Motif ID: Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 0.540

Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6:

Gene SymbolEntrez IDGene Name
Barx1 ENSMUSG00000021381.4 Barx1
Dlx6 ENSMUSG00000029754.7 Dlx6
Lhx9 ENSMUSG00000019230.8 Lhx9
Msx1 ENSMUSG00000048450.10 Msx1
Rax ENSMUSG00000024518.3 Rax

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Raxmm10_v2_chr18_-_65939048_65939089-0.512.4e-03Click!
Msx1mm10_v2_chr5_-_37824580_37824584-0.336.3e-02Click!
Lhx9mm10_v2_chr1_-_138848576_138848603-0.291.1e-01Click!
Dlx6mm10_v2_chr6_+_6863769_6863797-0.096.2e-01Click!


Activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6.

activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6


Sorted Z-values histogram for motif Msx1_Lhx9_Barx1_Rax_Dlx6

Sorted Z-values for motif Msx1_Lhx9_Barx1_Rax_Dlx6



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Top targets:


Showing 1 to 20 of 177 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_134747241 3.521 ENSMUST00000015138.9
 Eln
elastin
chr5_-_62766153 3.493 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_136171722 3.101 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr9_+_118478344 3.000 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 2.952 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr1_-_155417394 2.870 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr8_+_54954728 2.808 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr2_+_116067213 2.740 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr1_-_155417283 2.514 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr7_+_126950518 2.192 ENSMUST00000106335.1
ENSMUST00000146017.1
 Sez6l2

seizure related 6 homolog like 2

chr9_-_40346290 2.095 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr16_+_45093611 1.967 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr7_+_126950687 1.933 ENSMUST00000106333.1
 Sez6l2
seizure related 6 homolog like 2
chr2_-_116067391 1.894 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr4_-_14621805 1.853 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr16_+_42907563 1.621 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr17_-_90088343 1.492 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr7_+_126950837 1.488 ENSMUST00000106332.1
 Sez6l2
seizure related 6 homolog like 2
chr11_-_87359011 1.466 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr19_+_26749726 1.458 ENSMUST00000175842.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 6.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 5.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.9 5.4 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 3.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.5 3.2 GO:0019532 oxalate transport(GO:0019532)
0.2 3.1 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 2.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.2 1.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 1.8 GO:0016198 axon choice point recognition(GO:0016198)
0.0 1.8 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 1.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 1.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 1.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 1.4 GO:0098792 xenophagy(GO:0098792)
0.3 1.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.4 1.2 GO:0050975 sensory perception of touch(GO:0050975)
0.4 1.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 1.2 GO:0048305 immunoglobulin secretion(GO:0048305)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.5 GO:0071953 elastic fiber(GO:0071953)
0.1 3.2 GO:0071565 nBAF complex(GO:0071565)
0.3 3.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.9 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.5 GO:0043205 fibril(GO:0043205)
0.1 1.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.5 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.2 GO:0030673 axolemma(GO:0030673)
0.1 1.1 GO:0031045 dense core granule(GO:0031045)
0.0 1.1 GO:0032420 stereocilium(GO:0032420)
0.1 1.0 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.8 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.6 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.6 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 5.4 GO:0001618 virus receptor activity(GO:0001618)
0.1 4.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 3.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 3.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 2.8 GO:0005262 calcium channel activity(GO:0005262)
0.1 2.0 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 1.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 1.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.8 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.8 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.8 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)