Motif ID: Nkx2-1

Z-value: 0.700


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.672.0e-05Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 104 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_103314944 4.289 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr3_+_52268337 4.048 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr5_+_128601106 3.677 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr2_-_170406501 3.294 ENSMUST00000154650.1
 Bcas1
breast carcinoma amplified sequence 1
chr19_+_44493472 3.069 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr15_-_88978958 2.902 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr1_+_12718496 2.791 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr17_+_34263209 2.705 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr1_+_153900572 2.584 ENSMUST00000139476.1
 Glul
glutamate-ammonia ligase (glutamine synthetase)
chr13_-_71963713 2.562 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr8_-_46294592 2.486 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr4_-_9643638 2.111 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
 Asph




aspartate-beta-hydroxylase




chr14_+_27238018 2.066 ENSMUST00000049206.5
 Arhgef3
Rho guanine nucleotide exchange factor (GEF) 3
chrX_+_100730178 1.994 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr14_-_30915387 1.933 ENSMUST00000166622.1
 Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr2_+_71786923 1.862 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr1_+_75450699 1.802 ENSMUST00000037708.9
 Asic4
acid-sensing (proton-gated) ion channel family member 4
chr4_+_45203921 1.745 ENSMUST00000107804.1
 Frmpd1
FERM and PDZ domain containing 1
chr1_-_163725123 1.677 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr2_+_10153563 1.675 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.0 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.5 3.7 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 3.6 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 3.4 GO:0006814 sodium ion transport(GO:0006814)
0.6 2.9 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.4 2.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.7 2.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.5 2.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.7 2.7 GO:0002339 B cell selection(GO:0002339)
0.9 2.6 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 2.5 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 2.5 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)
0.1 2.4 GO:0032288 myelin assembly(GO:0032288)
0.0 2.2 GO:0006959 humoral immune response(GO:0006959)
0.7 2.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 2.0 GO:0090527 actin filament reorganization(GO:0090527)
0.5 1.9 GO:0035878 nail development(GO:0035878)
0.0 1.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.3 1.8 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.7 GO:0031365 N-terminal protein amino acid modification(GO:0031365)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0031012 extracellular matrix(GO:0031012)
1.0 2.9 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 2.9 GO:0005901 caveola(GO:0005901)
0.4 2.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.2 GO:0097386 glial cell projection(GO:0097386)
0.4 2.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 2.0 GO:0005884 actin filament(GO:0005884)
0.2 1.9 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 1.5 GO:0043218 compact myelin(GO:0043218)
0.0 1.4 GO:0031594 neuromuscular junction(GO:0031594)
0.2 1.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 1.2 GO:0005652 nuclear lamina(GO:0005652)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.9 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 0.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.7 GO:0097539 ciliary transition fiber(GO:0097539)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.2 4.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 4.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.5 GO:0008565 protein transporter activity(GO:0008565)
0.1 3.4 GO:0005272 sodium channel activity(GO:0005272)
0.1 3.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 3.1 GO:0005109 frizzled binding(GO:0005109)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 2.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 2.7 GO:0015643 toxic substance binding(GO:0015643)
0.0 2.7 GO:0008276 protein methyltransferase activity(GO:0008276)
0.9 2.6 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 2.1 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.2 2.0 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.4 1.9 GO:0038132 neuregulin binding(GO:0038132)
0.0 1.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.8 GO:0048495 Roundabout binding(GO:0048495)
0.4 1.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)