Motif ID: Nkx2-2

Z-value: 1.309


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_147186413-0.096.2e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3018753 6.925 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr14_-_19418930 6.641 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3034599 6.174 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3025417 5.764 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3005125 5.395 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3015654 5.391 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 5.251 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chrX_+_9885622 3.738 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr10_+_88091070 3.525 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr19_-_5796924 2.793 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr3_+_118433797 2.465 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr3_+_5218516 2.215 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr10_-_33995054 1.731 ENSMUST00000164429.1
 Gm17567
predicted gene, 17567
chr2_-_140170528 1.713 ENSMUST00000046030.7
 Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr9_+_72438519 1.588 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr4_+_115563649 1.465 ENSMUST00000141033.1
ENSMUST00000030486.8
ENSMUST00000126645.1
ENSMUST00000030480.3
 Cyp4a31



cytochrome P450, family 4, subfamily a, polypeptide 31



chr15_-_10470490 1.446 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr16_-_16527364 1.438 ENSMUST00000069284.7
 Fgd4
FYVE, RhoGEF and PH domain containing 4
chr9_+_72438534 1.358 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr10_+_93897156 1.342 ENSMUST00000180815.1
 4930471D02Rik
RIKEN cDNA 4930471D02 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.2 3.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 2.9 GO:0070986 left/right axis specification(GO:0070986)
0.7 2.8 GO:0035063 nuclear speck organization(GO:0035063)
0.1 2.2 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.7 2.1 GO:0051542 elastin biosynthetic process(GO:0051542)
0.0 1.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 1.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.2 1.4 GO:0030035 microspike assembly(GO:0030035)
0.1 1.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 1.4 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 1.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 1.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 1.2 GO:0007601 visual perception(GO:0007601)
0.4 1.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.2 1.1 GO:0030242 pexophagy(GO:0030242)
0.3 1.0 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 1.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.3 0.8 GO:0046078 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0005882 intermediate filament(GO:0005882)
0.0 2.6 GO:0070382 exocytic vesicle(GO:0070382)
0.0 2.5 GO:0016607 nuclear speck(GO:0016607)
0.0 2.2 GO:0072562 blood microparticle(GO:0072562)
0.1 2.0 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 1.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.4 GO:0030175 filopodium(GO:0030175)
0.3 1.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.2 GO:0005922 connexon complex(GO:0005922)
0.0 1.2 GO:0031985 Golgi cisterna(GO:0031985)
0.0 1.1 GO:0005902 microvillus(GO:0005902)
0.2 1.0 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 1.0 GO:0001940 male pronucleus(GO:0001940)
0.1 0.8 GO:0070578 RISC-loading complex(GO:0070578)
0.1 0.8 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 3.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.2 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.7 2.1 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 1.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 1.5 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.2 1.5 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 1.4 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.1 GO:0001848 complement binding(GO:0001848)
0.0 1.1 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 1.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.9 GO:0019894 kinesin binding(GO:0019894)
0.3 0.8 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.8 GO:0005542 folic acid binding(GO:0005542)
0.1 0.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.5 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.1 0.4 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)