Motif ID: Lhx2_Hoxc5

Z-value: 0.465

Transcription factors associated with Lhx2_Hoxc5:

Gene SymbolEntrez IDGene Name
Hoxc5 ENSMUSG00000022485.3 Hoxc5
Lhx2 ENSMUSG00000000247.5 Lhx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx2mm10_v2_chr2_+_38341068_38341092-0.261.4e-01Click!


Activity profile for motif Lhx2_Hoxc5.

activity profile for motif Lhx2_Hoxc5


Sorted Z-values histogram for motif Lhx2_Hoxc5

Sorted Z-values for motif Lhx2_Hoxc5



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx2_Hoxc5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_146121655 2.469 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr10_-_77166545 2.027 ENSMUST00000081654.6
 Col18a1
collagen, type XVIII, alpha 1
chr5_-_138170992 1.813 ENSMUST00000139983.1
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr2_-_168767136 1.657 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr17_-_48432723 1.412 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr2_-_168767029 1.391 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr1_+_24177610 1.390 ENSMUST00000054588.8
 Col9a1
collagen, type IX, alpha 1
chr2_-_155074447 1.388 ENSMUST00000137242.1
ENSMUST00000054607.9
 Ahcy

S-adenosylhomocysteine hydrolase

chr2_+_109917639 1.327 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr9_+_119063429 1.287 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr13_-_81710937 1.205 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr4_+_3938888 1.144 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr9_+_53771499 1.074 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr11_-_102365111 1.023 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr9_+_72806874 0.937 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr11_+_32283511 0.911 ENSMUST00000093209.3
 Hba-a1
hemoglobin alpha, adult chain 1
chr18_+_74442551 0.909 ENSMUST00000121875.1
 Myo5b
myosin VB
chr14_+_69347587 0.875 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr13_+_44121167 0.835 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chrM_+_8600 0.814 ENSMUST00000082409.1
 mt-Co3
mitochondrially encoded cytochrome c oxidase III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 2.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 2.1 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 1.7 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.5 GO:0080111 DNA demethylation(GO:0080111)
0.0 1.5 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.2 1.4 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.4 GO:0003417 growth plate cartilage development(GO:0003417)
0.4 1.3 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 1.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.3 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.2 1.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.4 1.1 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.0 1.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 1.0 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 1.0 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.0 GO:0051693 actin filament capping(GO:0051693)
0.0 1.0 GO:0006414 translational elongation(GO:0006414)
0.3 0.9 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.2 0.9 GO:0032439 endosome localization(GO:0032439)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0005604 basement membrane(GO:0005604)
0.2 2.6 GO:0042555 MCM complex(GO:0042555)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.2 GO:0000792 heterochromatin(GO:0000792)
0.0 1.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 1.4 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 1.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 0.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 0.9 GO:0045179 apical cortex(GO:0045179)
0.1 0.9 GO:0001739 sex chromatin(GO:0001739)
0.1 0.9 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.9 GO:0042611 MHC protein complex(GO:0042611)
0.1 0.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.8 GO:0071564 npBAF complex(GO:0071564)
0.1 0.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.7 GO:0000800 lateral element(GO:0000800)
0.0 0.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 1.6 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 1.6 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 1.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.4 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 1.3 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.1 1.2 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.2 GO:0000049 tRNA binding(GO:0000049)
0.0 1.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.2 0.9 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.9 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.8 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)