Motif ID: Klf4_Sp3

Z-value: 1.999

Transcription factors associated with Klf4_Sp3:

Gene SymbolEntrez IDGene Name
Klf4 ENSMUSG00000003032.8 Klf4
Sp3 ENSMUSG00000027109.10 Sp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp3mm10_v2_chr2_-_72980402_72980471-0.873.1e-11Click!
Klf4mm10_v2_chr4_-_55532453_55532485-0.202.6e-01Click!


Activity profile for motif Klf4_Sp3.

activity profile for motif Klf4_Sp3


Sorted Z-values histogram for motif Klf4_Sp3

Sorted Z-values for motif Klf4_Sp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf4_Sp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_105518736 19.022 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr12_+_17690793 15.394 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr7_-_38107490 14.313 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr7_-_143460989 14.307 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_+_124986430 13.693 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr4_-_117133953 13.536 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr7_+_29289300 13.155 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chrX_+_73639414 12.865 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr5_-_144358103 12.845 ENSMUST00000055190.7
 Baiap2l1
BAI1-associated protein 2-like 1
chr8_+_87473116 12.632 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr19_-_45742873 11.931 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chrX_-_106485214 11.858 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr2_-_92370999 11.765 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr2_-_92370968 11.454 ENSMUST00000176774.1
 Gyltl1b
glycosyltransferase-like 1B
chr17_-_70851189 11.366 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr11_+_32276893 11.167 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr4_-_129239165 10.944 ENSMUST00000097873.3
 C77080
expressed sequence C77080
chr2_-_92371039 10.842 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B
chr4_-_107253513 10.771 ENSMUST00000030360.4
 Lrrc42
leucine rich repeat containing 42
chr17_+_57249450 10.475 ENSMUST00000019631.9
 Trip10
thyroid hormone receptor interactor 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,175 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 37.6 GO:0006412 translation(GO:0006412)
1.7 34.8 GO:0038092 nodal signaling pathway(GO:0038092)
0.3 33.0 GO:0042254 ribosome biogenesis(GO:0042254)
2.4 32.9 GO:0035269 protein O-linked mannosylation(GO:0035269)
2.2 31.2 GO:0051764 actin crosslink formation(GO:0051764)
0.9 31.2 GO:0006270 DNA replication initiation(GO:0006270)
1.0 27.1 GO:0006783 heme biosynthetic process(GO:0006783)
5.3 26.7 GO:0015671 oxygen transport(GO:0015671)
0.7 23.7 GO:0006101 citrate metabolic process(GO:0006101)
0.7 21.4 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.3 20.6 GO:0008033 tRNA processing(GO:0008033)
1.3 20.2 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
1.1 20.2 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.9 19.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
4.9 19.5 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
2.4 19.2 GO:0008343 adult feeding behavior(GO:0008343)
0.9 19.2 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
1.1 18.6 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
3.7 18.5 GO:0006177 GMP biosynthetic process(GO:0006177)
1.1 18.2 GO:0060065 uterus development(GO:0060065)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 425 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 106.7 GO:0005634 nucleus(GO:0005634)
0.1 93.9 GO:0005829 cytosol(GO:0005829)
0.1 49.0 GO:0005730 nucleolus(GO:0005730)
0.2 47.2 GO:0005667 transcription factor complex(GO:0005667)
0.6 45.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 44.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.9 40.5 GO:0008180 COP9 signalosome(GO:0008180)
0.4 40.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 38.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.6 37.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.8 35.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
3.9 30.9 GO:0005833 hemoglobin complex(GO:0005833)
0.7 30.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.1 25.9 GO:0030914 STAGA complex(GO:0030914)
0.3 21.2 GO:0017053 transcriptional repressor complex(GO:0017053)
1.7 20.7 GO:0030057 desmosome(GO:0030057)
0.4 20.4 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
3.2 19.4 GO:0061689 tricellular tight junction(GO:0061689)
1.4 19.1 GO:0035686 sperm fibrous sheath(GO:0035686)
1.2 19.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 651 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 125.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 74.6 GO:0044822 poly(A) RNA binding(GO:0044822)
0.6 38.0 GO:0002039 p53 binding(GO:0002039)
0.5 37.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.7 34.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
6.7 33.7 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.9 31.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.5 31.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.9 29.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 27.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
5.3 26.7 GO:0005344 oxygen transporter activity(GO:0005344)
1.2 25.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.5 24.7 GO:0003743 translation initiation factor activity(GO:0003743)
1.7 24.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
1.1 24.1 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
1.0 22.5 GO:0070410 co-SMAD binding(GO:0070410)
0.3 22.3 GO:0003697 single-stranded DNA binding(GO:0003697)
1.7 22.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.5 22.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 21.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)