Motif ID: Mnx1_Lhx6_Lmx1a

Z-value: 0.785

Transcription factors associated with Mnx1_Lhx6_Lmx1a:

Gene SymbolEntrez IDGene Name
Lhx6 ENSMUSG00000026890.13 Lhx6
Lmx1a ENSMUSG00000026686.8 Lmx1a
Mnx1 ENSMUSG00000001566.8 Mnx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx6mm10_v2_chr2_-_36104060_36104073-0.326.8e-02Click!
Lmx1amm10_v2_chr1_+_167689108_1676892390.308.9e-02Click!


Activity profile for motif Mnx1_Lhx6_Lmx1a.

activity profile for motif Mnx1_Lhx6_Lmx1a


Sorted Z-values histogram for motif Mnx1_Lhx6_Lmx1a

Sorted Z-values for motif Mnx1_Lhx6_Lmx1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_20737306 5.016 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr5_+_139543889 4.154 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr3_+_55782500 3.370 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr8_-_61902669 3.100 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr6_-_147264124 2.803 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr14_-_118052235 2.121 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr1_-_172027269 2.117 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr1_-_172027251 1.922 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)
chr3_+_125404292 1.864 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_125404072 1.821 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr8_+_45658666 1.725 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 1.645 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr4_-_45532470 1.521 ENSMUST00000147448.1
 Shb
src homology 2 domain-containing transforming protein B
chr16_-_45724600 1.478 ENSMUST00000096057.4
 Tagln3
transgelin 3
chr4_-_155056784 1.423 ENSMUST00000131173.2
 Plch2
phospholipase C, eta 2
chr19_+_44493472 1.308 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr3_-_116253467 1.307 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr10_+_4611971 1.279 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr9_+_119063429 1.257 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr17_+_17402672 1.237 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.3 4.0 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 3.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 3.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.2 3.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.5 2.8 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 2.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.7 2.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 2.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 1.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.2 1.5 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 1.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 1.4 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.4 1.3 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 1.2 GO:0060539 diaphragm development(GO:0060539)
0.1 1.2 GO:0080111 DNA demethylation(GO:0080111)
0.1 1.2 GO:0097352 autophagosome maturation(GO:0097352)
0.4 1.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 1.1 GO:0021860 pyramidal neuron development(GO:0021860)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 4.0 GO:0060187 cell pole(GO:0060187)
0.0 3.4 GO:0070469 respiratory chain(GO:0070469)
0.1 3.1 GO:0002102 podosome(GO:0002102)
0.1 2.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.0 GO:0000792 heterochromatin(GO:0000792)
0.1 1.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.9 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.6 GO:0008623 CHRAC(GO:0008623)
0.1 0.6 GO:0031523 Myb complex(GO:0031523)
0.0 0.6 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.4 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.7 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 3.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 2.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 2.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 2.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.2 1.4 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.4 1.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 1.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.2 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 1.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 1.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.0 GO:0008483 transaminase activity(GO:0008483)
0.0 1.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)