Motif ID: Mecp2

Z-value: 2.181


Transcription factors associated with Mecp2:

Gene SymbolEntrez IDGene Name
Mecp2 ENSMUSG00000031393.10 Mecp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecp2mm10_v2_chrX_-_74085656_740856900.048.2e-01Click!


Activity profile for motif Mecp2.

activity profile for motif Mecp2


Sorted Z-values histogram for motif Mecp2

Sorted Z-values for motif Mecp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_68386821 8.560 ENSMUST00000021284.3
 Ntn1
netrin 1
chr11_-_68386974 6.085 ENSMUST00000135141.1
 Ntn1
netrin 1
chr5_+_127241807 5.798 ENSMUST00000119026.1
 Tmem132c
transmembrane protein 132C
chr8_-_87959560 5.536 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_-_72788952 5.418 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_25250720 5.377 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr11_-_89302545 5.104 ENSMUST00000061728.3
 Nog
noggin
chr7_+_65862029 5.068 ENSMUST00000055576.5
ENSMUST00000098391.4
 Pcsk6

proprotein convertase subtilisin/kexin type 6

chr11_+_98412461 4.700 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr2_+_27886416 4.434 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr6_-_72789240 3.974 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr10_-_8886033 3.964 ENSMUST00000015449.5
 Sash1
SAM and SH3 domain containing 1
chr2_+_91457501 3.919 ENSMUST00000028689.3
 Lrp4
low density lipoprotein receptor-related protein 4
chr13_-_29984219 3.808 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr11_-_100850724 3.777 ENSMUST00000004143.2
 Stat5b
signal transducer and activator of transcription 5B
chr5_-_37824580 3.774 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr11_+_112782182 3.686 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr8_-_90348126 3.661 ENSMUST00000176034.1
ENSMUST00000176616.1
 Tox3

TOX high mobility group box family member 3

chr12_+_3806513 3.623 ENSMUST00000172719.1
 Dnmt3a
DNA methyltransferase 3A
chr10_-_42583628 3.615 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,130 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 16.3 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
1.4 12.9 GO:0046499 S-adenosylmethioninamine metabolic process(GO:0046499)
3.1 9.2 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.3 9.1 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.2 7.1 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.4 6.9 GO:0061181 regulation of chondrocyte development(GO:0061181)
1.4 6.9 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.3 6.9 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
1.1 6.7 GO:0090193 positive regulation of glomerulus development(GO:0090193)
0.6 6.5 GO:0061032 visceral serous pericardium development(GO:0061032)
1.6 6.4 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 6.4 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
1.2 6.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.7 5.9 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.3 5.7 GO:0071539 protein localization to centrosome(GO:0071539)
1.4 5.6 GO:0000255 allantoin metabolic process(GO:0000255)
1.8 5.4 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.7 5.4 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
1.7 5.2 GO:0048352 neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352)
1.3 5.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 382 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 82.9 GO:1903561 extracellular organelle(GO:0043230) extracellular vesicle(GO:1903561)
0.2 63.7 GO:0005667 transcription factor complex(GO:0005667)
0.2 27.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 22.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 19.3 GO:0005925 focal adhesion(GO:0005925)
0.3 18.4 GO:0005604 basement membrane(GO:0005604)
0.1 13.1 GO:0031012 extracellular matrix(GO:0031012)
0.6 12.7 GO:0001741 XY body(GO:0001741)
0.2 9.9 GO:0005581 collagen trimer(GO:0005581)
0.1 9.5 GO:0031526 brush border membrane(GO:0031526)
0.7 9.4 GO:0043219 lateral loop(GO:0043219)
0.2 9.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.6 8.8 GO:0016600 flotillin complex(GO:0016600)
0.0 8.7 GO:0005730 nucleolus(GO:0005730)
0.1 7.6 GO:0005811 lipid particle(GO:0005811)
1.2 7.1 GO:0016011 dystroglycan complex(GO:0016011)
0.1 7.1 GO:0005902 microvillus(GO:0005902)
2.2 6.6 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.5 6.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
2.1 6.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 650 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 16.8 GO:0005178 integrin binding(GO:0005178)
0.7 14.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 13.2 GO:0000975 regulatory region DNA binding(GO:0000975)
0.8 13.0 GO:0017166 vinculin binding(GO:0017166)
1.6 12.8 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.5 10.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 8.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 8.3 GO:0005109 frizzled binding(GO:0005109)
0.3 7.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 7.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 7.2 GO:0051015 actin filament binding(GO:0051015)
0.1 6.9 GO:0005496 steroid binding(GO:0005496)
1.0 6.8 GO:0034056 estrogen response element binding(GO:0034056)
0.2 6.6 GO:0071837 HMG box domain binding(GO:0071837)
0.4 6.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 6.1 GO:0008483 transaminase activity(GO:0008483)
0.7 6.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
1.1 5.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 5.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)