Motif ID: Mef2d_Mef2a

Z-value: 1.146

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2amm10_v2_chr7_-_67372846_673728580.951.0e-16Click!
Mef2dmm10_v2_chr3_+_88142328_881424830.754.4e-07Click!


Activity profile for motif Mef2d_Mef2a.

activity profile for motif Mef2d_Mef2a


Sorted Z-values histogram for motif Mef2d_Mef2a

Sorted Z-values for motif Mef2d_Mef2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_31872100 12.304 ENSMUST00000020543.6
ENSMUST00000109412.2
 Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr13_+_23934434 10.328 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr3_-_56183678 7.118 ENSMUST00000029374.6
 Nbea
neurobeachin
chr1_-_134234492 7.115 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr13_+_83573577 6.787 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr1_-_172297989 6.397 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr2_-_33371486 6.007 ENSMUST00000113165.1
 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr2_-_33371400 5.849 ENSMUST00000113164.1
ENSMUST00000091039.2
ENSMUST00000042615.6
 Ralgps1


Ral GEF with PH domain and SH3 binding motif 1


chr18_-_25753852 5.838 ENSMUST00000025117.6
ENSMUST00000115816.2
 Celf4

CUGBP, Elav-like family member 4

chr13_-_23934156 5.785 ENSMUST00000052776.2
 Hist1h2ba
histone cluster 1, H2ba
chr10_+_90576872 5.673 ENSMUST00000182550.1
ENSMUST00000099364.5
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr16_+_7069825 5.670 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_-_168712853 5.631 ENSMUST00000123156.1
ENSMUST00000156555.1
 Atp9a

ATPase, class II, type 9A

chr19_+_38264761 5.416 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr9_-_101198999 5.274 ENSMUST00000066773.7
 Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr16_+_45093611 5.231 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr1_-_64122256 5.218 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr12_-_34528844 5.100 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr5_+_66745835 5.074 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr12_+_52699297 4.980 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.3 GO:0006342 chromatin silencing(GO:0006342)
1.4 13.7 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.9 13.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
2.4 11.9 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.9 9.6 GO:0042572 retinol metabolic process(GO:0042572)
2.7 8.0 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 7.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 7.7 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
1.3 7.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
2.4 7.1 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
2.3 6.8 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
2.1 6.4 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.4 6.1 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.2 6.0 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.2 5.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
1.0 5.8 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.5 5.7 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 5.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.1 5.4 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
1.8 5.3 GO:0007525 somatic muscle development(GO:0007525)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.7 GO:0005802 trans-Golgi network(GO:0005802)
0.8 15.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.3 8.8 GO:0000788 nuclear nucleosome(GO:0000788)
1.2 8.6 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.4 7.1 GO:0032279 asymmetric synapse(GO:0032279)
0.1 6.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.7 GO:0016607 nuclear speck(GO:0016607)
0.9 6.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 6.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 6.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 5.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 5.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 5.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 5.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 5.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 4.9 GO:0005667 transcription factor complex(GO:0005667)
1.6 4.7 GO:0014802 terminal cisterna(GO:0014802)
0.0 4.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.9 4.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.1 4.3 GO:0090537 CERF complex(GO:0090537)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 13.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
2.0 12.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.7 11.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 10.4 GO:0051018 protein kinase A binding(GO:0051018)
0.0 9.0 GO:0008017 microtubule binding(GO:0008017)
1.2 8.6 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.4 7.3 GO:0030275 LRR domain binding(GO:0030275)
1.0 7.1 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.8 6.4 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239)
0.1 6.3 GO:0030674 protein binding, bridging(GO:0030674)
0.3 6.1 GO:0004385 guanylate kinase activity(GO:0004385)
1.5 6.0 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 5.9 GO:0003729 mRNA binding(GO:0003729)
0.3 5.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 5.4 GO:0043531 ADP binding(GO:0043531)
0.2 5.2 GO:0001968 fibronectin binding(GO:0001968)
0.5 5.1 GO:0003680 AT DNA binding(GO:0003680)
0.3 5.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.6 5.0 GO:0043495 protein anchor(GO:0043495)
0.8 4.8 GO:0070699 type II activin receptor binding(GO:0070699)