Motif ID: Isl2

Z-value: 0.702


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_12718496 4.046 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr10_-_77166545 3.684 ENSMUST00000081654.6
 Col18a1
collagen, type XVIII, alpha 1
chr9_+_72806874 3.041 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr12_-_10900296 2.529 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr17_-_48432723 2.370 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr16_-_76403673 2.340 ENSMUST00000052867.7
 Gm9843
predicted gene 9843
chr9_+_53771499 2.110 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr9_-_100506844 1.986 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr4_+_3940747 1.906 ENSMUST00000119403.1
 Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr17_-_56005566 1.898 ENSMUST00000043785.6
 Stap2
signal transducing adaptor family member 2
chr17_+_17402672 1.848 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr8_+_121116163 1.839 ENSMUST00000054691.6
 Foxc2
forkhead box C2
chr9_+_108560422 1.804 ENSMUST00000081111.8
 Impdh2
inosine 5'-phosphate dehydrogenase 2
chr1_-_163289214 1.762 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chrX_+_96455359 1.732 ENSMUST00000033553.7
 Heph
hephaestin
chr14_+_27039001 1.714 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr8_-_61902669 1.633 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr10_-_61784014 1.577 ENSMUST00000020283.4
 H2afy2
H2A histone family, member Y2
chrX_+_136245065 1.570 ENSMUST00000048687.4
 Wbp5
WW domain binding protein 5
chr14_+_69347587 1.493 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.0 4.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 2.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 2.4 GO:0080111 DNA demethylation(GO:0080111)
0.7 2.1 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.5 2.0 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.6 1.8 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278) regulation of vascular wound healing(GO:0061043) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.3 1.8 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 1.8 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.8 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.7 GO:0006825 copper ion transport(GO:0006825)
0.3 1.6 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 1.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.5 1.5 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.2 1.5 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 1.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.5 1.4 GO:0009106 lipoate metabolic process(GO:0009106)
0.5 1.4 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.3 1.4 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0005581 collagen trimer(GO:0005581)
0.2 2.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 1.6 GO:0001740 Barr body(GO:0001740)
0.1 1.6 GO:0002102 podosome(GO:0002102)
0.4 1.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.5 GO:0000974 Prp19 complex(GO:0000974)
0.0 1.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 1.4 GO:0070826 paraferritin complex(GO:0070826)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 1.2 GO:0036156 inner dynein arm(GO:0036156)
0.0 1.1 GO:0030673 axolemma(GO:0030673)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.0 1.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 2.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 2.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.7 2.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.3 2.0 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.5 1.8 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 1.8 GO:0071837 HMG box domain binding(GO:0071837)
0.6 1.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 1.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 1.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.5 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 1.5 GO:0050699 WW domain binding(GO:0050699)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.3 1.4 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.4 GO:0016415 octanoyltransferase activity(GO:0016415)
0.2 1.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.1 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)