Motif ID: Klf8

Z-value: 0.736


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153359613_153359613-0.881.2e-11Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 7.344 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr6_-_72788952 3.723 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr3_+_87948666 3.195 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr7_-_144939823 3.052 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr19_+_25610533 2.708 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr7_-_127026479 2.561 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr4_+_46450892 2.466 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr7_-_142657466 2.327 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr18_+_74442500 2.255 ENSMUST00000074157.6
 Myo5b
myosin VB
chr11_+_85832551 2.209 ENSMUST00000000095.6
 Tbx2
T-box 2
chr9_-_8004585 2.197 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr6_+_34354119 2.143 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr12_+_109452833 2.025 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr3_-_89393294 1.739 ENSMUST00000142119.1
ENSMUST00000029677.8
ENSMUST00000148361.1
 Zbtb7b


zinc finger and BTB domain containing 7B


chr16_+_30599717 1.709 ENSMUST00000059078.3
 Fam43a
family with sequence similarity 43, member A
chrX_-_7967817 1.674 ENSMUST00000033502.7
 Gata1
GATA binding protein 1
chr19_-_10240689 1.563 ENSMUST00000088013.5
 Myrf
myelin regulatory factor
chr3_+_146500071 1.503 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr15_+_39006272 1.473 ENSMUST00000179165.1
ENSMUST00000022906.7
 Fzd6

frizzled homolog 6 (Drosophila)

chr2_+_27886416 1.456 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 4.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.4 3.9 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
1.2 3.7 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.4 3.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 2.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.5 2.6 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.5 2.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 2.6 GO:0009299 mRNA transcription(GO:0009299)
0.1 2.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.8 2.3 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.6 2.3 GO:0032439 endosome localization(GO:0032439)
0.3 2.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.3 2.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.7 2.2 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.4 2.2 GO:0060242 contact inhibition(GO:0060242)
0.7 2.1 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.7 2.0 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.5 2.0 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.4 2.0 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.0 GO:0009897 external side of plasma membrane(GO:0009897)
1.3 3.9 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 2.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 2.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 2.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.8 GO:0031526 brush border membrane(GO:0031526)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.5 1.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.4 GO:0031415 NatA complex(GO:0031415)
0.1 1.4 GO:0042555 MCM complex(GO:0042555)
0.4 1.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 1.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.3 1.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 1.1 GO:0061689 tricellular tight junction(GO:0061689)
0.2 1.1 GO:0045179 apical cortex(GO:0045179)
0.1 1.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.7 GO:0070410 co-SMAD binding(GO:0070410)
0.0 5.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 5.2 GO:0070064 proline-rich region binding(GO:0070064)
0.1 4.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.5 3.2 GO:0019841 retinol binding(GO:0019841)
0.0 3.2 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 2.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.8 GO:0001948 glycoprotein binding(GO:0001948)
0.2 2.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.3 2.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 2.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.7 2.2 GO:0005118 sevenless binding(GO:0005118)
0.4 2.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 2.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 1.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.5 1.4 GO:0017089 glycolipid transporter activity(GO:0017089)