Motif ID: Isl2

Z-value: 0.702


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_12718496 4.046 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr10_-_77166545 3.684 ENSMUST00000081654.6
Col18a1
collagen, type XVIII, alpha 1
chr9_+_72806874 3.041 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr12_-_10900296 2.529 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr17_-_48432723 2.370 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr16_-_76403673 2.340 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr9_+_53771499 2.110 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr9_-_100506844 1.986 ENSMUST00000112874.3
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr4_+_3940747 1.906 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr17_-_56005566 1.898 ENSMUST00000043785.6
Stap2
signal transducing adaptor family member 2
chr17_+_17402672 1.848 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr8_+_121116163 1.839 ENSMUST00000054691.6
Foxc2
forkhead box C2
chr9_+_108560422 1.804 ENSMUST00000081111.8
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr1_-_163289214 1.762 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chrX_+_96455359 1.732 ENSMUST00000033553.7
Heph
hephaestin
chr14_+_27039001 1.714 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr8_-_61902669 1.633 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr10_-_61784014 1.577 ENSMUST00000020283.4
H2afy2
H2A histone family, member Y2
chrX_+_136245065 1.570 ENSMUST00000048687.4
Wbp5
WW domain binding protein 5
chr14_+_69347587 1.493 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr11_+_94327984 1.483 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40

ankyrin repeat domain 40

chr14_-_31323884 1.480 ENSMUST00000048603.7
Dnah1
dynein, axonemal, heavy chain 1
chr3_-_33082004 1.457 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr7_+_100159241 1.443 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr2_+_109917639 1.389 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr3_-_49757257 1.277 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr17_+_20570362 1.230 ENSMUST00000095633.3
Gm5145
predicted pseudogene 5145
chr6_-_136941887 1.205 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr9_-_90255927 1.199 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr17_-_26099257 1.163 ENSMUST00000053575.3
Gm8186
predicted gene 8186
chr17_+_12119274 1.146 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr8_+_114133635 1.121 ENSMUST00000147605.1
ENSMUST00000134593.1
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr4_-_86669492 1.114 ENSMUST00000149700.1
Plin2
perilipin 2
chr1_-_128102412 1.114 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3

zinc finger, RAN-binding domain containing 3

chr11_-_80779989 1.105 ENSMUST00000041065.7
ENSMUST00000070997.5
Myo1d

myosin ID

chr7_+_28881656 1.089 ENSMUST00000066880.4
Capn12
calpain 12
chr14_-_69707546 1.065 ENSMUST00000118374.1
R3hcc1
R3H domain and coiled-coil containing 1
chrX_-_60893430 1.065 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr5_-_87490869 1.037 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chrM_+_8600 1.026 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr17_-_53867041 1.024 ENSMUST00000061311.7
Mrps36-ps1
mitichondrial ribosomal protein S36, pseudogene 1
chr12_+_109546409 1.012 ENSMUST00000143847.1
Meg3
maternally expressed 3
chr15_-_10485385 1.000 ENSMUST00000168690.1
Brix1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
chr11_+_58171648 0.995 ENSMUST00000020820.1
Mrpl22
mitochondrial ribosomal protein L22
chr10_+_69208546 0.994 ENSMUST00000164034.1
Rhobtb1
Rho-related BTB domain containing 1
chr10_-_31445921 0.994 ENSMUST00000000305.5
Tpd52l1
tumor protein D52-like 1
chr8_+_114133557 0.977 ENSMUST00000073521.5
ENSMUST00000066514.6
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr4_+_136172367 0.974 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr14_-_69707493 0.969 ENSMUST00000121142.1
R3hcc1
R3H domain and coiled-coil containing 1
chr5_+_15516489 0.957 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chrM_+_9452 0.950 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr5_-_3647806 0.949 ENSMUST00000119783.1
ENSMUST00000007559.8
Gatad1

GATA zinc finger domain containing 1

chr14_-_104522615 0.939 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr4_-_136053343 0.879 ENSMUST00000102536.4
Rpl11
ribosomal protein L11
chr3_+_103171655 0.875 ENSMUST00000005830.8
Bcas2
breast carcinoma amplified sequence 2
chr2_+_125136692 0.855 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr2_+_115581667 0.836 ENSMUST00000166472.1
ENSMUST00000110918.2
BC052040

cDNA sequence BC052040

chr6_+_29859686 0.817 ENSMUST00000134438.1
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr1_-_172027269 0.817 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr11_-_82908360 0.816 ENSMUST00000103213.3
Nle1
notchless homolog 1 (Drosophila)
chr10_+_102158858 0.813 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr5_-_88675190 0.796 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr3_-_9004422 0.788 ENSMUST00000063496.7
Tpd52
tumor protein D52
chr12_-_99883429 0.749 ENSMUST00000046485.3
Efcab11
EF-hand calcium binding domain 11
chr13_-_58354862 0.718 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr15_-_10485890 0.716 ENSMUST00000169050.1
ENSMUST00000022855.5
Brix1

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)

chr1_-_185329331 0.701 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
Iars2


isoleucine-tRNA synthetase 2, mitochondrial


chr15_-_100424092 0.700 ENSMUST00000154676.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr2_+_163658370 0.699 ENSMUST00000164399.1
ENSMUST00000064703.6
ENSMUST00000099105.2
ENSMUST00000152418.1
ENSMUST00000126182.1
ENSMUST00000131228.1
Pkig





protein kinase inhibitor, gamma





chr3_+_89459118 0.680 ENSMUST00000029564.5
Pmvk
phosphomevalonate kinase
chr19_-_44552831 0.678 ENSMUST00000166808.1
Gm20538
predicted gene 20538
chr15_-_100424208 0.668 ENSMUST00000154331.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr19_+_5490475 0.655 ENSMUST00000116560.2
Cfl1
cofilin 1, non-muscle
chr19_+_25406661 0.654 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr9_+_70012540 0.639 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
Gtf2a2




general transcription factor II A, 2




chr14_+_58893465 0.622 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chrX_+_164373363 0.607 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr3_+_83055516 0.601 ENSMUST00000150268.1
ENSMUST00000122128.1
Plrg1

pleiotropic regulator 1, PRL1 homolog (Arabidopsis)

chr13_+_104229366 0.592 ENSMUST00000022227.6
Cenpk
centromere protein K
chr16_-_35939082 0.592 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr15_+_25773985 0.590 ENSMUST00000125667.1
Myo10
myosin X
chr10_-_80918212 0.589 ENSMUST00000057623.7
ENSMUST00000179022.1
Lmnb2

lamin B2

chr9_-_22117123 0.577 ENSMUST00000013966.6
Elof1
elongation factor 1 homolog (ELF1, S. cerevisiae)
chr1_-_9944103 0.572 ENSMUST00000182498.1
ENSMUST00000182742.1
ENSMUST00000182580.1
Snhg6


small nucleolar RNA host gene (non-protein coding) 6


chr2_-_73580288 0.566 ENSMUST00000028515.3
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr17_+_78916473 0.549 ENSMUST00000063817.4
ENSMUST00000180077.1
1110001A16Rik

RIKEN cDNA 1110001A16 gene

chr6_-_89595647 0.520 ENSMUST00000032172.8
ENSMUST00000113550.3
Chchd6

coiled-coil-helix-coiled-coil-helix domain containing 6

chr4_+_147507600 0.518 ENSMUST00000063704.7
Gm13152
predicted gene 13152
chr10_-_13324160 0.510 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr11_-_71004387 0.507 ENSMUST00000124464.1
ENSMUST00000108527.1
Dhx33

DEAH (Asp-Glu-Ala-His) box polypeptide 33

chr12_+_87443896 0.507 ENSMUST00000161023.1
ENSMUST00000160488.1
ENSMUST00000077462.7
ENSMUST00000160880.1
Slirp



SRA stem-loop interacting RNA binding protein



chr4_+_147492417 0.489 ENSMUST00000105721.2
Gm13152
predicted gene 13152
chr2_-_160619971 0.484 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr17_+_56613392 0.461 ENSMUST00000080492.5
Rpl36
ribosomal protein L36
chr15_+_10486008 0.454 ENSMUST00000022856.8
ENSMUST00000100775.3
ENSMUST00000169519.1
Rad1


RAD1 homolog (S. pombe)


chr9_+_96258697 0.439 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr15_-_35938186 0.437 ENSMUST00000014457.8
Cox6c
cytochrome c oxidase subunit VIc
chrY_-_1245753 0.430 ENSMUST00000154004.1
Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr1_+_187215501 0.427 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
Gpatch2



G patch domain containing 2



chr10_-_76110956 0.425 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr14_-_6411578 0.417 ENSMUST00000179312.1
Gm3591
predicted gene 3591
chr7_+_126976338 0.416 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr14_+_5517172 0.416 ENSMUST00000178220.1
Gm3488
predicted gene, 3488
chr14_+_5164535 0.416 ENSMUST00000179659.1
Gm3317
predicted gene 3317
chr3_+_138374121 0.403 ENSMUST00000171054.1
Adh6-ps1
alcohol dehydrogenase 6 (class V), pseudogene 1
chr14_+_4871156 0.403 ENSMUST00000166410.2
Gm3264
predicted gene 3264
chr1_-_72874877 0.396 ENSMUST00000027377.8
Igfbp5
insulin-like growth factor binding protein 5
chr5_-_24902315 0.389 ENSMUST00000131486.1
Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr18_-_34651703 0.388 ENSMUST00000025228.5
ENSMUST00000133181.1
Cdc23

CDC23 cell division cycle 23

chr14_-_6741430 0.378 ENSMUST00000100904.4
Gm3636
predicted gene 3636
chr11_+_5520652 0.375 ENSMUST00000063084.9
Xbp1
X-box binding protein 1
chr14_-_7473073 0.370 ENSMUST00000167833.2
Gm3752
predicted gene 3752
chr11_-_101278927 0.367 ENSMUST00000168089.1
ENSMUST00000017332.3
Coa3

cytochrome C oxidase assembly factor 3

chr14_+_4198185 0.360 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr14_+_3348089 0.353 ENSMUST00000178722.1
Gm2956
predicted gene 2956
chr3_+_41563356 0.351 ENSMUST00000163764.1
Phf17
PHD finger protein 17
chr1_+_132477361 0.351 ENSMUST00000027700.8
Rbbp5
retinoblastoma binding protein 5
chrM_+_3906 0.347 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr15_+_16778101 0.345 ENSMUST00000026432.6
Cdh9
cadherin 9
chr4_-_42661893 0.345 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr1_+_110099295 0.340 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr14_+_3428103 0.318 ENSMUST00000178060.1
Gm3005
predicted gene 3005
chr14_+_3667518 0.305 ENSMUST00000112801.3
Gm3020
predicted gene 3020
chr15_+_84232030 0.297 ENSMUST00000023072.6
Parvb
parvin, beta
chr17_-_56036546 0.297 ENSMUST00000003268.9
Sh3gl1
SH3-domain GRB2-like 1
chr19_+_8802486 0.293 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr12_-_87444017 0.286 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr14_+_4741737 0.284 ENSMUST00000178748.1
Gm3252
predicted gene 3252
chr14_+_4126066 0.282 ENSMUST00000167397.2
Gm8108
predicted gene 8108
chr10_-_127311740 0.279 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chr14_+_4665094 0.279 ENSMUST00000169675.2
Gm3239
predicted gene 3239
chr5_-_43981757 0.271 ENSMUST00000061299.7
Fgfbp1
fibroblast growth factor binding protein 1
chr4_+_145510759 0.267 ENSMUST00000105742.1
ENSMUST00000136309.1
Gm13225

predicted gene 13225

chr14_+_4430992 0.266 ENSMUST00000164603.1
ENSMUST00000166848.1
Gm3173

predicted gene 3173

chr13_+_48513570 0.262 ENSMUST00000065465.1
A830005F24Rik
RIKEN cDNA A830005F24 gene
chr14_-_19569553 0.259 ENSMUST00000112595.2
Gm2237
predicted gene 2237
chr14_+_3825596 0.250 ENSMUST00000178256.1
Gm3002
predicted gene 3002
chr15_-_35938009 0.248 ENSMUST00000156915.1
Cox6c
cytochrome c oxidase subunit VIc
chr14_-_6874257 0.241 ENSMUST00000178298.1
ENSMUST00000179374.1
Gm3667
Gm3629
predicted gene 3667
predicted gene 3629
chr10_-_63927434 0.240 ENSMUST00000079279.3
Gm10118
predicted gene 10118
chr9_-_102354685 0.234 ENSMUST00000035129.7
ENSMUST00000085169.5
Ephb1

Eph receptor B1

chr14_-_6266620 0.224 ENSMUST00000096172.5
Gm3411
predicted gene 3411
chr1_+_190928492 0.217 ENSMUST00000066632.7
ENSMUST00000110899.1
Angel2

angel homolog 2 (Drosophila)

chr7_-_6730412 0.215 ENSMUST00000051209.4
Peg3
paternally expressed 3
chr4_+_47386216 0.213 ENSMUST00000107725.2
Tgfbr1
transforming growth factor, beta receptor I
chr1_+_45981548 0.210 ENSMUST00000085632.2
Rpl23a-ps1
ribosomal protein 23A, pseudogene 1
chr3_-_79841729 0.207 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr17_+_82539258 0.202 ENSMUST00000097278.3
Gm6594
predicted pseudogene 6594
chr15_-_38078842 0.193 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr11_-_98729374 0.156 ENSMUST00000126565.1
ENSMUST00000100500.2
ENSMUST00000017354.6
Med24


mediator complex subunit 24


chr7_+_19119853 0.154 ENSMUST00000053109.3
Fbxo46
F-box protein 46
chr18_-_43477764 0.140 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr3_-_51408925 0.133 ENSMUST00000038108.6
Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr4_-_14621669 0.131 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr11_+_69838514 0.119 ENSMUST00000133967.1
ENSMUST00000094065.4
Tmem256

transmembrane protein 256

chr8_+_88118747 0.104 ENSMUST00000095214.3
Cnep1r1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr18_-_36766198 0.103 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chr10_-_85127977 0.099 ENSMUST00000050813.2
Mterfd3
MTERF domain containing 3
chr1_+_156838915 0.099 ENSMUST00000111720.1
Angptl1
angiopoietin-like 1
chr4_-_88722454 0.098 ENSMUST00000094993.2
Klhl9
kelch-like 9
chr14_-_5863663 0.097 ENSMUST00000178594.1
Gm8237
predicted gene 8237
chr4_+_32623985 0.090 ENSMUST00000108178.1
Casp8ap2
caspase 8 associated protein 2
chr17_+_56005672 0.087 ENSMUST00000133998.1
Mpnd
MPN domain containing
chr8_-_21906412 0.071 ENSMUST00000051965.4
Defb11
defensin beta 11
chr1_-_24612700 0.064 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr18_+_23753708 0.064 ENSMUST00000115830.1
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr1_-_139377094 0.060 ENSMUST00000131586.1
ENSMUST00000145244.1
Crb1

crumbs homolog 1 (Drosophila)

chr17_+_85028347 0.048 ENSMUST00000024944.7
Slc3a1
solute carrier family 3, member 1
chr19_+_5474681 0.029 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chrX_-_20931520 0.021 ENSMUST00000001156.7
Cfp
complement factor properdin
chr8_+_107031218 0.018 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chrX_-_150657366 0.007 ENSMUST00000148604.1
Tro
trophinin
chrX_+_73675500 0.005 ENSMUST00000171398.1
Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chrX_+_101449078 0.002 ENSMUST00000033674.5
Itgb1bp2
integrin beta 1 binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.7 2.1 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.6 1.8 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278) regulation of vascular wound healing(GO:0061043) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.5 1.5 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.5 2.0 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.5 1.4 GO:0009106 lipoate metabolic process(GO:0009106)
0.5 1.4 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.4 1.1 GO:0036292 DNA rewinding(GO:0036292)
0.3 1.0 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.3 1.8 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 1.4 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.3 0.8 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 1.6 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.2 1.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 0.7 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.2 4.1 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.2 0.7 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 1.5 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.2 1.0 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 0.7 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.1 2.4 GO:0080111 DNA demethylation(GO:0080111)
0.1 1.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 1.0 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.1 0.4 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.8 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 1.8 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.5 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1 1.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.8 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.7 GO:0006825 copper ion transport(GO:0006825)
0.1 0.6 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.7 GO:0001842 neural fold formation(GO:0001842)
0.1 2.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.8 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.5 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.1 0.4 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 1.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.2 GO:1902915 progesterone receptor signaling pathway(GO:0050847) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 1.1 GO:0007530 sex determination(GO:0007530)
0.1 0.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.2 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.9 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.2 GO:0001771 immunological synapse formation(GO:0001771) optic nerve morphogenesis(GO:0021631)
0.0 0.3 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.4 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.5 GO:0042407 cristae formation(GO:0042407)
0.0 0.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.5 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.3 GO:0009303 rRNA transcription(GO:0009303)
0.0 1.1 GO:0019915 lipid storage(GO:0019915)
0.0 1.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0036337 Fas signaling pathway(GO:0036337)
0.0 0.7 GO:0021591 ventricular system development(GO:0021591)
0.0 0.0 GO:0061738 multivesicular body assembly(GO:0036258) late endosomal microautophagy(GO:0061738)
0.0 0.6 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 1.0 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.4 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0036156 inner dynein arm(GO:0036156)
0.4 1.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 1.4 GO:0070826 paraferritin complex(GO:0070826)
0.2 1.6 GO:0001740 Barr body(GO:0001740)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.2 2.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.6 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 1.5 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.4 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1 0.6 GO:0005638 lamin filament(GO:0005638)
0.1 0.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 1.6 GO:0002102 podosome(GO:0002102)
0.1 0.5 GO:0061617 MICOS complex(GO:0061617)
0.1 2.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 3.7 GO:0005581 collagen trimer(GO:0005581)
0.0 1.1 GO:0030673 axolemma(GO:0030673)
0.0 0.4 GO:0048188 MLL3/4 complex(GO:0044666) Set1C/COMPASS complex(GO:0048188)
0.0 1.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0070469 respiratory chain(GO:0070469)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.7 GO:0005871 kinesin complex(GO:0005871)
0.0 0.6 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.7 2.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.6 1.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.5 1.8 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.3 1.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 2.0 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.3 1.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.3 1.4 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 0.7 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.2 1.5 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.2 1.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 0.8 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.8 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.1 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 0.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.5 GO:0000182 rDNA binding(GO:0000182)
0.1 1.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.8 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.6 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 1.4 GO:0016415 octanoyltransferase activity(GO:0016415)
0.0 1.5 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 1.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.7 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.6 GO:0003774 motor activity(GO:0003774)
0.0 0.3 GO:0017134 fibroblast growth factor binding(GO:0017134)