Motif ID: Lef1

Z-value: 1.149


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131112785_131112803-0.115.3e-01Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_23038656 5.480 ENSMUST00000081423.6
 Nol4
nucleolar protein 4
chrX_-_143933204 5.237 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr4_-_91376433 4.828 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chrX_-_143933089 4.756 ENSMUST00000087313.3
 Dcx
doublecortin
chr4_-_91376490 4.605 ENSMUST00000107124.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr2_+_73271925 4.536 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr2_+_152081529 4.494 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr8_-_84773381 4.281 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr2_-_156312470 4.036 ENSMUST00000079125.6
 Scand1
SCAN domain-containing 1
chr2_+_61804453 4.010 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr18_-_43059418 3.997 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr16_+_20097554 3.889 ENSMUST00000023509.3
 Klhl24
kelch-like 24
chr4_+_97777780 3.109 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
 Nfia


nuclear factor I/A


chr1_+_136131382 3.072 ENSMUST00000075164.4
 Kif21b
kinesin family member 21B
chr4_-_82705735 2.983 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr8_+_45507768 2.975 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chr9_-_49798905 2.836 ENSMUST00000114476.2
 Ncam1
neural cell adhesion molecule 1
chr12_+_29528382 2.780 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr3_-_116968969 2.769 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr5_+_17574726 2.719 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 11.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.8 7.2 GO:0071420 cellular response to histamine(GO:0071420)
1.8 5.5 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 4.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 4.5 GO:0045760 positive regulation of action potential(GO:0045760)
0.1 4.5 GO:0071242 cellular response to ammonium ion(GO:0071242)
0.3 4.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 4.0 GO:0021764 amygdala development(GO:0021764)
0.8 4.0 GO:0046684 response to pyrethroid(GO:0046684)
0.6 4.0 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.1 4.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.9 3.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 3.8 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 3.8 GO:0008360 regulation of cell shape(GO:0008360)
0.1 3.6 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601) regulation of glutamate receptor signaling pathway(GO:1900449)
0.1 3.4 GO:0060074 synapse maturation(GO:0060074)
0.0 3.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.7 3.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 3.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 2.9 GO:0001967 suckling behavior(GO:0001967)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.5 GO:0030425 dendrite(GO:0030425)
0.4 7.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 5.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 4.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 4.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.3 3.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 3.8 GO:0043205 fibril(GO:0043205)
0.3 3.5 GO:0097449 astrocyte projection(GO:0097449)
0.1 3.5 GO:0043194 axon initial segment(GO:0043194)
0.1 3.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 3.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 3.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 3.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 3.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.6 GO:0030315 T-tubule(GO:0030315)
0.0 2.6 GO:0016363 nuclear matrix(GO:0016363)
0.6 2.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.5 2.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 2.2 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 7.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 6.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 6.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 5.5 GO:0030275 LRR domain binding(GO:0030275)
0.2 4.4 GO:0031402 sodium ion binding(GO:0031402)
0.3 4.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 3.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.8 3.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 3.6 GO:0044325 ion channel binding(GO:0044325)
0.1 3.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.9 2.8 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.2 2.7 GO:0038191 neuropilin binding(GO:0038191)
0.2 2.5 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 2.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.4 GO:0030552 cAMP binding(GO:0030552)
0.6 2.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 2.3 GO:0030332 cyclin binding(GO:0030332)
0.2 2.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 2.2 GO:0017075 syntaxin-1 binding(GO:0017075)