Motif ID: Lhx3

Z-value: 0.753


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_136143497 7.271 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr3_+_122419772 4.856 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr14_-_48665098 4.507 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr7_-_45103747 3.729 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr2_-_84425258 3.460 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr13_+_49608030 2.877 ENSMUST00000021822.5
 Ogn
osteoglycin
chr12_-_56536895 2.770 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr11_+_59306920 2.283 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr5_-_70842617 2.252 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr19_+_20601958 2.095 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr11_+_109543694 2.083 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr5_-_62766153 2.079 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_75037291 1.982 ENSMUST00000139384.1
 Rab36
RAB36, member RAS oncogene family
chr10_+_75037066 1.748 ENSMUST00000147802.1
ENSMUST00000020391.5
 Rab36

RAB36, member RAS oncogene family

chr3_-_67515487 1.687 ENSMUST00000178314.1
ENSMUST00000054825.4
 Rarres1

retinoic acid receptor responder (tazarotene induced) 1

chr5_-_62765618 1.669 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_51553896 1.597 ENSMUST00000132734.1
 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr7_-_103827922 1.553 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr4_+_102589687 1.531 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr10_-_64090265 1.514 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr17_-_67950908 1.423 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr10_-_53647080 1.361 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chrX_-_139871637 1.317 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4

chr10_-_64090241 1.249 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_37138863 1.027 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr14_+_69347587 1.024 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr3_+_66985680 0.986 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr3_-_57294880 0.861 ENSMUST00000171384.1
 Tm4sf1
transmembrane 4 superfamily member 1
chr3_+_66985647 0.856 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chrX_+_66653003 0.854 ENSMUST00000036043.4
 Slitrk2
SLIT and NTRK-like family, member 2
chr18_+_57468478 0.777 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr11_-_89639631 0.763 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr3_+_151437887 0.730 ENSMUST00000046977.7
 Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr11_-_30198232 0.688 ENSMUST00000102838.3
 Sptbn1
spectrin beta, non-erythrocytic 1
chr3_-_116712644 0.686 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr8_-_21906412 0.629 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr7_-_37772868 0.594 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr3_+_84952146 0.576 ENSMUST00000029727.7
 Fbxw7
F-box and WD-40 domain protein 7
chr6_+_34780412 0.568 ENSMUST00000115016.1
ENSMUST00000115017.1
 Agbl3

ATP/GTP binding protein-like 3

chr17_-_78684262 0.554 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr3_+_53845086 0.539 ENSMUST00000108014.1
 Gm10985
predicted gene 10985
chrX_+_100625737 0.434 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chrX_-_94123087 0.432 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr3_+_95318782 0.430 ENSMUST00000139866.1
 Cers2
ceramide synthase 2
chr4_-_14621805 0.403 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr13_-_101692624 0.400 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr4_+_147492417 0.380 ENSMUST00000105721.2
 Gm13152
predicted gene 13152
chr10_-_62507737 0.352 ENSMUST00000020271.6
 Srgn
serglycin
chr9_+_96258697 0.323 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr9_+_120929216 0.321 ENSMUST00000130466.1
 Ctnnb1
catenin (cadherin associated protein), beta 1
chr2_-_33087169 0.308 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_3114220 0.300 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr4_+_134930898 0.293 ENSMUST00000030622.2
 Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr2_-_33086366 0.280 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr13_-_58354862 0.269 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr3_+_142620596 0.251 ENSMUST00000165774.1
 Gbp2
guanylate binding protein 2
chr4_-_14621669 0.215 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr4_+_118961578 0.199 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr3_+_41742615 0.191 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr17_-_56036546 0.190 ENSMUST00000003268.9
 Sh3gl1
SH3-domain GRB2-like 1
chr2_+_36230426 0.178 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr4_+_147132038 0.153 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chrX_+_166344692 0.147 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr10_-_35711891 0.135 ENSMUST00000080898.2
 Amd2
S-adenosylmethionine decarboxylase 2
chr5_+_96209463 0.131 ENSMUST00000117766.1
 Mrpl1
mitochondrial ribosomal protein L1
chr2_+_163658370 0.114 ENSMUST00000164399.1
ENSMUST00000064703.6
ENSMUST00000099105.2
ENSMUST00000152418.1
ENSMUST00000126182.1
ENSMUST00000131228.1
 Pkig





protein kinase inhibitor, gamma





chr19_+_46397009 0.108 ENSMUST00000118440.1
 Sufu
suppressor of fused homolog (Drosophila)
chr4_-_58499398 0.102 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr13_-_74482943 0.091 ENSMUST00000074369.6
 Zfp825
zinc finger protein 825
chr5_+_96210115 0.090 ENSMUST00000036437.6
ENSMUST00000121477.1
 Mrpl1

mitochondrial ribosomal protein L1

chr10_+_23797052 0.076 ENSMUST00000133289.1
 Slc18b1
solute carrier family 18, subfamily B, member 1
chrM_+_9452 0.073 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr4_-_147809788 0.066 ENSMUST00000105734.3
ENSMUST00000176201.1
 Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr17_+_45734506 0.059 ENSMUST00000180558.1
 F630040K05Rik
RIKEN cDNA F630040K05 gene
chr10_+_116143881 0.050 ENSMUST00000105271.2
 Ptprr
protein tyrosine phosphatase, receptor type, R
chr4_+_146610961 0.032 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chr6_+_37870786 0.022 ENSMUST00000120428.1
ENSMUST00000031859.7
 Trim24

tripartite motif-containing 24


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.9 2.8 GO:0021759 globus pallidus development(GO:0021759)
0.9 3.5 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.5 1.6 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.5 2.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.4 1.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.3 1.0 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.3 7.3 GO:0071398 cellular response to fatty acid(GO:0071398)
0.2 2.8 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.1 5.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.6 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.4 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.1 0.7 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 1.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.4 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.8 GO:0050957 equilibrioception(GO:0050957)
0.1 2.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.6 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.7 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.6 GO:0019532 oxalate transport(GO:0019532)
0.1 2.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.4 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1 0.2 GO:0035633 negative regulation of epinephrine secretion(GO:0032811) maintenance of blood-brain barrier(GO:0035633)
0.1 1.8 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.4 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 3.0 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.4 GO:0060746 parental behavior(GO:0060746)
0.0 0.1 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.3 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.3 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 1.0 GO:0042585 germinal vesicle(GO:0042585)
0.2 0.7 GO:0032437 cuticular plate(GO:0032437)
0.1 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 2.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 1.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.3 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 4.0 GO:0030426 growth cone(GO:0030426)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.0 0.7 GO:0005871 kinesin complex(GO:0005871)
0.0 5.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0019770 IgG receptor activity(GO:0019770)
0.9 3.5 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.4 1.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.3 2.1 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 2.1 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.2 2.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 7.4 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.0 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 2.3 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.1 0.6 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.4 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 3.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 2.3 GO:0005109 frizzled binding(GO:0005109)
0.1 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.3 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.5 GO:0030552 cAMP binding(GO:0030552)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 2.9 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.9 GO:0008083 growth factor activity(GO:0008083)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 4.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 4.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 4.0 GO:0005525 GTP binding(GO:0005525)