Motif ID: Nfatc4

Z-value: 0.574


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.392.5e-02Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_56978534 4.298 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_48049080 3.088 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr13_+_83504032 2.969 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_-_56969864 2.753 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_+_26623419 2.731 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr19_-_4943049 2.505 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr2_+_55435918 1.689 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr2_-_66410064 1.449 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr11_+_97415527 1.388 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr5_+_117363513 1.183 ENSMUST00000111959.1
 Wsb2
WD repeat and SOCS box-containing 2
chr19_-_8839181 1.145 ENSMUST00000096259.4
 Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr13_-_52981027 1.012 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr1_-_126830632 0.994 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr9_+_113812547 0.982 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr6_-_59024470 0.910 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr14_+_70555900 0.850 ENSMUST00000163060.1
 Hr
hairless
chrX_+_7638674 0.808 ENSMUST00000128890.1
 Syp
synaptophysin
chr12_+_76533540 0.793 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr9_-_13446753 0.748 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr1_-_193370225 0.744 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_-_193370260 0.708 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr2_-_116067391 0.701 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr11_+_29692937 0.693 ENSMUST00000102843.3
ENSMUST00000102842.3
ENSMUST00000078830.4
ENSMUST00000170731.1
 Rtn4



reticulon 4



chr6_-_59024340 0.672 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr1_+_34005872 0.653 ENSMUST00000182296.1
 Dst
dystonin
chr2_+_116067213 0.650 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr16_+_43364145 0.594 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr8_-_64205970 0.583 ENSMUST00000066166.4
 Tll1
tolloid-like
chr14_+_47663756 0.570 ENSMUST00000022391.7
 Ktn1
kinectin 1
chr10_+_100488289 0.541 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr7_-_4778141 0.529 ENSMUST00000094892.5
 Il11
interleukin 11
chr2_-_73660351 0.471 ENSMUST00000154258.1
 Chn1
chimerin (chimaerin) 1
chr3_-_96594128 0.450 ENSMUST00000145001.1
ENSMUST00000091924.3
 Polr3gl

polymerase (RNA) III (DNA directed) polypeptide G like

chr2_+_125136692 0.412 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr1_-_64121456 0.408 ENSMUST00000142009.1
ENSMUST00000114086.1
 Klf7

Kruppel-like factor 7 (ubiquitous)

chr12_-_84450944 0.357 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr15_+_92051153 0.350 ENSMUST00000169825.1
 Cntn1
contactin 1
chr19_+_8839298 0.348 ENSMUST00000160556.1
 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr3_+_94837533 0.302 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr8_-_41041828 0.276 ENSMUST00000051379.7
 Mtus1
mitochondrial tumor suppressor 1
chr15_-_79062866 0.273 ENSMUST00000151889.1
ENSMUST00000040676.4
 Ankrd54

ankyrin repeat domain 54

chr11_-_35980473 0.264 ENSMUST00000018993.6
 Wwc1
WW, C2 and coiled-coil domain containing 1
chr11_+_75468040 0.264 ENSMUST00000043598.7
ENSMUST00000108435.1
 Tlcd2

TLC domain containing 2

chr1_-_64121389 0.242 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr1_-_126830786 0.240 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr19_+_8850785 0.235 ENSMUST00000096257.2
 Lrrn4cl
LRRN4 C-terminal like
chr18_-_62741387 0.222 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr4_+_130107556 0.213 ENSMUST00000030563.5
 Pef1
penta-EF hand domain containing 1
chrX_+_48623737 0.125 ENSMUST00000114936.1
 Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr3_+_88214474 0.108 ENSMUST00000181356.1
ENSMUST00000181396.1
 Gm3764

predicted gene 3764

chr2_-_169405435 0.104 ENSMUST00000131509.1
 4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr3_-_37125943 0.104 ENSMUST00000029275.5
 Il2
interleukin 2
chr4_-_148159838 0.098 ENSMUST00000151127.1
ENSMUST00000105705.2
 Fbxo44

F-box protein 44

chr12_+_91400990 0.082 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr8_-_67818284 0.078 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr14_+_120275669 0.066 ENSMUST00000088419.6
ENSMUST00000167459.1
 Mbnl2

muscleblind-like 2

chr7_-_79920599 0.038 ENSMUST00000075657.6
 Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chr14_-_25927672 0.026 ENSMUST00000185006.1
 Tmem254a
transmembrane protein 254a
chr3_-_152193803 0.016 ENSMUST00000050073.6
 Dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.0 3.0 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.8 2.5 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.4 7.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 2.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 1.0 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 1.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.7 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.4 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
0.1 0.4 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 1.7 GO:0010107 potassium ion import(GO:0010107)
0.1 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0060467 negative regulation of fertilization(GO:0060467)
0.0 1.0 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.7 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.3 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.3 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.3 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 0.7 GO:0031673 H zone(GO:0031673)
0.1 2.7 GO:0071564 npBAF complex(GO:0071564)
0.1 1.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 7.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 3.0 GO:0016607 nuclear speck(GO:0016607)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.0 GO:0030315 T-tubule(GO:0030315)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 3.0 GO:0003680 AT DNA binding(GO:0003680)
0.2 2.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.4 GO:0031402 sodium ion binding(GO:0031402)
0.1 1.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 1.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.9 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 2.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)