Motif ID: Nfe2l2

Z-value: 0.716


Transcription factors associated with Nfe2l2:

Gene SymbolEntrez IDGene Name
Nfe2l2 ENSMUSG00000015839.6 Nfe2l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfe2l2mm10_v2_chr2_-_75704535_757046410.441.1e-02Click!


Activity profile for motif Nfe2l2.

activity profile for motif Nfe2l2


Sorted Z-values histogram for motif Nfe2l2

Sorted Z-values for motif Nfe2l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_126799163 7.266 ENSMUST00000032934.5
 Aldoa
aldolase A, fructose-bisphosphate
chr7_-_126799134 6.962 ENSMUST00000087566.4
 Aldoa
aldolase A, fructose-bisphosphate
chrX_+_164269371 4.948 ENSMUST00000145412.1
ENSMUST00000033749.7
 Pir

pirin

chr5_+_128601106 4.525 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chrX_-_52613913 3.805 ENSMUST00000069360.7
 Gpc3
glypican 3
chr2_+_153649442 3.740 ENSMUST00000072997.3
ENSMUST00000109773.1
ENSMUST00000109774.2
ENSMUST00000081628.6
ENSMUST00000103151.1
ENSMUST00000088976.5
ENSMUST00000109772.1
ENSMUST00000103150.3
ENSMUST00000056495.7
 Dnmt3b








DNA methyltransferase 3B








chr17_+_86963279 3.729 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chrX_-_52613936 3.632 ENSMUST00000114857.1
 Gpc3
glypican 3
chr4_+_116685859 3.451 ENSMUST00000129315.1
ENSMUST00000106470.1
 Prdx1

peroxiredoxin 1

chr4_+_116685544 3.086 ENSMUST00000135573.1
ENSMUST00000151129.1
 Prdx1

peroxiredoxin 1

chr18_+_61639542 3.075 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr3_+_131110350 3.049 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr8_+_106510853 2.859 ENSMUST00000080797.6
 Cdh3
cadherin 3
chr10_+_17796256 2.758 ENSMUST00000037964.6
 Txlnb
taxilin beta
chr12_+_80518990 2.706 ENSMUST00000021558.6
 Galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr1_+_165769392 2.372 ENSMUST00000040298.4
 Creg1
cellular repressor of E1A-stimulated genes 1
chr18_-_53418004 2.129 ENSMUST00000025419.7
 Ppic
peptidylprolyl isomerase C
chr17_-_47834682 2.088 ENSMUST00000066368.6
 Mdfi
MyoD family inhibitor
chr1_-_167285110 2.047 ENSMUST00000027839.8
 Uck2
uridine-cytidine kinase 2
chr7_-_44997221 1.905 ENSMUST00000152341.1
 Bcl2l12
BCL2-like 12 (proline rich)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 14.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 8.5 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
2.5 7.4 GO:0072180 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
0.2 4.9 GO:0030224 monocyte differentiation(GO:0030224)
0.6 4.5 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
1.2 3.7 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.4 3.7 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.2 3.7 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
1.0 3.0 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.7 2.9 GO:0048819 positive regulation of keratinocyte proliferation(GO:0010838) regulation of hair follicle maturation(GO:0048819) regulation of catagen(GO:0051794)
0.8 2.3 GO:0097278 complement-dependent cytotoxicity(GO:0097278)
0.1 2.2 GO:0043248 proteasome assembly(GO:0043248)
0.1 2.1 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 2.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.7 2.0 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.6 1.9 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 1.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.8 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 1.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.6 1.7 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 14.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 7.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 6.9 GO:0009986 cell surface(GO:0009986)
0.3 6.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 5.0 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 3.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 3.6 GO:0005884 actin filament(GO:0005884)
0.3 3.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 3.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 3.0 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 2.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 2.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.8 GO:0032420 stereocilium(GO:0032420)
0.6 1.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 1.7 GO:0016460 myosin II complex(GO:0016460)
0.3 1.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 1.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 1.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 14.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 6.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.5 6.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.4 4.9 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 4.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.5 3.7 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.3 3.7 GO:0005522 profilin binding(GO:0005522)
0.0 3.7 GO:0002039 p53 binding(GO:0002039)
0.2 3.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 3.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 3.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 3.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 2.8 GO:0019905 syntaxin binding(GO:0019905)
0.5 2.5 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 2.4 GO:0010181 FMN binding(GO:0010181)
0.4 2.3 GO:0002135 CTP binding(GO:0002135)
0.5 2.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.4 2.0 GO:0004849 uridine kinase activity(GO:0004849)
0.4 1.9 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.4 1.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)