 0.111 ENSMUST00000139231.1
2610001J05Rik
RIKEN cDNA 2610001J05 gene
chr9_-_95815389 0.108 ENSMUST00000119760.1
Pls1
plastin 1 (I-isoform)
chr6_-_144209471 0.108 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr14_+_124005355 0.105 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr8_-_105568298 0.105 ENSMUST00000005849.5
Agrp
agouti related protein
chr6_-_144209558 0.102 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr9_+_94669876 0.102 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr15_-_50882806 0.100 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chr17_-_46680870 0.097 ENSMUST00000165007.1
ENSMUST00000071841.5
Klhdc3

kelch domain containing 3

chr3_-_150073620 0.096 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chrX_+_114474312 0.095 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4

kelch-like 4

chr13_+_63014934 0.095 ENSMUST00000091560.4
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr3_-_49757257 0.088 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr16_-_91069142 0.087 ENSMUST00000035689.1
ENSMUST00000114076.1
4932438H23Rik

RIKEN cDNA 4932438H23 gene

chr16_-_64786321 0.087 ENSMUST00000052588.4
Zfp654
zinc finger protein 654
chr1_-_10038106 0.084 ENSMUST00000027050.3
Cops5
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
chr3_-_57294880 0.083 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr4_-_42084291 0.075 ENSMUST00000177937.1
Gm21968
predicted gene, 21968
chr18_+_6332587 0.074 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr18_+_4375583 0.067 ENSMUST00000025077.6
Mtpap
mitochondrial poly(A) polymerase
chr7_-_118116171 0.066 ENSMUST00000131374.1
Rps15a
ribosomal protein S15A
chr17_+_46681038 0.065 ENSMUST00000002845.6
Mea1
male enhanced antigen 1
chr7_+_140763739 0.063 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr12_-_12941827 0.061 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr11_+_74649462 0.060 ENSMUST00000092915.5
ENSMUST00000117818.1
Cluh

clustered mitochondria (cluA/CLU1) homolog

chr7_+_51878967 0.058 ENSMUST00000051912.6
Gas2
growth arrest specific 2
chr4_-_137766474 0.058 ENSMUST00000139951.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr2_+_153161303 0.058 ENSMUST00000089027.2
Tm9sf4
transmembrane 9 superfamily protein member 4
chr4_-_82850721 0.058 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr15_-_50890396 0.054 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr7_+_51879041 0.053 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr15_-_27630644 0.051 ENSMUST00000059662.7
Fam105b
family with sequence similarity 105, member B
chr2_-_168955529 0.051 ENSMUST00000109162.2
Zfp64
zinc finger protein 64
chr2_+_121456963 0.050 ENSMUST00000126764.1
Hypk
huntingtin interacting protein K
chr3_+_32736990 0.048 ENSMUST00000127477.1
ENSMUST00000121778.1
ENSMUST00000154257.1
Ndufb5


NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5


chr12_-_113422730 0.047 ENSMUST00000177715.1
ENSMUST00000103426.1
Ighm

immunoglobulin heavy constant mu

chr2_-_169405435 0.045 ENSMUST00000131509.1
4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr15_-_81360739 0.044 ENSMUST00000023040.7
Slc25a17
solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
chr9_+_35423582 0.042 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr17_+_71204647 0.041 ENSMUST00000126681.1
Lpin2
lipin 2
chr4_-_14621494 0.040 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chrX_-_43274786 0.040 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr4_+_154964117 0.040 ENSMUST00000030931.4
ENSMUST00000070953.4
Pank4

pantothenate kinase 4

chr1_+_164503306 0.035 ENSMUST00000181831.1
Gm26685
predicted gene, 26685
chr1_+_132191436 0.034 ENSMUST00000112357.2
Lemd1
LEM domain containing 1
chr1_-_57970067 0.034 ENSMUST00000164963.1
Kctd18
potassium channel tetramerisation domain containing 18
chrX_-_153037549 0.031 ENSMUST00000051484.3
Mageh1
melanoma antigen, family H, 1
chr18_-_15718046 0.030 ENSMUST00000053017.6
Chst9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr7_-_118116128 0.029 ENSMUST00000128482.1
ENSMUST00000131840.1
Rps15a

ribosomal protein S15A

chr9_+_37367354 0.027 ENSMUST00000051839.7
Hepacam
hepatocyte cell adhesion molecule
chr1_-_57970104 0.026 ENSMUST00000114410.3
Kctd18
potassium channel tetramerisation domain containing 18
chr3_-_88552859 0.023 ENSMUST00000119002.1
ENSMUST00000029698.8
Lamtor2

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

chr5_-_103977360 0.017 ENSMUST00000048118.8
Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr3_+_88553716 0.016 ENSMUST00000008748.6
Ubqln4
ubiquilin 4
chr2_-_152398046 0.010 ENSMUST00000063332.8
ENSMUST00000182625.1
Sox12

SRY-box containing gene 12

chr3_-_95754841 0.008 ENSMUST00000029752.8
ENSMUST00000074339.6
ENSMUST00000163530.1
ENSMUST00000098857.4
Tars2



threonyl-tRNA synthetase 2, mitochondrial (putative)



chr6_+_30568367 0.006 ENSMUST00000049251.5
Cpa4
carboxypeptidase A4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.2 0.5 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 1.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.4 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.3 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.2 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.2 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 0.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.3 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.0 0.2 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.2 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.2 GO:0060539 diaphragm development(GO:0060539)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0032196 transposition(GO:0032196)
0.0 0.1 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.5 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:0043171 peptide catabolic process(GO:0043171)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.0 GO:0019815 B cell receptor complex(GO:0019815)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.5 GO:0031432 titin binding(GO:0031432)
0.1 0.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.2 GO:0019808 polyamine binding(GO:0019808)
0.0 1.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.0 GO:0015217 ADP transmembrane transporter activity(GO:0015217) coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)