Motif ID: Nfil3_Tef

Z-value: 2.232

Transcription factors associated with Nfil3_Tef:

Gene SymbolEntrez IDGene Name
Nfil3 ENSMUSG00000056749.7 Nfil3
Tef ENSMUSG00000022389.8 Tef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tefmm10_v2_chr15_+_81811414_818114910.905.9e-13Click!
Nfil3mm10_v2_chr13_-_52981027_529810830.364.1e-02Click!


Activity profile for motif Nfil3_Tef.

activity profile for motif Nfil3_Tef


Sorted Z-values histogram for motif Nfil3_Tef

Sorted Z-values for motif Nfil3_Tef



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfil3_Tef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_55681257 29.265 ENSMUST00000044767.8
 Neurod6
neurogenic differentiation 6
chr1_-_91459254 22.420 ENSMUST00000069620.8
 Per2
period circadian clock 2
chr14_+_65971049 17.972 ENSMUST00000128539.1
 Clu
clusterin
chr14_+_65970804 17.174 ENSMUST00000138191.1
 Clu
clusterin
chr14_+_65971164 15.562 ENSMUST00000144619.1
 Clu
clusterin
chr14_+_65970610 14.186 ENSMUST00000127387.1
 Clu
clusterin
chr2_-_25469742 12.793 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr6_-_113934679 12.382 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr14_-_18239053 12.055 ENSMUST00000090543.5
 Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr4_-_151044564 12.047 ENSMUST00000103204.4
 Per3
period circadian clock 3
chr2_+_131909928 11.639 ENSMUST00000091288.6
 Prnp
prion protein
chr9_-_40346290 11.290 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr2_-_25470031 10.583 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr11_-_101785252 10.371 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr16_+_45093611 10.005 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr11_-_106216318 9.224 ENSMUST00000002043.3
 Ccdc47
coiled-coil domain containing 47
chr1_+_179803376 8.852 ENSMUST00000097454.2
 Gm10518
predicted gene 10518
chr2_+_131909951 8.802 ENSMUST00000124100.1
ENSMUST00000136783.1
 PRND

prion protein gene complex (Prn), transcript variant 1, mRNA

chr17_+_26715644 8.582 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr15_-_8710409 8.520 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.8 64.9 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
1.5 29.3 GO:0021542 dentate gyrus development(GO:0021542)
0.2 26.3 GO:0007623 circadian rhythm(GO:0007623)
4.7 23.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 17.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
4.2 16.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
2.3 16.4 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
2.1 12.4 GO:0048840 otolith development(GO:0048840)
0.7 12.1 GO:2000505 regulation of energy homeostasis(GO:2000505)
0.9 12.0 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
2.9 11.6 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885) cellular response to copper ion(GO:0071280)
0.4 11.3 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.9 10.5 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.9 9.2 GO:0006983 ER overload response(GO:0006983)
1.4 8.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 8.7 GO:0008333 endosome to lysosome transport(GO:0008333)
1.7 8.6 GO:1900170 prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
4.2 8.5 GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.1 8.4 GO:0006342 chromatin silencing(GO:0006342)
0.9 7.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.3 64.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.3 25.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
1.1 17.0 GO:0005614 interstitial matrix(GO:0005614)
1.0 16.8 GO:0043205 fibril(GO:0043205)
0.0 15.4 GO:0000790 nuclear chromatin(GO:0000790)
0.1 13.1 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.3 12.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.7 11.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 11.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 10.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.8 8.5 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 7.9 GO:0005730 nucleolus(GO:0005730)
1.1 7.4 GO:0070695 FHF complex(GO:0070695)
0.7 6.5 GO:0005883 neurofilament(GO:0005883)
0.0 6.2 GO:0045202 synapse(GO:0045202)
0.2 5.4 GO:0030673 axolemma(GO:0030673)
0.5 4.8 GO:0042581 specific granule(GO:0042581)
0.4 4.4 GO:0000805 X chromosome(GO:0000805)
0.2 4.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 4.3 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 64.9 GO:0051787 misfolded protein binding(GO:0051787)
0.1 26.9 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 24.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
5.8 23.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
4.4 22.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
1.0 12.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
2.0 12.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 10.9 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.6 10.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.4 10.0 GO:0001968 fibronectin binding(GO:0001968)
0.3 9.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 9.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 8.7 GO:0008565 protein transporter activity(GO:0008565)
2.7 8.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 8.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.9 6.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 6.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.8 6.3 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 6.2 GO:0018602 sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635)
0.0 6.0 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)