Motif ID: Nfkb2

Z-value: 0.591


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46304709_46304811-0.722.1e-06Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_29289300 2.850 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_+_167001417 1.975 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr1_+_74791516 1.711 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr13_-_111490111 1.695 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490028 1.605 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chrX_+_163908982 1.582 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr5_+_37245792 1.462 ENSMUST00000031004.7
 Crmp1
collapsin response mediator protein 1
chr2_-_37422869 1.355 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr19_+_7268296 1.276 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr1_+_167001457 1.213 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr2_-_32312162 1.123 ENSMUST00000155269.1
 Dnm1
dynamin 1
chr10_+_80702649 1.068 ENSMUST00000095426.3
 Izumo4
IZUMO family member 4
chr14_+_80000292 1.012 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr7_+_19176416 1.010 ENSMUST00000117338.1
 Eml2
echinoderm microtubule associated protein like 2
chrX_+_163909132 0.950 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr11_-_33147400 0.923 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr5_+_110544326 0.890 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr4_-_125127817 0.890 ENSMUST00000036188.7
 Zc3h12a
zinc finger CCCH type containing 12A
chr7_+_16309577 0.864 ENSMUST00000002152.6
 Bbc3
BCL2 binding component 3
chr11_+_70029742 0.845 ENSMUST00000132597.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr1_-_66817536 0.827 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr11_-_84870712 0.787 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
 Ggnbp2



gametogenetin binding protein 2



chr19_+_6341121 0.781 ENSMUST00000025897.6
ENSMUST00000130382.1
 Map4k2

mitogen-activated protein kinase kinase kinase kinase 2

chr11_-_84870646 0.732 ENSMUST00000018547.2
 Ggnbp2
gametogenetin binding protein 2
chr14_-_55591077 0.718 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
 Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chr11_-_84870812 0.694 ENSMUST00000168434.1
 Ggnbp2
gametogenetin binding protein 2
chr19_-_46338632 0.678 ENSMUST00000051234.8
ENSMUST00000167861.1
 Cuedc2

CUE domain containing 2

chr14_-_30607808 0.652 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr8_-_105289465 0.568 ENSMUST00000171788.1
ENSMUST00000014981.6
 4931428F04Rik

RIKEN cDNA 4931428F04 gene

chr14_-_30626196 0.566 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr5_+_90759299 0.542 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr11_-_54962903 0.513 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
 Tnip1




TNFAIP3 interacting protein 1




chr5_-_137531204 0.464 ENSMUST00000150063.2
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr18_-_77565050 0.455 ENSMUST00000182153.1
ENSMUST00000182146.1
ENSMUST00000026494.7
ENSMUST00000182024.1
 Rnf165



ring finger protein 165



chr11_+_101176041 0.447 ENSMUST00000103109.3
 Cntnap1
contactin associated protein-like 1
chr5_+_90891234 0.444 ENSMUST00000031327.8
 Cxcl1
chemokine (C-X-C motif) ligand 1
chr9_+_55326913 0.387 ENSMUST00000085754.3
ENSMUST00000034862.4
 AI118078

expressed sequence AI118078

chr4_+_129985098 0.339 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr7_-_34654342 0.333 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr16_-_60605226 0.326 ENSMUST00000068860.6
 Epha6
Eph receptor A6
chr19_+_45015198 0.318 ENSMUST00000179108.1
 Lzts2
leucine zipper, putative tumor suppressor 2
chr11_-_84870188 0.317 ENSMUST00000154915.2
 Ggnbp2
gametogenetin binding protein 2
chr1_+_135132693 0.280 ENSMUST00000049449.4
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr1_-_63114516 0.270 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr17_+_35866606 0.247 ENSMUST00000113814.4
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr2_-_77816758 0.216 ENSMUST00000111831.1
 Zfp385b
zinc finger protein 385B
chr1_-_63114255 0.215 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
 Ino80d



INO80 complex subunit D



chr17_+_35424842 0.204 ENSMUST00000174699.1
 H2-Q6
histocompatibility 2, Q region locus 6
chr4_+_129984833 0.198 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr5_-_137530990 0.195 ENSMUST00000132525.1
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr1_+_135133272 0.188 ENSMUST00000167080.1
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr3_-_116423930 0.168 ENSMUST00000106491.2
 Cdc14a
CDC14 cell division cycle 14A
chr17_+_34898931 0.156 ENSMUST00000097342.3
ENSMUST00000013931.5
 Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr3_-_116424007 0.154 ENSMUST00000090464.4
 Cdc14a
CDC14 cell division cycle 14A
chr11_-_70015346 0.144 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr15_-_76918010 0.142 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr10_-_89686250 0.139 ENSMUST00000092227.5
ENSMUST00000174252.1
 Scyl2

SCY1-like 2 (S. cerevisiae)

chr8_+_108714644 0.116 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr17_+_35379608 0.114 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr8_+_79028317 0.082 ENSMUST00000087927.4
ENSMUST00000098614.2
 Zfp827

zinc finger protein 827

chr14_+_55591708 0.081 ENSMUST00000019443.8
 Rnf31
ring finger protein 31
chr17_+_35979851 0.068 ENSMUST00000087200.3
 Gnl1
guanine nucleotide binding protein-like 1
chr4_-_133339238 0.064 ENSMUST00000105906.1
 Wdtc1
WD and tetratricopeptide repeats 1
chr17_+_35866056 0.064 ENSMUST00000122899.1
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr4_+_100776664 0.063 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr17_-_35980197 0.020 ENSMUST00000055454.7
 Prr3
proline-rich polypeptide 3
chr1_-_5019342 0.008 ENSMUST00000002533.8
 Rgs20
regulator of G-protein signaling 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.3 0.9 GO:0045472 response to ether(GO:0045472) negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of tumor necrosis factor secretion(GO:1904468)
0.2 1.0 GO:0070942 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943)
0.2 1.2 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.2 0.9 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.2 0.9 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2 0.7 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 1.1 GO:1903423 positive regulation of synaptic vesicle recycling(GO:1903423)
0.1 1.4 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 1.4 GO:0048733 sebaceous gland development(GO:0048733)
0.1 2.5 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.1 1.0 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.8 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 0.2 GO:0036166 phenotypic switching(GO:0036166)
0.1 0.5 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 0.3 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.0 0.8 GO:0006903 vesicle targeting(GO:0006903)
0.0 2.9 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0 1.0 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.5 GO:0060384 innervation(GO:0060384)
0.0 0.1 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.5 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.0 0.1 GO:0023035 CD40 signaling pathway(GO:0023035) protein linear polyubiquitination(GO:0097039)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.1 GO:0043196 varicosity(GO:0043196)
0.1 1.0 GO:0042581 specific granule(GO:0042581)
0.0 0.8 GO:0044224 juxtaparanode region of axon(GO:0044224) cerebellar mossy fiber(GO:0044300)
0.0 1.5 GO:0031941 filamentous actin(GO:0031941)
0.0 2.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.0 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 0.9 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 1.2 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.1 1.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 0.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 1.5 GO:0031005 filamin binding(GO:0031005)
0.1 0.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 1.0 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.9 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 1.2 GO:0008565 protein transporter activity(GO:0008565)