Motif ID: Lhx4

Z-value: 0.929


Transcription factors associated with Lhx4:

Gene SymbolEntrez IDGene Name
Lhx4 ENSMUSG00000026468.8 Lhx4



Activity profile for motif Lhx4.

activity profile for motif Lhx4


Sorted Z-values histogram for motif Lhx4

Sorted Z-values for motif Lhx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 190 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 11.040 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr19_+_44493472 7.117 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr4_+_136143497 6.821 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr7_-_49636847 6.764 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr3_+_122419772 5.276 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr11_+_59306920 4.792 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr5_-_62765618 4.446 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_+_72806874 4.000 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr2_-_166155272 3.814 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr7_-_37773555 3.626 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr15_-_56694525 3.567 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr1_-_163289214 3.489 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr2_-_166155624 3.400 ENSMUST00000109249.2
 Sulf2
sulfatase 2
chr4_+_65124174 3.068 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr2_-_28916412 2.708 ENSMUST00000050776.2
ENSMUST00000113849.1
 Barhl1

BarH-like 1 (Drosophila)

chr7_-_45103747 2.701 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr15_-_103215285 2.664 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr12_-_73047179 2.660 ENSMUST00000050029.7
 Six1
sine oculis-related homeobox 1
chr5_-_62766153 2.520 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_+_34592248 2.493 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 11.0 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 8.1 GO:0016055 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
0.5 7.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.8 7.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 7.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 6.8 GO:0071398 cellular response to fatty acid(GO:0071398)
0.5 6.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.6 4.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 4.8 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 4.8 GO:0007605 sensory perception of sound(GO:0007605)
0.2 4.4 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 4.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.9 3.6 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 3.5 GO:0048664 neuron fate determination(GO:0048664)
0.8 3.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 3.1 GO:0051384 response to glucocorticoid(GO:0051384)
0.9 2.7 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1 2.6 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 2.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 2.5 GO:0042541 hemoglobin biosynthetic process(GO:0042541)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 6.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 6.0 GO:0030426 growth cone(GO:0030426)
0.2 3.3 GO:0043205 fibril(GO:0043205)
0.0 2.9 GO:0009925 basal plasma membrane(GO:0009925)
0.1 2.7 GO:0010369 chromocenter(GO:0010369)
0.0 2.6 GO:0000776 kinetochore(GO:0000776)
0.0 2.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.7 2.2 GO:0042585 germinal vesicle(GO:0042585)
0.7 2.2 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 2.2 GO:0005884 actin filament(GO:0005884)
0.3 2.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.1 2.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.9 GO:0072372 primary cilium(GO:0072372)
0.2 1.7 GO:0031091 platelet alpha granule(GO:0031091)
0.1 1.7 GO:0002102 podosome(GO:0002102)
0.0 1.7 GO:0016459 myosin complex(GO:0016459)
0.0 1.5 GO:0005902 microvillus(GO:0005902)
0.0 1.5 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.9 GO:0005109 frizzled binding(GO:0005109)
1.4 7.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 7.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 7.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 6.9 GO:0005504 fatty acid binding(GO:0005504)
0.0 6.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 5.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.7 4.9 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 4.9 GO:0071837 HMG box domain binding(GO:0071837)
1.2 3.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 3.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.7 3.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 3.2 GO:0000287 magnesium ion binding(GO:0000287)
0.0 3.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.9 2.7 GO:0019770 IgG receptor activity(GO:0019770)
0.0 2.7 GO:0035064 methylated histone binding(GO:0035064)
0.4 2.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 2.5 GO:0016594 glycine binding(GO:0016594)
0.3 2.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.4 2.2 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)