Motif ID: Klf1

Z-value: 2.003


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_84901992-0.592.8e-04Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_46179929 10.384 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr11_+_104231390 9.637 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr7_+_44310213 9.502 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr8_+_84723003 9.230 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr6_+_103510874 9.192 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr11_+_104231515 8.363 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_+_104231465 8.053 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr10_+_106470281 8.001 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr10_-_81472859 7.912 ENSMUST00000147524.1
ENSMUST00000119060.1
 Celf5

CUGBP, Elav-like family member 5

chr6_+_5725639 7.319 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr15_+_83791939 7.230 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr10_-_81025521 7.141 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr8_+_93810832 6.570 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr11_-_69801716 6.502 ENSMUST00000011285.4
ENSMUST00000102585.1
 Fgf11

fibroblast growth factor 11

chr5_+_117781017 6.347 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr2_-_162661075 6.270 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr10_+_127078886 6.246 ENSMUST00000039259.6
 Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr5_-_139325616 6.196 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr17_+_3326552 5.877 ENSMUST00000169838.1
 Tiam2
T cell lymphoma invasion and metastasis 2
chr11_+_104231573 5.718 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 501 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 41.0 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.5 18.4 GO:0060074 synapse maturation(GO:0060074)
1.3 18.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 13.0 GO:0035640 exploration behavior(GO:0035640)
0.7 11.7 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
1.5 10.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
1.2 10.4 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.7 10.0 GO:0021540 corpus callosum morphogenesis(GO:0021540)
3.2 9.5 GO:0046959 habituation(GO:0046959)
0.3 9.5 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.1 8.9 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.3 8.5 GO:0010107 potassium ion import(GO:0010107)
0.1 8.5 GO:0007018 microtubule-based movement(GO:0007018)
0.1 8.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 7.8 GO:0009268 response to pH(GO:0009268)
0.9 7.3 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.4 7.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 6.9 GO:0001956 positive regulation of neurotransmitter secretion(GO:0001956)
0.3 6.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
2.2 6.6 GO:2000344 positive regulation of acrosome reaction(GO:2000344)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 190 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 35.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
2.8 27.8 GO:0045298 tubulin complex(GO:0045298)
0.1 26.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 20.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 13.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 13.1 GO:0008021 synaptic vesicle(GO:0008021)
0.7 12.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 12.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 12.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 11.9 GO:0005802 trans-Golgi network(GO:0005802)
0.2 11.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.6 11.0 GO:0044326 dendritic spine neck(GO:0044326)
0.1 10.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 8.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 8.1 GO:0048786 presynaptic active zone(GO:0048786)
1.3 7.5 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.3 7.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 7.3 GO:0035371 microtubule plus-end(GO:0035371)
0.2 7.2 GO:0005871 kinesin complex(GO:0005871)
0.4 7.1 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 332 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 28.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 27.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 20.1 GO:0003924 GTPase activity(GO:0003924)
0.1 18.3 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 15.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 13.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 13.1 GO:0019905 syntaxin binding(GO:0019905)
3.2 12.9 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
1.0 11.5 GO:0038191 neuropilin binding(GO:0038191)
0.8 10.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.5 10.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 10.0 GO:0003777 microtubule motor activity(GO:0003777)
0.5 9.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.5 9.6 GO:0050811 GABA receptor binding(GO:0050811)
0.2 8.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.5 8.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 8.1 GO:0003714 transcription corepressor activity(GO:0003714)
1.1 7.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.3 7.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 7.2 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)