Motif ID: Klf16_Sp8

Z-value: 1.110

Transcription factors associated with Klf16_Sp8:

Gene SymbolEntrez IDGene Name
Klf16 ENSMUSG00000035397.8 Klf16
Sp8 ENSMUSG00000048562.6 Sp8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf16mm10_v2_chr10_-_80577285_80577327-0.531.7e-03Click!
Sp8mm10_v2_chr12_+_118846329_1188463290.336.2e-02Click!


Activity profile for motif Klf16_Sp8.

activity profile for motif Klf16_Sp8


Sorted Z-values histogram for motif Klf16_Sp8

Sorted Z-values for motif Klf16_Sp8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf16_Sp8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_25622525 5.674 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr11_-_102946688 5.263 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr4_-_55532453 4.755 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)

chr7_-_38107490 4.650 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr19_+_53142756 4.432 ENSMUST00000050096.7
 Add3
adducin 3 (gamma)
chr12_+_103314944 4.075 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr7_+_107595051 3.921 ENSMUST00000040056.7
 Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr3_-_142395661 3.848 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
 Pdlim5



PDZ and LIM domain 5



chr7_-_4752972 3.787 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr10_-_88503952 3.655 ENSMUST00000020253.8
 Chpt1
choline phosphotransferase 1
chr17_-_32166879 3.642 ENSMUST00000087723.3
 Notch3
notch 3
chr18_+_49979514 3.603 ENSMUST00000179937.1
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr9_-_21798502 3.571 ENSMUST00000034717.5
 Kank2
KN motif and ankyrin repeat domains 2
chr1_-_64737735 3.549 ENSMUST00000063982.5
ENSMUST00000116133.2
 Fzd5

frizzled homolog 5 (Drosophila)

chr7_-_144939823 3.457 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr10_-_127341583 3.424 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr11_+_88718442 3.418 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr14_+_33923582 3.384 ENSMUST00000168727.1
 Gdf10
growth differentiation factor 10
chr17_-_70851189 3.382 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr11_+_3488275 3.362 ENSMUST00000064265.6
 Pla2g3
phospholipase A2, group III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,166 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.4 GO:0034605 cellular response to heat(GO:0034605)
1.5 9.0 GO:0042160 lipoprotein modification(GO:0042160) lipoprotein oxidation(GO:0042161)
0.7 8.9 GO:0044458 motile cilium assembly(GO:0044458)
0.3 8.8 GO:0006270 DNA replication initiation(GO:0006270)
0.3 8.5 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
1.9 7.7 GO:0046469 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.4 7.7 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.3 7.5 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 7.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 7.4 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.2 7.3 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.4 6.9 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
1.3 6.7 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.8 6.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 6.6 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.2 6.6 GO:0070206 protein trimerization(GO:0070206)
0.4 6.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.4 6.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.2 5.6 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
1.4 5.5 GO:0015888 thiamine transport(GO:0015888)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 400 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 73.2 GO:0005615 extracellular space(GO:0005615)
0.1 51.9 GO:0005667 transcription factor complex(GO:0005667)
0.3 19.4 GO:0005581 collagen trimer(GO:0005581)
0.4 16.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 15.9 GO:0070062 extracellular exosome(GO:0070062)
0.1 12.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 11.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 10.6 GO:0000791 euchromatin(GO:0000791)
0.2 9.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.7 8.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 8.4 GO:0030055 cell-substrate junction(GO:0030055)
0.1 8.3 GO:0005844 polysome(GO:0005844)
0.1 7.5 GO:0005876 spindle microtubule(GO:0005876)
0.1 7.5 GO:0031526 brush border membrane(GO:0031526)
0.1 7.5 GO:0005902 microvillus(GO:0005902)
0.3 7.2 GO:0005605 basal lamina(GO:0005605)
0.1 6.4 GO:0005811 lipid particle(GO:0005811)
0.6 6.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 6.2 GO:0032432 actin filament bundle(GO:0032432)
0.5 6.1 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 645 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 35.8 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
0.2 13.3 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.3 11.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 11.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 11.0 GO:0005179 hormone activity(GO:0005179)
0.5 10.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 9.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 9.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 8.5 GO:0017166 vinculin binding(GO:0017166)
0.3 7.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
1.4 7.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.2 7.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.8 7.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.8 6.8 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.5 6.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.7 6.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 6.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.3 6.5 GO:0032027 myosin light chain binding(GO:0032027)
0.2 6.5 GO:0005109 frizzled binding(GO:0005109)
0.0 6.3 GO:0003735 structural constituent of ribosome(GO:0003735)