Motif ID: Nanog

Z-value: 0.862


Transcription factors associated with Nanog:

Gene SymbolEntrez IDGene Name
Nanog ENSMUSG00000012396.6 Nanog

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nanogmm10_v2_chr6_+_122707489_1227076080.467.3e-03Click!


Activity profile for motif Nanog.

activity profile for motif Nanog


Sorted Z-values histogram for motif Nanog

Sorted Z-values for motif Nanog



Network of associatons between targets according to the STRING database.



First level regulatory network of Nanog

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_78206408 4.518 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr3_+_62419668 4.100 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr14_+_65970610 3.642 ENSMUST00000127387.1
 Clu
clusterin
chr19_-_36736653 3.611 ENSMUST00000087321.2
 Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr10_-_25200110 3.520 ENSMUST00000100012.2
 Akap7
A kinase (PRKA) anchor protein 7
chr18_-_35215008 3.399 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr15_+_9436028 3.267 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr4_+_154960915 3.207 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr14_+_65971049 3.154 ENSMUST00000128539.1
 Clu
clusterin
chr1_+_146497614 3.153 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr11_-_109298121 2.958 ENSMUST00000020920.3
 Rgs9
regulator of G-protein signaling 9
chr14_+_65970804 2.955 ENSMUST00000138191.1
 Clu
clusterin
chr11_-_109298066 2.949 ENSMUST00000106706.1
 Rgs9
regulator of G-protein signaling 9
chr1_+_169655493 2.887 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5
chr4_+_20008357 2.734 ENSMUST00000117632.1
ENSMUST00000098244.1
 Ttpa

tocopherol (alpha) transfer protein

chr13_-_41273977 2.680 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr11_+_62248977 2.642 ENSMUST00000018644.2
 Adora2b
adenosine A2b receptor
chr4_-_109665249 2.589 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr11_-_20332689 2.505 ENSMUST00000109594.1
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_-_20332654 2.437 ENSMUST00000004634.6
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 9.8 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.2 7.4 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.4 6.5 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.7 4.9 GO:0015808 L-alanine transport(GO:0015808)
1.2 4.6 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.6 4.5 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.2 4.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 3.6 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.6 3.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 3.4 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.8 3.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 3.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 3.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 3.0 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.7 2.7 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 2.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 2.7 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.9 2.6 GO:0002678 positive regulation of chronic inflammatory response(GO:0002678)
0.1 2.3 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 2.2 GO:0097178 ruffle assembly(GO:0097178)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 9.8 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.2 7.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 5.4 GO:0005882 intermediate filament(GO:0005882)
0.1 4.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 3.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 3.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 3.6 GO:0042587 glycogen granule(GO:0042587)
0.5 2.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.4 GO:0005770 late endosome(GO:0005770)
0.0 2.1 GO:0009986 cell surface(GO:0009986)
0.1 1.7 GO:0097386 glial cell projection(GO:0097386)
0.0 1.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.5 GO:0005605 basal lamina(GO:0005605)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.3 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.3 GO:0005769 early endosome(GO:0005769)
0.0 1.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.0 GO:0014704 intercalated disc(GO:0014704)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.2 GO:0005096 GTPase activator activity(GO:0005096)
0.4 9.5 GO:0051787 misfolded protein binding(GO:0051787)
0.7 5.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.8 4.5 GO:0015265 urea channel activity(GO:0015265)
0.2 4.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 3.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 3.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 3.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 2.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 2.6 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 2.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.2 GO:0003785 actin monomer binding(GO:0003785)
0.4 2.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.3 2.1 GO:0048495 Roundabout binding(GO:0048495)
0.1 2.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.6 1.7 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)