Motif ID: Nfkb2

Z-value: 0.591


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46304709_46304811-0.722.1e-06Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Showing 1 to 20 of 67 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_29289300 2.850 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_+_167001417 1.975 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr1_+_74791516 1.711 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr13_-_111490111 1.695 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490028 1.605 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chrX_+_163908982 1.582 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr5_+_37245792 1.462 ENSMUST00000031004.7
 Crmp1
collapsin response mediator protein 1
chr2_-_37422869 1.355 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr19_+_7268296 1.276 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr1_+_167001457 1.213 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr2_-_32312162 1.123 ENSMUST00000155269.1
 Dnm1
dynamin 1
chr10_+_80702649 1.068 ENSMUST00000095426.3
 Izumo4
IZUMO family member 4
chr14_+_80000292 1.012 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr7_+_19176416 1.010 ENSMUST00000117338.1
 Eml2
echinoderm microtubule associated protein like 2
chrX_+_163909132 0.950 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr11_-_33147400 0.923 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr5_+_110544326 0.890 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr4_-_125127817 0.890 ENSMUST00000036188.7
 Zc3h12a
zinc finger CCCH type containing 12A
chr7_+_16309577 0.864 ENSMUST00000002152.6
 Bbc3
BCL2 binding component 3
chr11_+_70029742 0.845 ENSMUST00000132597.2
 Dlg4
discs, large homolog 4 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0035690 cellular response to drug(GO:0035690)
0.1 2.5 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.4 1.5 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 1.4 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 1.4 GO:0048733 sebaceous gland development(GO:0048733)
0.2 1.2 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.1 1.1 GO:1903423 positive regulation of synaptic vesicle recycling(GO:1903423)
0.2 1.0 GO:0070942 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943)
0.1 1.0 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 1.0 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.3 0.9 GO:0045472 response to ether(GO:0045472) negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of tumor necrosis factor secretion(GO:1904468)
0.2 0.9 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.2 0.9 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.8 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.8 GO:0006903 vesicle targeting(GO:0006903)
0.2 0.7 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.5 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 0.5 GO:0060384 innervation(GO:0060384)
0.0 0.5 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.1 0.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.5 GO:0031941 filamentous actin(GO:0031941)
0.0 1.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.1 GO:0043196 varicosity(GO:0043196)
0.1 1.0 GO:0042581 specific granule(GO:0042581)
0.0 1.0 GO:0016363 nuclear matrix(GO:0016363)
0.2 0.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.8 GO:0044224 juxtaparanode region of axon(GO:0044224) cerebellar mossy fiber(GO:0044300)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 1.7 GO:0005109 frizzled binding(GO:0005109)
0.1 1.5 GO:0031005 filamin binding(GO:0031005)
0.3 1.2 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.0 1.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 1.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.0 GO:0045296 cadherin binding(GO:0045296)
0.3 0.9 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.9 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.1 0.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)