Motif ID: Nfe2l2
Z-value: 0.716
Transcription factors associated with Nfe2l2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfe2l2 | ENSMUSG00000015839.6 | Nfe2l2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfe2l2 | mm10_v2_chr2_-_75704535_75704641 | 0.44 | 1.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 7.4 | GO:0072180 | mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180) |
| 1.4 | 14.2 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 1.2 | 3.7 | GO:0060821 | inactivation of X chromosome by DNA methylation(GO:0060821) |
| 1.0 | 3.0 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 0.8 | 2.3 | GO:0097278 | complement-dependent cytotoxicity(GO:0097278) |
| 0.7 | 2.9 | GO:0048819 | positive regulation of keratinocyte proliferation(GO:0010838) regulation of hair follicle maturation(GO:0048819) regulation of catagen(GO:0051794) |
| 0.7 | 2.0 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.6 | 1.9 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
| 0.6 | 4.5 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.6 | 1.7 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.4 | 1.7 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.4 | 1.1 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 0.4 | 3.7 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
| 0.3 | 1.0 | GO:0009446 | putrescine biosynthetic process(GO:0009446) |
| 0.3 | 1.0 | GO:0070488 | neutrophil aggregation(GO:0070488) |
| 0.3 | 8.5 | GO:0071451 | cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) |
| 0.3 | 1.4 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 0.3 | 0.8 | GO:0002295 | T-helper cell lineage commitment(GO:0002295) |
| 0.3 | 1.5 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
| 0.2 | 0.7 | GO:0006065 | UDP-glucuronate biosynthetic process(GO:0006065) |
| 0.2 | 1.6 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.2 | 1.8 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.2 | 3.7 | GO:0090005 | negative regulation of establishment of protein localization to plasma membrane(GO:0090005) |
| 0.2 | 4.9 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.2 | 0.8 | GO:0035553 | oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.2 | 1.7 | GO:0019240 | citrulline biosynthetic process(GO:0019240) |
| 0.2 | 0.9 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.2 | 0.4 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.2 | 1.7 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.1 | 0.6 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.1 | 0.7 | GO:0051661 | maintenance of centrosome location(GO:0051661) regulation of microtubule motor activity(GO:2000574) |
| 0.1 | 2.2 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 1.0 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.1 | 2.1 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.1 | 1.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 0.4 | GO:1902512 | positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626) |
| 0.1 | 0.7 | GO:0042148 | strand invasion(GO:0042148) |
| 0.1 | 0.9 | GO:0051409 | response to nitrosative stress(GO:0051409) |
| 0.1 | 1.6 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.1 | 1.8 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.1 | 0.3 | GO:0002513 | tolerance induction to self antigen(GO:0002513) |
| 0.1 | 0.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 1.3 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.1 | 2.1 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.5 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.1 | 1.3 | GO:0061298 | retina vasculature development in camera-type eye(GO:0061298) |
| 0.1 | 0.1 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.1 | 0.4 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.1 | 0.9 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.1 | 0.8 | GO:0032620 | interleukin-17 production(GO:0032620) |
| 0.1 | 0.6 | GO:0090244 | Wnt signaling pathway involved in somitogenesis(GO:0090244) |
| 0.0 | 1.0 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.3 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) regulation of dendritic spine maintenance(GO:1902950) positive regulation of dendritic spine maintenance(GO:1902952) |
| 0.0 | 0.9 | GO:0048671 | negative regulation of collateral sprouting(GO:0048671) |
| 0.0 | 0.3 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.0 | 1.2 | GO:0045739 | positive regulation of DNA repair(GO:0045739) |
| 0.0 | 1.7 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.0 | 1.2 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.0 | 1.6 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 1.8 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 0.1 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
| 0.0 | 1.3 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 0.2 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.0 | 0.4 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.0 | 0.1 | GO:1900186 | negative regulation of clathrin-mediated endocytosis(GO:1900186) |
| 0.0 | 0.6 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 0.7 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 0.3 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 0.1 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.0 | 1.0 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.5 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.2 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 0.4 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.4 | GO:2000279 | negative regulation of DNA biosynthetic process(GO:2000279) |
| 0.0 | 0.6 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.0 | 0.3 | GO:0010831 | positive regulation of myotube differentiation(GO:0010831) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 14.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.6 | 1.7 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.4 | 1.3 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.3 | 3.0 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.3 | 3.3 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.3 | 2.3 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.3 | 5.0 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.3 | 0.9 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 0.3 | 1.1 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
| 0.3 | 3.0 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.3 | 0.8 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.3 | 1.6 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.3 | 6.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 7.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 1.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 0.8 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 0.7 | GO:0000235 | astral microtubule(GO:0000235) |
| 0.1 | 0.4 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.1 | 1.7 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 0.9 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 1.3 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 0.4 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567) |
| 0.1 | 1.8 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 0.7 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.1 | 1.3 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 1.0 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 0.9 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 0.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 3.6 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 1.8 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.6 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.6 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.4 | GO:1904949 | ATPase complex(GO:1904949) |
| 0.0 | 2.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.4 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.6 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.6 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 3.6 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.0 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 1.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.2 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 0.3 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.0 | GO:1990462 | omegasome(GO:1990462) |
| 0.0 | 0.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 6.9 | GO:0009986 | cell surface(GO:0009986) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 14.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.5 | 6.5 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.5 | 2.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.5 | 3.0 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.5 | 2.5 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.5 | 3.7 | GO:0051718 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718) |
| 0.5 | 1.4 | GO:0004471 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) |
| 0.4 | 1.8 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.4 | 4.9 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.4 | 2.0 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.4 | 1.9 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.4 | 2.3 | GO:0002135 | CTP binding(GO:0002135) |
| 0.3 | 0.9 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 0.3 | 3.7 | GO:0005522 | profilin binding(GO:0005522) |
| 0.3 | 1.1 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.3 | 1.7 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.3 | 1.1 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.3 | 1.3 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.3 | 6.7 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.2 | 0.7 | GO:0003979 | UDP-glucose 6-dehydrogenase activity(GO:0003979) |
| 0.2 | 1.7 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.2 | 0.9 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.2 | 4.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 1.7 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.2 | 1.6 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.2 | 1.6 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.2 | 1.7 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.2 | 0.8 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.2 | 0.5 | GO:0004155 | 6,7-dihydropteridine reductase activity(GO:0004155) |
| 0.2 | 3.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 3.1 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 2.4 | GO:0010181 | FMN binding(GO:0010181) |
| 0.1 | 0.7 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.1 | 1.7 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.1 | 0.7 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 0.8 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 0.4 | GO:0017116 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) |
| 0.1 | 0.3 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
| 0.1 | 0.4 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.1 | 1.3 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 1.8 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 1.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 1.0 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 1.3 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.0 | 3.7 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 1.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 1.0 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 1.4 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.0 | 0.7 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 0.8 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 0.6 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 2.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.9 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.2 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.0 | 1.0 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.2 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.0 | 1.7 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 0.2 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 1.3 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 3.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.2 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.1 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
