Motif ID: Nfatc1

Z-value: 5.198


Transcription factors associated with Nfatc1:

Gene SymbolEntrez IDGene Name
Nfatc1 ENSMUSG00000033016.9 Nfatc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc1mm10_v2_chr18_-_80713062_80713080-0.327.3e-02Click!


Activity profile for motif Nfatc1.

activity profile for motif Nfatc1


Sorted Z-values histogram for motif Nfatc1

Sorted Z-values for motif Nfatc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3000922 121.801 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 121.273 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3004457 118.660 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3013140 110.379 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 107.017 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3037111 103.736 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3036877 97.340 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3025417 96.194 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3034599 93.862 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3005125 91.876 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3017408 89.228 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr14_-_19418930 80.117 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3015654 76.572 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr2_-_98667264 73.882 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3018753 72.184 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_+_98662227 59.035 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr10_+_26229707 10.444 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr10_+_4611971 9.401 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr3_+_94377432 8.822 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr6_+_15185203 7.941 ENSMUST00000154448.1
 Foxp2
forkhead box P2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 646.2 GO:0008150 biological_process(GO:0008150)
2.2 15.5 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
1.9 11.1 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.3 10.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
2.4 9.4 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.7 7.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 7.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.8 6.4 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
2.1 6.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.0 5.5 GO:0051028 mRNA transport(GO:0051028)
1.2 5.0 GO:0032439 endosome localization(GO:0032439)
1.2 4.9 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.3 4.7 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.4 4.1 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
1.2 3.7 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
1.8 3.6 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.5 3.6 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 3.3 GO:0048730 epidermis morphogenesis(GO:0048730)
0.1 3.1 GO:0042491 auditory receptor cell differentiation(GO:0042491)
1.0 2.9 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 749.7 GO:0005575 cellular_component(GO:0005575)
0.4 7.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.3 6.4 GO:0000242 pericentriolar material(GO:0000242)
0.8 5.0 GO:0045179 apical cortex(GO:0045179)
0.1 4.1 GO:0044295 axonal growth cone(GO:0044295)
0.9 3.6 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 2.9 GO:0036038 MKS complex(GO:0036038)
0.1 2.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.5 2.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 2.4 GO:0016580 Sin3 complex(GO:0016580)
0.3 2.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.6 2.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 2.1 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.6 1.7 GO:0071914 prominosome(GO:0071914)
0.1 1.4 GO:0005652 nuclear lamina(GO:0005652)
0.4 1.1 GO:0000811 GINS complex(GO:0000811)
0.2 0.9 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.8 GO:0061574 ASAP complex(GO:0061574)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 691.2 GO:0003674 molecular_function(GO:0003674)
3.9 15.5 GO:0008142 oxysterol binding(GO:0008142)
0.3 11.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 9.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
3.1 9.4 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 8.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.3 6.4 GO:0042610 CD8 receptor binding(GO:0042610)
1.0 4.9 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.6 4.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 4.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 4.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 4.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 4.0 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 3.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.7 3.6 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 2.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 2.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 2.3 GO:0042805 actinin binding(GO:0042805)
0.4 2.2 GO:0005113 patched binding(GO:0005113)