Motif ID: Mtf1

Z-value: 1.451


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.531.5e-03Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_94172618 30.229 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr8_+_94179089 19.181 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr11_-_32222233 11.658 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr11_+_63133068 10.582 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr11_+_63132569 9.995 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr1_+_191906743 7.423 ENSMUST00000044954.6
 Slc30a1
solute carrier family 30 (zinc transporter), member 1
chr1_+_135729147 6.860 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr4_+_134496996 5.541 ENSMUST00000095074.3
 Paqr7
progestin and adipoQ receptor family member VII
chr6_-_39118211 5.490 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr12_+_24572276 4.730 ENSMUST00000085553.5
 Grhl1
grainyhead-like 1 (Drosophila)
chr14_-_26170283 4.497 ENSMUST00000100809.4
 Plac9b
placenta specific 9b
chr5_+_105415738 4.411 ENSMUST00000112707.1
 Lrrc8b
leucine rich repeat containing 8 family, member B
chr9_-_14381242 3.676 ENSMUST00000167549.1
 Endod1
endonuclease domain containing 1
chr4_+_129984833 3.192 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr4_+_129985098 3.101 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr8_-_54529951 2.904 ENSMUST00000067476.8
 Spcs3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr1_-_166002613 2.864 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr9_-_56635624 2.579 ENSMUST00000114256.1
 Lingo1
leucine rich repeat and Ig domain containing 1
chr10_+_70245083 2.579 ENSMUST00000046807.6
 Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr3_-_121815212 2.534 ENSMUST00000029770.5
 Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr7_-_43313063 2.429 ENSMUST00000135130.1
ENSMUST00000139061.1
 Zfp715

zinc finger protein 715

chr17_+_71673255 2.400 ENSMUST00000097284.3
 Fam179a
family with sequence similarity 179, member A
chr3_-_94412883 2.396 ENSMUST00000181305.1
 1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr1_+_131867224 2.390 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr7_+_119793987 2.336 ENSMUST00000033218.8
ENSMUST00000106520.1
 2610020H08Rik

RIKEN cDNA 2610020H08 gene

chr1_-_166002591 2.295 ENSMUST00000111429.4
ENSMUST00000176800.1
 Pou2f1

POU domain, class 2, transcription factor 1

chr7_+_119794102 2.235 ENSMUST00000084644.2
 2610020H08Rik
RIKEN cDNA 2610020H08 gene
chr13_-_45964964 2.228 ENSMUST00000180110.1
ENSMUST00000091628.3
ENSMUST00000167708.2
 Atxn1


ataxin 1


chr1_+_167618246 2.115 ENSMUST00000111380.1
 Rxrg
retinoid X receptor gamma
chr7_+_132610620 1.994 ENSMUST00000033241.5
 Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr8_+_13159135 1.951 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr9_-_112187898 1.766 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr7_-_119793958 1.570 ENSMUST00000106523.1
ENSMUST00000063902.7
ENSMUST00000150844.1
 Eri2


exoribonuclease 2


chr5_-_125341043 1.530 ENSMUST00000111390.1
ENSMUST00000086075.6
 Scarb1

scavenger receptor class B, member 1

chr18_+_11839220 1.511 ENSMUST00000171109.1
ENSMUST00000046948.8
 Cables1

CDK5 and Abl enzyme substrate 1

chr3_+_107895916 1.444 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr9_+_78175898 1.425 ENSMUST00000180974.1
 C920006O11Rik
RIKEN cDNA C920006O11 gene
chr7_-_43313233 1.380 ENSMUST00000012796.7
ENSMUST00000107986.2
 Zfp715

zinc finger protein 715

chr3_+_107895821 1.316 ENSMUST00000004134.4
 Gstm5
glutathione S-transferase, mu 5
chr19_-_4839286 1.142 ENSMUST00000037246.5
 Ccs
copper chaperone for superoxide dismutase
chr2_-_130664565 1.119 ENSMUST00000089559.4
 Ddrgk1
DDRGK domain containing 1
chr16_-_91597636 1.094 ENSMUST00000023686.8
 Tmem50b
transmembrane protein 50B
chr15_-_58214882 1.040 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr13_+_23934434 1.030 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr19_-_41263931 1.015 ENSMUST00000025989.8
 Tm9sf3
transmembrane 9 superfamily member 3
chr18_-_84589491 0.958 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr3_+_107896247 0.935 ENSMUST00000169365.1
 Gstm5
glutathione S-transferase, mu 5
chr10_-_39899238 0.907 ENSMUST00000178563.1
 AA474331
expressed sequence AA474331
chr19_-_4615647 0.895 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr12_+_103532435 0.891 ENSMUST00000021631.5
 Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr5_-_123749393 0.885 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
 Rsrc2


arginine/serine-rich coiled-coil 2


chr19_-_4615453 0.851 ENSMUST00000053597.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr13_-_23934156 0.808 ENSMUST00000052776.2
 Hist1h2ba
histone cluster 1, H2ba
chr1_-_169531447 0.782 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_-_173119402 0.775 ENSMUST00000094287.3
ENSMUST00000179693.1
 Ctcfl

CCCTC-binding factor (zinc finger protein)-like

chr6_+_145746739 0.689 ENSMUST00000111704.1
 Rassf8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr1_-_169531343 0.679 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr5_-_123749371 0.670 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
 Rsrc2


arginine/serine-rich coiled-coil 2


chr10_+_81136223 0.662 ENSMUST00000048128.8
 Zbtb7a
zinc finger and BTB domain containing 7a
chr5_+_57718021 0.624 ENSMUST00000094783.3
ENSMUST00000068110.7
 Pcdh7

protocadherin 7

chr1_-_64122256 0.623 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr1_-_166309585 0.621 ENSMUST00000168347.1
 5330438I03Rik
RIKEN cDNA 5330438I03 gene
chr1_+_179668202 0.601 ENSMUST00000040538.3
 Sccpdh
saccharopine dehydrogenase (putative)
chr6_+_90619241 0.593 ENSMUST00000032177.8
 Slc41a3
solute carrier family 41, member 3
chr8_+_92827273 0.521 ENSMUST00000034187.7
 Mmp2
matrix metallopeptidase 2
chr1_+_75400070 0.472 ENSMUST00000113589.1
 Speg
SPEG complex locus
chr12_-_4592927 0.453 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr7_+_43579577 0.439 ENSMUST00000058104.7
 Zfp719
zinc finger protein 719
chr2_-_91236877 0.425 ENSMUST00000111352.1
 Ddb2
damage specific DNA binding protein 2
chr4_+_103619580 0.419 ENSMUST00000106827.1
 Dab1
disabled 1
chr5_+_115506668 0.395 ENSMUST00000067268.8
ENSMUST00000086523.3
 Pxn

paxillin

chr4_-_93335510 0.220 ENSMUST00000066774.4
 Tusc1
tumor suppressor candidate 1
chr16_+_22857845 0.196 ENSMUST00000004574.7
ENSMUST00000178320.1
ENSMUST00000166487.2
 Dnajb11


DnaJ (Hsp40) homolog, subfamily B, member 11


chr10_+_20952547 0.183 ENSMUST00000105525.4
 Ahi1
Abelson helper integration site 1
chr17_-_56716788 0.142 ENSMUST00000067931.5
 Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr2_+_150323702 0.121 ENSMUST00000133235.2
 Gm10130
predicted gene 10130
chr8_+_70905970 0.094 ENSMUST00000019405.2
 Map1s
microtubule-associated protein 1S
chr3_-_58692391 0.084 ENSMUST00000070368.7
 Siah2
seven in absentia 2
chr15_-_93519499 0.082 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr8_+_123373778 0.078 ENSMUST00000057934.3
ENSMUST00000108840.2
 Tcf25

transcription factor 25 (basic helix-loop-helix)

chr8_-_70776650 0.036 ENSMUST00000034296.8
 Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr6_-_83775767 0.029 ENSMUST00000014892.6
 Tex261
testis expressed gene 261
chr7_-_141539784 0.015 ENSMUST00000118694.1
ENSMUST00000153191.1
ENSMUST00000166082.1
ENSMUST00000026586.6
 Chid1



chitinase domain containing 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 56.8 GO:0061687 detoxification of inorganic compound(GO:0061687)
1.1 20.6 GO:0032060 bleb assembly(GO:0032060)
0.8 2.5 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.8 4.7 GO:0002934 desmosome organization(GO:0002934)
0.7 5.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.7 2.0 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.5 3.7 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.5 1.5 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.3 1.0 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 2.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 2.6 GO:0046415 urate metabolic process(GO:0046415)
0.2 1.6 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.2 11.7 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.2 1.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 0.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 2.6 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.1 0.4 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 6.9 GO:0070527 platelet aggregation(GO:0070527)
0.1 5.5 GO:0048477 oogenesis(GO:0048477)
0.1 2.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.2 GO:0030862 regulation of polarized epithelial cell differentiation(GO:0030860) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.1 1.1 GO:0019430 removal of superoxide radicals(GO:0019430)
0.1 0.9 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 1.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 1.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.0 4.4 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.2 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.8 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.4 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.7 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.2 GO:0016556 mRNA modification(GO:0016556)
0.0 1.0 GO:0006342 chromatin silencing(GO:0006342)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 20.6 GO:0043218 compact myelin(GO:0043218)
0.7 2.0 GO:0044194 cytolytic granule(GO:0044194)
0.3 3.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 1.5 GO:0031262 Ndc80 complex(GO:0031262)
0.1 2.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 2.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.5 GO:0031528 microvillus membrane(GO:0031528)
0.1 7.4 GO:0030315 T-tubule(GO:0030315)
0.0 17.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 11.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0045098 type III intermediate filament(GO:0045098)
0.0 3.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.9 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 7.3 GO:0005925 focal adhesion(GO:0005925)
0.0 1.0 GO:0030018 Z disc(GO:0030018)
0.0 1.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 5.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.5 2.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.5 7.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 2.0 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.4 20.3 GO:0005507 copper ion binding(GO:0005507)
0.3 5.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 2.2 GO:0034046 poly(G) binding(GO:0034046)
0.2 2.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 11.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.7 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 5.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 2.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 2.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 4.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 38.0 GO:0008270 zinc ion binding(GO:0008270)
0.0 3.1 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.6 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) NADPH:sulfur oxidoreductase activity(GO:0043914) epoxyqueuosine reductase activity(GO:0052693)
0.0 0.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.4 GO:0042169 SH2 domain binding(GO:0042169)