Motif ID: Msx2_Hoxd4

Z-value: 0.880

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.105.7e-01Click!


Activity profile for motif Msx2_Hoxd4.

activity profile for motif Msx2_Hoxd4


Sorted Z-values histogram for motif Msx2_Hoxd4

Sorted Z-values for motif Msx2_Hoxd4



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Showing 1 to 20 of 144 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 13.245 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_62765618 7.116 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_159737510 4.771 ENSMUST00000111669.3
 Tnr
tenascin R
chr3_+_62419668 4.405 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr6_-_36811361 4.230 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr15_-_37459327 3.166 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr2_-_63184253 3.035 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr1_-_163725123 2.846 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr12_+_74297474 2.751 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr14_-_88471396 2.680 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr12_+_38783503 2.652 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr1_-_190170671 2.105 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr1_+_165788681 2.098 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr3_-_66296807 2.076 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1
chr4_+_136143497 2.013 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr15_+_92597104 1.794 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr1_+_165788746 1.749 ENSMUST00000161559.2
 Cd247
CD247 antigen
chr17_-_90088343 1.746 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr2_-_63184170 1.640 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr14_+_54259227 1.603 ENSMUST00000041197.7
 Abhd4
abhydrolase domain containing 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 4.8 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 4.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 4.7 GO:0051291 protein heterooligomerization(GO:0051291)
0.2 4.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
1.4 4.2 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 3.8 GO:0050852 T cell receptor signaling pathway(GO:0050852)
1.1 3.3 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 2.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 2.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 2.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 2.0 GO:0071398 cellular response to fatty acid(GO:0071398)
0.3 1.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 1.6 GO:0019915 lipid storage(GO:0019915)
0.0 1.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.5 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.5 1.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 1.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.4 GO:0007097 nuclear migration(GO:0007097)
0.0 1.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 1.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 4.8 GO:0072534 perineuronal net(GO:0072534)
0.0 4.2 GO:0031594 neuromuscular junction(GO:0031594)
1.0 3.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.1 1.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.2 GO:0070688 MLL5-L complex(GO:0070688)
0.1 1.2 GO:0071439 clathrin complex(GO:0071439)
0.1 1.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 0.9 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 0.7 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 0.6 GO:0031673 H zone(GO:0031673)
0.1 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.6 GO:0044327 dendritic spine head(GO:0044327)
0.2 0.5 GO:0055087 Ski complex(GO:0055087)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 21.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 4.8 GO:0046625 sphingolipid binding(GO:0046625)
0.2 4.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 4.7 GO:0043014 alpha-tubulin binding(GO:0043014)
1.4 4.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.4 3.3 GO:0050693 LBD domain binding(GO:0050693)
0.0 2.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 2.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 2.0 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.8 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.1 1.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 1.6 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 1.6 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.1 1.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.4 GO:0004601 peroxidase activity(GO:0004601)
0.1 1.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 1.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 1.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)