Motif ID: Maff

Z-value: 0.496


Transcription factors associated with Maff:

Gene SymbolEntrez IDGene Name
Maff ENSMUSG00000042622.7 Maff

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maffmm10_v2_chr15_+_79347534_793475560.411.8e-02Click!


Activity profile for motif Maff.

activity profile for motif Maff


Sorted Z-values histogram for motif Maff

Sorted Z-values for motif Maff



Network of associatons between targets according to the STRING database.



First level regulatory network of Maff

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_118787894 3.462 ENSMUST00000047761.6
ENSMUST00000071546.7
 Cldn10

claudin 10

chr15_+_3270767 2.933 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr6_+_120773633 2.148 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr17_-_25570678 2.001 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr13_-_23710714 1.976 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr16_-_22439719 1.678 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr19_+_56722372 1.452 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr17_+_86963279 1.371 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr11_-_109473598 1.223 ENSMUST00000070152.5
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr1_-_120074023 1.155 ENSMUST00000056089.7
 Tmem37
transmembrane protein 37
chr7_+_84528964 1.140 ENSMUST00000180387.1
 Gm2115
predicted gene 2115
chr18_+_4921662 1.138 ENSMUST00000143254.1
 Svil
supervillin
chr4_-_136886187 1.110 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr1_+_136018062 1.008 ENSMUST00000117950.1
 Tmem9
transmembrane protein 9
chr5_+_104435112 1.008 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr1_+_136017967 0.995 ENSMUST00000063719.8
ENSMUST00000118832.1
 Tmem9

transmembrane protein 9

chr4_+_102421518 0.946 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_-_143299498 0.910 ENSMUST00000030317.7
 Pdpn
podoplanin
chr4_-_143299463 0.904 ENSMUST00000119654.1
 Pdpn
podoplanin
chr19_-_8929323 0.853 ENSMUST00000096242.3
 Rom1
rod outer segment membrane protein 1
chr10_-_88605017 0.823 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr5_+_103754560 0.800 ENSMUST00000153165.1
ENSMUST00000031256.5
 Aff1

AF4/FMR2 family, member 1

chr4_+_141239499 0.723 ENSMUST00000141834.2
 Arhgef19
Rho guanine nucleotide exchange factor (GEF) 19
chr5_-_135251209 0.647 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr2_-_130397525 0.608 ENSMUST00000028897.7
 Cpxm1
carboxypeptidase X 1 (M14 family)
chr19_+_8929628 0.605 ENSMUST00000096241.4
 Eml3
echinoderm microtubule associated protein like 3
chr7_-_110862944 0.526 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr10_+_62920648 0.507 ENSMUST00000144459.1
 Slc25a16
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
chr10_+_62920630 0.506 ENSMUST00000044977.3
 Slc25a16
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
chr14_+_20929416 0.505 ENSMUST00000022369.7
 Vcl
vinculin
chr3_+_96161981 0.493 ENSMUST00000054356.9
 Mtmr11
myotubularin related protein 11
chr5_+_8056527 0.477 ENSMUST00000148633.1
 Sri
sorcin
chr7_-_44997535 0.413 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr3_+_127791374 0.401 ENSMUST00000171621.1
 Tifa
TRAF-interacting protein with forkhead-associated domain
chr2_-_69206133 0.400 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_-_25281801 0.396 ENSMUST00000102994.3
 Ufl1
UFM1 specific ligase 1
chr2_+_121866918 0.395 ENSMUST00000078752.3
ENSMUST00000110586.3
 Casc4

cancer susceptibility candidate 4

chr11_+_82101836 0.382 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr2_+_121867083 0.380 ENSMUST00000089912.5
ENSMUST00000089915.3
 Casc4

cancer susceptibility candidate 4

chr13_+_66932802 0.375 ENSMUST00000021990.3
 Ptdss1
phosphatidylserine synthase 1
chr5_+_140505550 0.372 ENSMUST00000043050.8
ENSMUST00000124142.1
 Chst12

carbohydrate sulfotransferase 12

chr10_-_121626316 0.368 ENSMUST00000039810.7
 Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr12_+_35047180 0.366 ENSMUST00000048519.9
ENSMUST00000163677.1
 Snx13

sorting nexin 13

chr3_+_65109343 0.343 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr2_-_69206146 0.298 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr4_-_25281752 0.294 ENSMUST00000038705.7
 Ufl1
UFM1 specific ligase 1
chr2_-_20943413 0.291 ENSMUST00000140230.1
 Arhgap21
Rho GTPase activating protein 21
chr3_-_59262825 0.278 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr5_+_110839973 0.244 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr8_+_25532125 0.226 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1
chr15_+_41789495 0.225 ENSMUST00000090095.5
ENSMUST00000022918.7
 Oxr1

oxidation resistance 1

chr8_+_46739745 0.209 ENSMUST00000034041.7
 Irf2
interferon regulatory factor 2
chr3_-_108044801 0.206 ENSMUST00000178808.1
ENSMUST00000106670.1
ENSMUST00000029489.8
 Gstm4


glutathione S-transferase, mu 4


chr9_+_65214690 0.185 ENSMUST00000069000.7
 Parp16
poly (ADP-ribose) polymerase family, member 16
chr1_+_127306706 0.182 ENSMUST00000171405.1
 Mgat5
mannoside acetylglucosaminyltransferase 5
chr6_+_30401866 0.167 ENSMUST00000068240.6
ENSMUST00000068259.6
 Klhdc10

kelch domain containing 10

chr14_-_37135126 0.159 ENSMUST00000042564.9
 Ghitm
growth hormone inducible transmembrane protein
chr11_-_116086929 0.121 ENSMUST00000074628.6
ENSMUST00000106444.3
 Wbp2

WW domain binding protein 2

chr1_+_75382114 0.114 ENSMUST00000113590.1
ENSMUST00000148515.1
 Speg

SPEG complex locus

chr2_-_127831817 0.094 ENSMUST00000028858.7
 Bub1
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
chr4_+_139352587 0.090 ENSMUST00000147999.1
ENSMUST00000042096.7
ENSMUST00000179784.1
ENSMUST00000082262.7
 Ubr4
Emc1


ubiquitin protein ligase E3 component n-recognin 4
ER membrane protein complex subunit 1


chr8_-_12672135 0.075 ENSMUST00000000776.8
 Tubgcp3
tubulin, gamma complex associated protein 3
chr4_+_94556546 0.066 ENSMUST00000094969.1
 Gm10306
predicted gene 10306
chr1_-_136260873 0.057 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr14_-_37135310 0.052 ENSMUST00000165649.2
 Ghitm
growth hormone inducible transmembrane protein
chr5_+_7179299 0.048 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr15_+_99972780 0.039 ENSMUST00000100206.2
 Larp4
La ribonucleoprotein domain family, member 4
chr1_+_72307413 0.027 ENSMUST00000027379.8
 Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0072034 renal vesicle induction(GO:0072034)
0.7 2.0 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
0.5 1.5 GO:1900133 renin secretion into blood stream(GO:0002001) negative regulation of urine volume(GO:0035811) regulation of renin secretion into blood stream(GO:1900133)
0.4 2.9 GO:0001887 selenium compound metabolic process(GO:0001887)
0.3 1.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 1.8 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 0.4 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.1 0.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.4 GO:0051031 tRNA transport(GO:0051031)
0.1 0.5 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.1 0.7 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 1.0 GO:0033280 response to vitamin D(GO:0033280)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 1.4 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841)
0.1 0.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 1.4 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 0.5 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 1.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 1.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.3 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.9 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.2 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.4 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.5 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.2 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.0 0.3 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.1 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.2 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:1990357 terminal web(GO:1990357)
0.2 0.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.7 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.6 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 3.5 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 2.0 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.2 GO:0005884 actin filament(GO:0005884)
0.0 1.8 GO:0005770 late endosome(GO:0005770)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0051379 epinephrine binding(GO:0051379)
0.2 0.7 GO:0071568 UFM1 transferase activity(GO:0071568)
0.2 2.0 GO:0039706 co-receptor binding(GO:0039706)
0.2 2.9 GO:0008430 selenium binding(GO:0008430)
0.2 1.8 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.1 1.4 GO:0005522 profilin binding(GO:0005522)
0.1 0.4 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.4 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.1 1.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 1.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 2.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.3 GO:0070402 NADPH binding(GO:0070402)
0.0 2.1 GO:0015293 symporter activity(GO:0015293)
0.0 1.2 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.4 GO:0015932 nucleobase-containing compound transmembrane transporter activity(GO:0015932)
0.0 0.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)