Motif ID: Nfic_Nfib

Z-value: 2.544

Transcription factors associated with Nfic_Nfib:

Gene SymbolEntrez IDGene Name
Nfib ENSMUSG00000008575.11 Nfib
Nfic ENSMUSG00000055053.11 Nfic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nficmm10_v2_chr10_-_81427114_814271870.811.0e-08Click!
Nfibmm10_v2_chr4_-_82505274_825053580.522.0e-03Click!


Activity profile for motif Nfic_Nfib.

activity profile for motif Nfic_Nfib


Sorted Z-values histogram for motif Nfic_Nfib

Sorted Z-values for motif Nfic_Nfib



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfic_Nfib

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_43730593 31.950 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr11_+_78324200 31.454 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr6_-_115251839 27.033 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr6_+_135362931 22.977 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr8_+_72646679 22.048 ENSMUST00000161386.1
ENSMUST00000093427.4
 Nwd1

NACHT and WD repeat domain containing 1

chr2_-_25469742 21.509 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 21.506 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr8_+_72646728 19.997 ENSMUST00000161254.1
 Nwd1
NACHT and WD repeat domain containing 1
chr2_-_164404606 19.136 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
 Matn4


matrilin 4


chr11_+_3488275 18.916 ENSMUST00000064265.6
 Pla2g3
phospholipase A2, group III
chr10_+_86302854 18.165 ENSMUST00000132307.1
 Timp3
tissue inhibitor of metalloproteinase 3
chr10_+_57784859 17.394 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr1_-_162859684 15.776 ENSMUST00000131058.1
 Fmo1
flavin containing monooxygenase 1
chr6_+_17306335 15.390 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr4_+_130047840 14.321 ENSMUST00000044565.8
ENSMUST00000132251.1
 Col16a1

collagen, type XVI, alpha 1

chr16_+_90831113 14.045 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr7_-_97417730 13.842 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr3_+_94933041 13.259 ENSMUST00000090839.5
 Selenbp1
selenium binding protein 1
chr1_+_185454803 13.142 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr11_+_78322965 13.099 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.2 45.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
8.6 43.0 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
4.3 42.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
5.7 34.4 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
4.0 31.9 GO:0070314 G1 to G0 transition(GO:0070314)
1.5 27.8 GO:0060134 prepulse inhibition(GO:0060134)
3.1 22.0 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
4.1 20.7 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
0.8 20.7 GO:0033622 integrin activation(GO:0033622)
3.2 19.2 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.4 19.0 GO:0048678 response to axon injury(GO:0048678)
4.7 18.9 GO:0019372 lipoxygenase pathway(GO:0019372)
2.7 18.9 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
1.9 16.9 GO:0042940 D-amino acid transport(GO:0042940)
1.7 16.7 GO:0009404 toxin metabolic process(GO:0009404)
0.9 16.2 GO:0032060 bleb assembly(GO:0032060)
0.5 15.1 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.5 13.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.5 12.3 GO:0006910 phagocytosis, recognition(GO:0006910)
1.3 11.9 GO:0006691 leukotriene metabolic process(GO:0006691)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 73.8 GO:0016021 integral component of membrane(GO:0016021)
0.5 38.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
4.9 34.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.1 29.5 GO:0030424 axon(GO:0030424)
0.0 25.8 GO:0005615 extracellular space(GO:0005615)
0.0 24.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 24.4 GO:0030017 sarcomere(GO:0030017)
2.3 20.9 GO:0097449 astrocyte projection(GO:0097449)
1.4 20.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 20.0 GO:0005814 centriole(GO:0005814)
4.8 19.2 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 18.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 17.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 16.2 GO:0043025 neuronal cell body(GO:0043025)
0.1 11.6 GO:0005604 basement membrane(GO:0005604)
0.8 10.5 GO:0070852 cell body fiber(GO:0070852)
0.2 10.3 GO:0044297 cell body(GO:0044297)
0.1 9.6 GO:0005901 caveola(GO:0005901)
0.2 9.5 GO:0031902 late endosome membrane(GO:0031902)
0.3 9.1 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 45.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
7.4 44.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
10.8 43.0 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.4 39.9 GO:0005178 integrin binding(GO:0005178)
1.5 34.4 GO:0051787 misfolded protein binding(GO:0051787)
0.7 29.1 GO:0005504 fatty acid binding(GO:0005504)
1.4 20.8 GO:0008430 selenium binding(GO:0008430)
4.1 20.7 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
3.1 18.9 GO:0015265 urea channel activity(GO:0015265)
0.2 17.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
3.3 16.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.6 16.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.7 13.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 12.3 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.5 11.8 GO:0030506 ankyrin binding(GO:0030506)
1.3 11.7 GO:0015643 toxic substance binding(GO:0015643)
1.9 11.6 GO:0019841 retinol binding(GO:0019841)
2.2 10.8 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
3.4 10.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
2.4 9.7 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)