Motif ID: Nkx2-1
Z-value: 0.700
![logo of Nkx2-1](../logos/Nkx2-1.png)
Transcription factors associated with Nkx2-1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx2-1 | ENSMUSG00000001496.9 | Nkx2-1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx2-1 | mm10_v2_chr12_-_56536895_56536937 | 0.67 | 2.0e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.6 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
0.7 | 2.1 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
0.7 | 2.8 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
0.7 | 2.7 | GO:0002339 | B cell selection(GO:0002339) |
0.6 | 2.9 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
0.5 | 1.6 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
0.5 | 4.0 | GO:0071732 | cellular response to nitric oxide(GO:0071732) |
0.5 | 1.9 | GO:0035878 | nail development(GO:0035878) |
0.5 | 2.8 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
0.5 | 3.7 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
0.4 | 2.9 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
0.3 | 0.9 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
0.3 | 0.9 | GO:0072034 | renal vesicle induction(GO:0072034) |
0.3 | 1.8 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
0.2 | 0.6 | GO:0072718 | response to cisplatin(GO:0072718) |
0.2 | 2.0 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.2 | 0.8 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
0.2 | 0.5 | GO:0007521 | muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596) |
0.2 | 0.5 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
0.2 | 1.5 | GO:0060179 | male mating behavior(GO:0060179) |
0.1 | 2.5 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
0.1 | 1.2 | GO:0032306 | regulation of prostaglandin secretion(GO:0032306) |
0.1 | 3.6 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
0.1 | 0.4 | GO:0019042 | viral latency(GO:0019042) |
0.1 | 2.4 | GO:0032288 | myelin assembly(GO:0032288) |
0.1 | 0.8 | GO:0042940 | D-amino acid transport(GO:0042940) |
0.1 | 1.2 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
0.1 | 2.5 | GO:0006974 | cellular response to DNA damage stimulus(GO:0006974) |
0.1 | 0.4 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
0.1 | 0.6 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
0.1 | 0.5 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
0.1 | 1.7 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
0.0 | 0.6 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
0.0 | 1.4 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
0.0 | 0.2 | GO:2000065 | negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) regulation of cortisol biosynthetic process(GO:2000064) negative regulation of cortisol biosynthetic process(GO:2000065) |
0.0 | 0.9 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
0.0 | 1.7 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
0.0 | 0.5 | GO:0003334 | keratinocyte development(GO:0003334) |
0.0 | 2.2 | GO:0006959 | humoral immune response(GO:0006959) |
0.0 | 0.1 | GO:0072592 | oxygen metabolic process(GO:0072592) |
0.0 | 0.1 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
0.0 | 0.2 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
0.0 | 1.2 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
0.0 | 0.4 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
0.0 | 0.5 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
0.0 | 3.4 | GO:0006814 | sodium ion transport(GO:0006814) |
0.0 | 0.0 | GO:0030070 | insulin processing(GO:0030070) |
0.0 | 1.4 | GO:0016567 | protein ubiquitination(GO:0016567) |
0.0 | 0.3 | GO:0006999 | nuclear pore organization(GO:0006999) |
0.0 | 0.0 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
0.0 | 1.9 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
0.0 | 0.1 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.0 | 0.7 | GO:0035058 | nonmotile primary cilium assembly(GO:0035058) |
0.0 | 0.0 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 2.9 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
0.4 | 2.1 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.4 | 2.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.2 | 1.9 | GO:0030056 | hemidesmosome(GO:0030056) |
0.2 | 1.2 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.1 | 1.2 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
0.1 | 0.6 | GO:0002177 | manchette(GO:0002177) |
0.1 | 0.9 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
0.1 | 2.2 | GO:0097386 | glial cell projection(GO:0097386) |
0.1 | 1.5 | GO:0043218 | compact myelin(GO:0043218) |
0.1 | 1.1 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.1 | 1.2 | GO:0005652 | nuclear lamina(GO:0005652) |
0.1 | 0.4 | GO:0097513 | myosin II filament(GO:0097513) |
0.1 | 0.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.1 | 0.4 | GO:0031415 | NatA complex(GO:0031415) |
0.0 | 0.4 | GO:0070688 | MLL5-L complex(GO:0070688) |
0.0 | 0.7 | GO:0097539 | ciliary transition fiber(GO:0097539) |
0.0 | 0.6 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 2.9 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.8 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 1.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.0 | 1.4 | GO:0031594 | neuromuscular junction(GO:0031594) |
0.0 | 6.1 | GO:0031012 | extracellular matrix(GO:0031012) |
0.0 | 2.0 | GO:0005884 | actin filament(GO:0005884) |
0.0 | 1.8 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
0.0 | 0.0 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.6 | GO:0016880 | acid-ammonia (or amide) ligase activity(GO:0016880) |
0.6 | 2.8 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.4 | 1.6 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
0.4 | 1.9 | GO:0038132 | neuregulin binding(GO:0038132) |
0.3 | 2.7 | GO:0015643 | toxic substance binding(GO:0015643) |
0.3 | 4.0 | GO:0001223 | transcription coactivator binding(GO:0001223) |
0.2 | 1.8 | GO:0048495 | Roundabout binding(GO:0048495) |
0.2 | 2.0 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.2 | 4.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 0.9 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
0.1 | 0.8 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
0.1 | 1.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.1 | 0.9 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
0.1 | 3.4 | GO:0005272 | sodium channel activity(GO:0005272) |
0.1 | 3.1 | GO:0005109 | frizzled binding(GO:0005109) |
0.1 | 3.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 3.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
0.1 | 0.8 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
0.1 | 0.9 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
0.0 | 0.6 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
0.0 | 0.9 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.0 | 0.6 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.0 | 3.5 | GO:0008565 | protein transporter activity(GO:0008565) |
0.0 | 0.4 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
0.0 | 0.9 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
0.0 | 2.1 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
0.0 | 0.6 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.0 | 3.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.2 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
0.0 | 0.1 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.0 | 2.7 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
0.0 | 5.1 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
0.0 | 1.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 0.3 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
0.0 | 0.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.0 | 0.0 | GO:0001851 | complement component C3b binding(GO:0001851) proteinase activated receptor binding(GO:0031871) |