Motif ID: Lhx8

Z-value: 0.562


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.193.0e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_137553517 1.520 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr3_-_73056943 1.448 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr8_+_34054622 1.382 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr5_-_139129662 1.331 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr1_-_44218952 1.320 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E
chr8_+_104831572 1.312 ENSMUST00000059449.6
 Ces2b
carboxyesterase 2B
chr7_+_91090697 1.305 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 1.291 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr1_+_72284367 1.276 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr2_-_52558539 1.268 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr2_+_65620829 1.181 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr13_-_62466709 1.136 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chr18_+_23415400 1.130 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr6_-_136173492 1.092 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr13_+_62129894 1.047 ENSMUST00000099449.3
 Zfp808
zinc finger protein 80
chr13_-_66851513 1.042 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr19_+_11469353 1.018 ENSMUST00000165310.1
 Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C
chr15_+_21111452 1.004 ENSMUST00000075132.6
 Cdh12
cadherin 12
chrX_+_101640056 0.975 ENSMUST00000119299.1
ENSMUST00000044475.4
 Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr4_-_129121889 0.875 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr6_+_15185203 0.864 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr2_-_45110336 0.782 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr14_-_46831984 0.688 ENSMUST00000181311.1
ENSMUST00000074862.2
 Gm10101

predicted gene 10101

chr14_+_54625305 0.634 ENSMUST00000097177.4
 Psmb11
proteasome (prosome, macropain) subunit, beta type, 11
chr15_-_99820072 0.597 ENSMUST00000109024.2
 Lima1
LIM domain and actin binding 1
chr1_+_33908172 0.596 ENSMUST00000182513.1
ENSMUST00000183034.1
 Dst

dystonin

chr17_-_21908092 0.582 ENSMUST00000106026.2
 2210404O09Rik
RIKEN cDNA 2210404O09 gene
chr4_-_155645408 0.581 ENSMUST00000115821.2
 Gm10563
predicted gene 10563
chr8_+_110079758 0.577 ENSMUST00000058804.8
 Zfp612
zinc finger protein 612
chr5_-_76905390 0.569 ENSMUST00000135954.1
 Aasdh
aminoadipate-semialdehyde dehydrogenase
chr1_+_17145357 0.569 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chrX_-_157415286 0.492 ENSMUST00000079945.4
ENSMUST00000138396.1
 Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr2_-_67433181 0.491 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr2_+_177508570 0.484 ENSMUST00000108940.2
 Gm14403
predicted gene 14403
chr18_-_43687695 0.470 ENSMUST00000082254.6
 Jakmip2
janus kinase and microtubule interacting protein 2
chr17_-_90088343 0.463 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr5_-_76905463 0.457 ENSMUST00000146570.1
ENSMUST00000142450.1
ENSMUST00000120963.1
 Aasdh


aminoadipate-semialdehyde dehydrogenase


chr2_-_114013619 0.452 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr11_+_110968016 0.423 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr10_-_4432285 0.411 ENSMUST00000155172.1
 Rmnd1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr10_+_58497918 0.392 ENSMUST00000036576.8
 Ccdc138
coiled-coil domain containing 138
chr3_-_116712644 0.389 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr12_+_38783455 0.383 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr18_+_37341702 0.375 ENSMUST00000053037.3
 Pcdhb7
protocadherin beta 7
chr8_-_69373383 0.364 ENSMUST00000072427.4
 Gm10033
predicted gene 10033
chr3_+_76075583 0.354 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr3_+_107291215 0.350 ENSMUST00000029502.7
 Slc16a4
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr10_-_4432312 0.329 ENSMUST00000126102.1
ENSMUST00000131853.1
ENSMUST00000042251.4
 Rmnd1


required for meiotic nuclear division 1 homolog (S. cerevisiae)


chr2_-_175131864 0.320 ENSMUST00000108929.2
 Gm14399
predicted gene 14399
chr16_+_24721842 0.303 ENSMUST00000115314.2
 Lpp
LIM domain containing preferred translocation partner in lipoma
chr12_+_38783503 0.302 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr15_-_98221056 0.291 ENSMUST00000170618.1
ENSMUST00000141911.1
 Olfr287

olfactory receptor 287

chr17_-_24632608 0.287 ENSMUST00000097373.1
 Tsc2
tuberous sclerosis 2
chr1_-_74588117 0.261 ENSMUST00000066986.6
 Zfp142
zinc finger protein 142
chr5_+_25759987 0.259 ENSMUST00000128727.1
ENSMUST00000088244.4
 Actr3b

ARP3 actin-related protein 3B

chr3_-_144760841 0.256 ENSMUST00000059091.5
 Clca1
chloride channel calcium activated 1
chr6_+_11926758 0.243 ENSMUST00000133776.1
 Phf14
PHD finger protein 14
chr13_+_65512678 0.228 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr1_-_170867761 0.226 ENSMUST00000027974.6
 Atf6
activating transcription factor 6
chr18_+_12972225 0.224 ENSMUST00000025290.5
 Impact
imprinted and ancient
chr4_+_126556994 0.218 ENSMUST00000147675.1
 Clspn
claspin
chr4_-_96591555 0.209 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr5_+_123930675 0.207 ENSMUST00000094320.3
ENSMUST00000165148.1
 Ccdc62

coiled-coil domain containing 62

chr13_-_66227573 0.191 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr11_+_16257706 0.186 ENSMUST00000109645.2
ENSMUST00000109647.2
 Vstm2a

V-set and transmembrane domain containing 2A

chr1_+_6487231 0.177 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr7_-_28372597 0.164 ENSMUST00000144700.1
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr3_-_100685431 0.156 ENSMUST00000008907.7
 Man1a2
mannosidase, alpha, class 1A, member 2
chr8_+_72219726 0.150 ENSMUST00000003123.8
 Fam32a
family with sequence similarity 32, member A
chr12_-_20900867 0.146 ENSMUST00000079237.5
 Zfp125
zinc finger protein 125
chr7_+_19359740 0.139 ENSMUST00000140836.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr13_-_66852017 0.136 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr13_+_5861489 0.135 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr2_-_72986716 0.130 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr8_-_41054771 0.126 ENSMUST00000093534.4
 Mtus1
mitochondrial tumor suppressor 1
chr2_+_112284561 0.092 ENSMUST00000053666.7
 Slc12a6
solute carrier family 12, member 6
chr3_-_53017195 0.086 ENSMUST00000036665.4
 Cog6
component of oligomeric golgi complex 6
chr7_-_28372233 0.074 ENSMUST00000094644.4
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr3_+_121953213 0.071 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr15_+_78935177 0.066 ENSMUST00000145157.1
ENSMUST00000123013.1
 Nol12

nucleolar protein 12

chr11_+_32226481 0.065 ENSMUST00000020528.7
 Mpg
N-methylpurine-DNA glycosylase
chr17_-_31519914 0.054 ENSMUST00000167419.1
ENSMUST00000171291.1
 Wdr4

WD repeat domain 4

chr4_+_126556935 0.051 ENSMUST00000048391.8
 Clspn
claspin
chr7_-_28372494 0.041 ENSMUST00000119990.1
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr5_-_62765618 0.029 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_73312601 0.026 ENSMUST00000090811.4
ENSMUST00000112050.1
 Scrn3

secernin 3

chr7_+_27553244 0.012 ENSMUST00000067386.7
 2310022A10Rik
RIKEN cDNA 2310022A10 gene
chr3_-_116712696 0.008 ENSMUST00000169530.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr6_+_47920476 0.004 ENSMUST00000009411.8
 Zfp212
Zinc finger protein 212
chr8_+_45627709 0.000 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 1.0 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.3 1.2 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.3 0.9 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.2 2.6 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.2 1.3 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.8 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.2 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 0.4 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.2 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.1 0.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.3 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 1.1 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 0.7 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.6 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0071476 hypotonic response(GO:0006971) cellular hypotonic response(GO:0071476)
0.0 0.3 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.6 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.2 GO:0071392 cellular response to estradiol stimulus(GO:0071392)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0031673 H zone(GO:0031673)
0.1 2.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.0 GO:0070688 MLL5-L complex(GO:0070688)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.9 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.3 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 1.5 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 1.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.6 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 1.0 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.1 2.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 1.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.3 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 1.3 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0004364 glutathione transferase activity(GO:0004364)