Motif ID: Neurod2_Bhlha15_Bhlhe22_Olig1
Z-value: 0.832
Transcription factors associated with Neurod2_Bhlha15_Bhlhe22_Olig1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Bhlha15 | ENSMUSG00000052271.7 | Bhlha15 |
| Bhlhe22 | ENSMUSG00000025128.6 | Bhlhe22 |
| Neurod2 | ENSMUSG00000038255.6 | Neurod2 |
| Olig1 | ENSMUSG00000046160.5 | Olig1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bhlhe22 | mm10_v2_chr3_+_18054258_18054325 | 0.82 | 6.9e-09 | Click! |
| Neurod2 | mm10_v2_chr11_-_98329641_98329654 | 0.75 | 6.2e-07 | Click! |
| Olig1 | mm10_v2_chr16_+_91269759_91269778 | -0.23 | 2.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 8.3 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 1.4 | 5.8 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 1.0 | 4.8 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.9 | 2.8 | GO:0032240 | RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.7 | 3.9 | GO:0032796 | uropod organization(GO:0032796) |
| 0.6 | 2.5 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.5 | 2.4 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) |
| 0.5 | 1.4 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.4 | 5.8 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.3 | 1.5 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.2 | 0.9 | GO:0030397 | membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081) |
| 0.2 | 1.9 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.2 | 2.7 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.2 | 0.5 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 0.2 | 1.3 | GO:0061368 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.2 | 13.4 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.2 | 0.8 | GO:2000302 | regulation of synaptic vesicle endocytosis(GO:1900242) positive regulation of synaptic vesicle exocytosis(GO:2000302) |
| 0.1 | 1.9 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.1 | 1.8 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 1.1 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.1 | 1.5 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.1 | 1.2 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.1 | 0.8 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.1 | 1.7 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.1 | 0.7 | GO:0043416 | regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 0.1 | 0.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 3.5 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.1 | 1.8 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.1 | 0.6 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.1 | 0.1 | GO:0032714 | negative regulation of interleukin-5 production(GO:0032714) |
| 0.1 | 0.3 | GO:0046294 | formaldehyde catabolic process(GO:0046294) |
| 0.1 | 0.3 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.1 | 0.2 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.1 | 1.2 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.4 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.0 | 3.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.1 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
| 0.0 | 0.3 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 1.1 | GO:0001523 | retinoid metabolic process(GO:0001523) |
| 0.0 | 0.3 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 0.1 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
| 0.0 | 6.2 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 1.8 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.0 | 0.7 | GO:0021702 | cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.0 | 1.3 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 0.0 | 0.1 | GO:0006545 | glycine biosynthetic process(GO:0006545) |
| 0.0 | 0.5 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 0.7 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 2.0 | GO:0000045 | autophagosome assembly(GO:0000045) |
| 0.0 | 0.6 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.5 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.0 | 0.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 1.7 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 1.9 | GO:0046889 | positive regulation of lipid biosynthetic process(GO:0046889) |
| 0.0 | 0.1 | GO:0030578 | PML body organization(GO:0030578) |
| 0.0 | 1.1 | GO:0051438 | regulation of ubiquitin-protein transferase activity(GO:0051438) |
| 0.0 | 1.1 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 0.3 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.1 | GO:0045760 | positive regulation of action potential(GO:0045760) |
| 0.0 | 0.1 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
| 0.0 | 0.1 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.0 | 3.5 | GO:0032259 | methylation(GO:0032259) |
| 0.0 | 0.0 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
| 0.0 | 0.2 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.8 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.5 | 2.7 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.3 | 4.8 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.2 | 11.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.2 | 2.8 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 0.8 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.2 | 5.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.2 | 2.9 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.2 | 3.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 1.5 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.1 | 1.9 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.9 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.1 | 1.9 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 1.1 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.1 | 1.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 1.1 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.7 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.3 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.0 | 0.8 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 2.0 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.2 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.0 | 0.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.7 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 1.1 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 3.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.9 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.3 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 0.4 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 0.3 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 0.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.1 | GO:0000306 | extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 0.2 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 0.1 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 1.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.2 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.6 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.1 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 1.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.5 | GO:0043198 | dendritic shaft(GO:0043198) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.8 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.4 | 3.9 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.3 | 1.8 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.3 | 1.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 11.5 | GO:0070888 | E-box binding(GO:0070888) |
| 0.3 | 1.9 | GO:0045703 | pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703) |
| 0.2 | 0.9 | GO:0070012 | oligopeptidase activity(GO:0070012) |
| 0.2 | 4.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 2.9 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.2 | 1.5 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 1.6 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.1 | 2.4 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 5.6 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 3.7 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 0.9 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.1 | 0.9 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 0.7 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 1.8 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 0.4 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.1 | 2.7 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 0.3 | GO:0018738 | S-formylglutathione hydrolase activity(GO:0018738) |
| 0.1 | 0.8 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 0.3 | GO:0035851 | histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851) |
| 0.1 | 1.8 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.1 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 6.3 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 1.7 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.6 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 0.8 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.1 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.0 | 3.2 | GO:0043851 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012) |
| 0.0 | 1.3 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 1.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.5 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.0 | 0.9 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.3 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.1 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.0 | 0.7 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 1.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 0.2 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 0.3 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.0 | 0.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.7 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 0.1 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.0 | 2.7 | GO:0015293 | symporter activity(GO:0015293) |
| 0.0 | 1.8 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 0.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 1.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.1 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
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