Motif ID: Msx3

Z-value: 0.470


Transcription factors associated with Msx3:

Gene SymbolEntrez IDGene Name
Msx3 ENSMUSG00000025469.9 Msx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx3mm10_v2_chr7_-_140049140_1400491800.057.9e-01Click!


Activity profile for motif Msx3.

activity profile for motif Msx3


Sorted Z-values histogram for motif Msx3

Sorted Z-values for motif Msx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_53975246 3.114 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chrX_-_143933204 2.794 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 2.095 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_-_45117349 1.881 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr1_-_158356258 1.816 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr15_+_82252397 1.462 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr13_+_83732438 1.461 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr5_+_14514918 1.328 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr1_-_52190901 1.297 ENSMUST00000156887.1
ENSMUST00000129107.1
 Gls

glutaminase

chr5_+_88583527 1.214 ENSMUST00000031229.6
 Rufy3
RUN and FYVE domain containing 3
chr4_-_14621805 1.160 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr17_+_21383725 1.157 ENSMUST00000056107.4
ENSMUST00000162659.1
 Zfp677

zinc finger protein 677

chr9_-_15301555 0.973 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr10_+_81257277 0.964 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr10_+_39612934 0.938 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr7_+_103550368 0.852 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr18_+_37819543 0.803 ENSMUST00000055935.5
 Pcdhga9
protocadherin gamma subfamily A, 9
chr11_+_70018421 0.785 ENSMUST00000108588.1
 Dlg4
discs, large homolog 4 (Drosophila)
chr6_+_8948608 0.725 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr16_+_11406618 0.712 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr7_-_127895578 0.699 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr12_-_84617326 0.664 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr8_+_72219726 0.630 ENSMUST00000003123.8
 Fam32a
family with sequence similarity 32, member A
chrX_-_75578188 0.617 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chr15_+_44787746 0.614 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr13_+_67863324 0.589 ENSMUST00000078471.5
 BC048507
cDNA sequence BC048507
chr3_-_41742471 0.563 ENSMUST00000026866.8
 Sclt1
sodium channel and clathrin linker 1
chr6_+_134640940 0.557 ENSMUST00000062755.8
 Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chrX_+_9885622 0.556 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr12_+_71136848 0.508 ENSMUST00000149564.1
ENSMUST00000045907.8
 2700049A03Rik

RIKEN cDNA 2700049A03 gene

chr18_+_57468478 0.496 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chrM_+_9870 0.467 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr11_+_116843278 0.461 ENSMUST00000106370.3
 Mettl23
methyltransferase like 23
chr3_-_116253467 0.456 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr4_-_14621494 0.436 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr10_+_88379217 0.430 ENSMUST00000130301.1
ENSMUST00000020251.8
 Gnptab

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

chr2_-_20943413 0.393 ENSMUST00000140230.1
 Arhgap21
Rho GTPase activating protein 21
chr10_-_76110956 0.374 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr10_-_85127977 0.365 ENSMUST00000050813.2
 Mterfd3
MTERF domain containing 3
chr3_+_94837533 0.337 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr8_+_107031218 0.321 ENSMUST00000034388.9
 Vps4a
vacuolar protein sorting 4a (yeast)
chr5_-_62766153 0.302 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_+_107255878 0.296 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
 Gpr174


G protein-coupled receptor 174


chr2_-_33087169 0.277 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr3_+_41742615 0.262 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr4_+_102254739 0.260 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_+_121956411 0.248 ENSMUST00000110578.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr4_-_129378116 0.219 ENSMUST00000030610.2
 Zbtb8a
zinc finger and BTB domain containing 8a
chr11_+_53433299 0.217 ENSMUST00000018382.6
 Gdf9
growth differentiation factor 9
chr7_+_3645267 0.209 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr16_-_75766758 0.200 ENSMUST00000114244.1
ENSMUST00000046283.8
 Hspa13

heat shock protein 70 family, member 13

chr2_-_33086366 0.196 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_125136692 0.184 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr12_+_102128718 0.166 ENSMUST00000159329.1
 Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr12_+_72441852 0.156 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr16_+_49699198 0.145 ENSMUST00000046777.4
ENSMUST00000142682.1
 Ift57

intraflagellar transport 57

chr3_+_138374121 0.136 ENSMUST00000171054.1
 Adh6-ps1
alcohol dehydrogenase 6 (class V), pseudogene 1
chr2_+_121956651 0.124 ENSMUST00000110574.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chrX_+_101449078 0.106 ENSMUST00000033674.5
 Itgb1bp2
integrin beta 1 binding protein 2
chr4_+_134930898 0.086 ENSMUST00000030622.2
 Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr7_-_99141068 0.079 ENSMUST00000037968.8
 Uvrag
UV radiation resistance associated gene
chr3_+_94837702 0.051 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
 Pogz


pogo transposable element with ZNF domain


chr1_-_172027269 0.047 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr8_+_69659263 0.030 ENSMUST00000169125.1
 Zfp964
zinc finger protein 964
chr10_+_88379127 0.025 ENSMUST00000127615.1
 Gnptab
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 4.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 1.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 0.7 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 1.3 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.2 1.4 GO:0019532 oxalate transport(GO:0019532)
0.2 0.5 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 0.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.3 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.4 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 1.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 0.8 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.9 GO:0048305 immunoglobulin secretion(GO:0048305)
0.0 0.2 GO:0042701 progesterone secretion(GO:0042701)
0.0 1.8 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 3.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 1.0 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.0 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0044316 cone cell pedicle(GO:0044316)
0.2 1.2 GO:0071437 invadopodium(GO:0071437)
0.1 0.6 GO:0071439 clathrin complex(GO:0071439)
0.1 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0090543 Flemming body(GO:0090543)
0.0 0.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.0 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0044292 dendrite terminus(GO:0044292)
0.0 1.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0004359 glutaminase activity(GO:0004359)
0.2 4.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.5 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 1.3 GO:0005522 profilin binding(GO:0005522)
0.1 0.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.7 GO:0048038 quinone binding(GO:0048038)
0.1 1.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 1.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.4 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0 1.0 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0 1.1 GO:0030276 clathrin binding(GO:0030276)
0.0 4.3 GO:0005096 GTPase activator activity(GO:0005096)