Motif ID: Klf12_Klf14_Sp4

Z-value: 0.659

Transcription factors associated with Klf12_Klf14_Sp4:

Gene SymbolEntrez IDGene Name
Klf12 ENSMUSG00000072294.4 Klf12
Klf14 ENSMUSG00000073209.3 Klf14
Sp4 ENSMUSG00000025323.9 Sp4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp4mm10_v2_chr12_-_118301429_1183014580.271.2e-01Click!
Klf12mm10_v2_chr14_-_100149764_1001497640.222.3e-01Click!


Activity profile for motif Klf12_Klf14_Sp4.

activity profile for motif Klf12_Klf14_Sp4


Sorted Z-values histogram for motif Klf12_Klf14_Sp4

Sorted Z-values for motif Klf12_Klf14_Sp4



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf12_Klf14_Sp4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78322965 4.313 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr5_-_99252839 2.422 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr9_+_80165013 2.382 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr10_-_59951753 2.326 ENSMUST00000020308.3
 Ddit4
DNA-damage-inducible transcript 4
chr5_-_109558957 2.216 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr9_+_80165079 2.164 ENSMUST00000184480.1
 Myo6
myosin VI
chr2_-_30474199 2.010 ENSMUST00000065134.2
 Ier5l
immediate early response 5-like
chr2_+_172345565 1.837 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr5_+_37028329 1.774 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr13_+_92611119 1.742 ENSMUST00000049488.7
 Serinc5
serine incorporator 5
chr7_-_16273692 1.730 ENSMUST00000169612.1
 Prr24
proline rich 24
chr4_-_129121699 1.692 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
 Hpca


hippocalcin


chr5_+_33983437 1.597 ENSMUST00000114384.1
ENSMUST00000094869.5
ENSMUST00000114383.1
 Gm1673


predicted gene 1673


chr6_-_85374606 1.578 ENSMUST00000060837.7
 Rab11fip5
RAB11 family interacting protein 5 (class I)
chr4_-_120287349 1.568 ENSMUST00000102656.3
 Foxo6
forkhead box O6
chr2_-_134644079 1.451 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4
chr7_+_35802593 1.443 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr16_-_67620880 1.429 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr5_+_33983534 1.415 ENSMUST00000114382.1
 Gm1673
predicted gene 1673
chr11_-_53430779 1.395 ENSMUST00000061326.4
ENSMUST00000109021.3
 Uqcrq

ubiquinol-cytochrome c reductase, complex III subunit VII


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 442 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.1 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.4 4.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.3 4.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.5 2.6 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 2.5 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.2 2.3 GO:0045820 negative regulation of glycolytic process(GO:0045820)
0.4 2.1 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.1 2.1 GO:2000821 regulation of grooming behavior(GO:2000821)
0.0 2.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.8 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.4 1.7 GO:0009597 detection of virus(GO:0009597)
0.0 1.7 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.1 1.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.6 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.3 1.5 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 1.5 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.2 1.3 GO:1902669 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of axon guidance(GO:1902669)
0.2 1.3 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.1 1.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.5 GO:0044327 dendritic spine head(GO:0044327)
0.2 3.9 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 2.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.7 GO:0000786 nucleosome(GO:0000786)
0.3 2.3 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 2.1 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.7 GO:0032994 protein-lipid complex(GO:0032994)
0.4 1.6 GO:0045098 type III intermediate filament(GO:0045098)
0.0 1.6 GO:0055037 recycling endosome(GO:0055037)
0.1 1.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 1.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.3 GO:0070469 respiratory chain(GO:0070469)
0.1 1.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 1.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 1.1 GO:0070695 FHF complex(GO:0070695)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.0 GO:0042588 zymogen granule(GO:0042588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 286 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.7 4.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 3.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 3.3 GO:0005125 cytokine activity(GO:0005125)
0.0 3.3 GO:0051015 actin filament binding(GO:0051015)
0.1 3.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 2.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.6 1.8 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.3 1.8 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.8 GO:0031489 myosin V binding(GO:0031489)
0.0 1.8 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.2 1.7 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.0 1.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.2 1.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 1.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 1.3 GO:0036361 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)