Motif ID: Nfia

Z-value: 2.638


Transcription factors associated with Nfia:

Gene SymbolEntrez IDGene Name
Nfia ENSMUSG00000028565.12 Nfia

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfiamm10_v2_chr4_+_97777606_977776320.639.0e-05Click!


Activity profile for motif Nfia.

activity profile for motif Nfia


Sorted Z-values histogram for motif Nfia

Sorted Z-values for motif Nfia



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfia

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78324200 24.063 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr6_+_141524379 23.976 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr7_+_130936172 20.955 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr18_+_20665250 19.399 ENSMUST00000075312.3
 Ttr
transthyretin
chr11_-_102897146 19.298 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr11_-_102897123 18.992 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr7_-_97417730 16.674 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr6_-_115251839 15.169 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr4_-_64046925 14.810 ENSMUST00000107377.3
 Tnc
tenascin C
chr19_+_5740885 12.631 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr19_-_5457397 12.524 ENSMUST00000179549.1
 Ccdc85b
coiled-coil domain containing 85B
chr5_-_104114088 12.442 ENSMUST00000031249.3
 Sparcl1
SPARC-like 1
chr16_+_91269759 11.871 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chrX_+_166344692 11.573 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr19_-_42202150 10.447 ENSMUST00000018966.7
 Sfrp5
secreted frizzled-related sequence protein 5
chr8_+_57455898 10.100 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr5_+_66968416 10.100 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr15_+_40655020 9.837 ENSMUST00000053467.4
 Zfpm2
zinc finger protein, multitype 2
chr6_+_90465287 9.599 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chr2_-_25469742 9.464 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 347 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.4 38.3 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
2.4 24.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
4.3 21.4 GO:0070327 thyroid hormone transport(GO:0070327)
3.5 21.0 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
2.0 20.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 18.8 GO:0031032 actomyosin structure organization(GO:0031032)
3.7 18.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.6 17.5 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
3.2 15.9 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
4.9 14.8 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
4.4 13.3 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
1.9 13.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.3 13.1 GO:0090527 actin filament reorganization(GO:0090527)
4.2 12.6 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.7 11.6 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.9 11.3 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
3.5 10.4 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.3 10.2 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
2.0 10.1 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
0.4 10.1 GO:0033622 integrin activation(GO:0033622)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 57.5 GO:0031012 extracellular matrix(GO:0031012)
0.1 48.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 45.9 GO:0016021 integral component of membrane(GO:0016021)
0.0 38.5 GO:0005783 endoplasmic reticulum(GO:0005783)
9.6 38.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 23.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 21.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 21.2 GO:0031225 anchored component of membrane(GO:0031225)
1.1 17.8 GO:0005614 interstitial matrix(GO:0005614)
0.2 16.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 15.1 GO:0000786 nucleosome(GO:0000786)
0.1 14.6 GO:0005884 actin filament(GO:0005884)
0.1 13.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 13.2 GO:0005581 collagen trimer(GO:0005581)
0.1 12.9 GO:0005901 caveola(GO:0005901)
1.6 11.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.5 11.2 GO:0031430 M band(GO:0031430)
0.0 10.2 GO:0030424 axon(GO:0030424)
2.5 10.1 GO:0044306 neuron projection terminus(GO:0044306)
0.1 10.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 47.2 GO:0005178 integrin binding(GO:0005178)
4.0 24.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
6.0 24.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.0 22.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
2.7 21.4 GO:0070324 thyroid hormone binding(GO:0070324)
4.6 18.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
5.3 16.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
1.2 15.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 15.6 GO:0003779 actin binding(GO:0003779)
0.3 14.9 GO:0005518 collagen binding(GO:0005518)
2.5 14.8 GO:0045545 syndecan binding(GO:0045545)
0.3 14.8 GO:0015459 potassium channel regulator activity(GO:0015459)
4.4 13.3 GO:0098809 nitrite reductase activity(GO:0098809)
1.3 13.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.6 12.5 GO:0051787 misfolded protein binding(GO:0051787)
0.5 11.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 11.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.8 10.9 GO:0030284 estrogen receptor activity(GO:0030284)
1.0 10.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
2.0 10.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)